公开(公告)号：US20130226258A1

公开(公告)日：2013-08-29

申请号：US13861947

申请日：2013-04-12

申请人： Cardiac Pacemakers, Inc.

发明人： Barun Maskara ,  Lili Liu ,  Guy Alvarez ,  Scott A. Meyer

IPC分类号： A61N1/365

CPC分类号： A61N1/36564

摘要： A system and method for detecting and treating symptoms of early decompensation utilizing a cardiac rhythm management. The system applies an electrical stimulus to the patient's heart at a first set of pacing parameters including a lower rate limit (LRL) setting, and acquires a coronary venous pressure (CVP) signal from a pressure sensor implanted in a coronary vein of the patient. An average coronary venous end diastolic pressure (CV-EDP) value is calculated from the CVP signal. The system monitors the average CV-EDP value over a predetermined interval, and dynamically adjusts the LRL setting responsive to the detection of a first or a second predetermined event based on the average CV-EDP value.

摘要翻译： 一种利用心律管理检测和治疗早期失代偿症状的系统和方法。 该系统以包括较低速率限制（LRL）设置在内的第一组起搏参数对患者的心脏施加电刺激，并从植入患者冠状静脉的压力传感器获取冠状静脉压（CVP）信号。 根据CVP信号计算平均冠状静脉舒张末期压（CV-EDP）值。 该系统在预定间隔内监视平均CV-EDP值，并且响应于基于平均CV-EDP值的第一或第二预定事件的检测动态地调整LRL设置。

公开(公告)号：US20130338727A1

公开(公告)日：2013-12-19

申请号：US13894348

申请日：2013-05-14

申请人： Cardiac Pacemakers, Inc.

发明人： Eric A. Mokelke ,  Shibaji Shome ,  Guy Alvarez ,  Harlan Bos ,  Kenneth Martin Stein ,  John D. Hatlestad

IPC分类号： A61N1/36

CPC分类号： A61N1/3606 ,  A61B5/1116 ,  A61B5/1118 ,  A61B5/4836 ,  A61B5/686 ,  A61B2560/0209 ,  A61N1/36117 ,  A61N1/36139 ,  A61N1/3615 ,  A61N1/36167

摘要： Some embodiments, by way of example, provide a system, comprising a posture change detector configured to detect a posture transition indicative of an increased risk of syncope, and a neural stimulator configured to deliver a neural stimulation therapy. The neural stimulator may include a syncope avoidance module configured to respond to a detected posture transition by temporarily overriding the neural stimulation therapy to ameliorate the risk of increased syncope.

摘要翻译： 作为示例，一些实施例提供了一种系统，其包括姿态变化检测器，其被配置为检测指示晕厥风险增加的姿势转换，以及被配置为递送神经刺激治疗的神经刺激器。 神经刺激器可以包括晕厥避免模块，其被配置为通过暂时超越神经刺激疗法来应答检测到的姿势转变，以改善晕厥增加的风险。

公开(公告)号：US20130310889A1

公开(公告)日：2013-11-21

申请号：US13952933

申请日：2013-07-29

申请人： Cardiac Pacemakers, Inc.

发明人： Allan C. Shuros ,  Shantha Arcot-Krishnamurthy ,  Guy Alvarez

IPC分类号： A61N1/365

CPC分类号： A61N1/36564 ,  A61N1/3621 ,  A61N1/365

摘要： Described are methods and devices for improving diastolic function with electrostimulation in heart failure patients who exhibit relatively normal systolic function. Such patients are characterized by impaired myocardial relaxation during diastole that prevents adequate filling of the ventricles during diastole to thereby reduce cardiac output. An implantable device is described for effecting strategic and periodic stimulation of the sympathetic nervous system to elicit myocardial adrenergic activation for improved myocardial relaxation.

摘要翻译： 描述了用于在呈现相对正常的收缩功能的心力衰竭患者中用电刺激改善舒张功能的方法和装置。 这些患者的特征在于舒张期期间的心肌松弛受损，其在舒张期期间阻止充足的心室充盈，从而降低心输出量。 描述了可植入装置，用于促进交感神经系统的战略和周期性刺激，以引发心肌肾上腺素能活化以改善心肌松弛。

公开(公告)号：US08583232B2

公开(公告)日：2013-11-12

申请号：US13858270

申请日：2013-04-08

申请人： Cardiac Pacemakers, Inc.

发明人： Barun Maskara ,  Lili Liu ,  Guy Alvarez ,  Scott A. Meyer

IPC分类号： A61N1/08

CPC分类号： A61N1/36564 ,  A61N1/36542 ,  A61N1/36585

摘要： A system and method for pacing rate control in a cardiac rhythm management (CRM) system. The method includes acquiring a pressure signal representative of coronary venous pressure (CVP) from a pressure sensor implanted within a coronary vein of the patient and generating a CVP waveform from the pressure signal. A pacing stimulus is applied to the patient's heart, and the pacing rate is increased in response to increases in patient's metabolic demand. The CVP index is monitored during the pacing rate increase, and the CRM system detects a reduction in the patient's hemodymanic performance based on the CVP index and establishes a maximum rate setting based on the pacing rate corresponding to the reduction in the patient's hemodynamic performance.

摘要翻译： 用于心律管理（CRM）系统中起搏速率控制的系统和方法。 该方法包括从植入患者冠状静脉内的压力传感器获取代表冠状静脉压（CVP）的压力信号，并从压力信号产生CVP波形。 对患者的心脏施加起搏刺激，并且响应于患者代谢需求的增加而起搏速率增加。 在起搏速率增加期间监测CVP指数，并且CRM系统基于CVP指数检测患者血液动力学性能的降低，并且基于与患者血液动力学性能的降低相对应的起搏速率来建立最大速率设定。

公开(公告)号：US09403007B2

公开(公告)日：2016-08-02

申请号：US13894348

申请日：2013-05-14

申请人： Cardiac Pacemakers, Inc.

发明人： Eric A. Mokelke ,  Shibaji Shome ,  Guy Alvarez ,  Harlan Bos ,  Kenneth Martin Stein ,  John D. Hatlestad

IPC分类号： A61N1/36 ,  A61B5/11 ,  A61B5/00

CPC分类号： A61N1/3606 ,  A61B5/1116 ,  A61B5/1118 ,  A61B5/4836 ,  A61B5/686 ,  A61B2560/0209 ,  A61N1/36117 ,  A61N1/36139 ,  A61N1/3615 ,  A61N1/36167

摘要： Some embodiments, by way of example, provide a system, comprising a posture change detector configured to detect a posture transition indicative of an increased risk of syncope, and a neural stimulator configured to deliver a neural stimulation therapy. The neural stimulator may include a syncope avoidance module configured to respond to a detected posture transition by temporarily overriding the neural stimulation therapy to ameliorate the risk of increased syncope.

摘要翻译： 作为示例，一些实施例提供了一种系统，其包括姿态变化检测器，其被配置为检测指示晕厥风险增加的姿势转换，以及被配置为递送神经刺激治疗的神经刺激器。 神经刺激器可以包括晕厥避免模块，其被配置为通过暂时超越神经刺激疗法来应答检测到的姿势转变，以改善晕厥增加的风险。

公开(公告)号：US09278217B2

公开(公告)日：2016-03-08

申请号：US13952933

申请日：2013-07-29

申请人： Cardiac Pacemakers, Inc.

发明人： Allan C. Shuros ,  Shantha Arcot-Krishnamurthy ,  Guy Alvarez

IPC分类号： A61N1/365 ,  A61N1/362

CPC分类号： A61N1/36564 ,  A61N1/3621 ,  A61N1/365

摘要： Described are methods and devices for improving diastolic function with electrostimulation in heart failure patients who exhibit relatively normal systolic function. Such patients are characterized by impaired myocardial relaxation during diastole that prevents adequate filling of the ventricles during diastole to thereby reduce cardiac output. An implantable device is described for effecting strategic and periodic stimulation of the sympathetic nervous system to elicit myocardial adrenergic activation for improved myocardial relaxation.

公开(公告)号：US08825156B2

公开(公告)日：2014-09-02

申请号：US13861947

申请日：2013-04-12

申请人： Cardiac Pacemakers, Inc.

发明人： Barun Maskara ,  Lili Liu ,  Guy Alvarez ,  Scott A. Meyer

IPC分类号： A61N1/08 ,  A61N1/365

CPC分类号： A61N1/36564

摘要： A system and method for detecting and treating symptoms of early decompensation utilizing a cardiac rhythm management. The system applies an electrical stimulus to the patient's heart at a first set of pacing parameters including a lower rate limit (LRL) setting, and acquires a coronary venous pressure (CVP) signal from a pressure sensor implanted in a coronary vein of the patient. An average coronary venous end diastolic pressure (CV-EDP) value is calculated from the CVP signal. The system monitors the average CV-EDP value over a predetermined interval, and dynamically adjusts the LRL setting responsive to the detection of a first or a second predetermined event based on the average CV-EDP value.

摘要翻译： 一种利用心律管理检测和治疗早期失代偿症状的系统和方法。 该系统以包括较低速率限制（LRL）设置在内的第一组起搏参数对患者的心脏施加电刺激，并从植入患者冠状静脉的压力传感器获取冠状静脉压（CVP）信号。 根据CVP信号计算平均冠状静脉舒张末期压（CV-EDP）值。 该系统在预定间隔内监视平均CV-EDP值，并且响应于基于平均CV-EDP值的第一或第二预定事件的检测动态地调整LRL设置。

公开(公告)号：US20130226257A1

公开(公告)日：2013-08-29

申请号：US13858270

申请日：2013-04-08

申请人： Cardiac Pacemakers, Inc.

发明人： Barun Maskara ,  Lili Liu ,  Guy Alvarez ,  Scott A. Meyer

IPC分类号： A61N1/365

CPC分类号： A61N1/36564 ,  A61N1/36542 ,  A61N1/36585

摘要： A system and method for pacing rate control in a cardiac rhythm management (CRM) system. The method includes acquiring a pressure signal representative of coronary venous pressure (CVP) from a pressure sensor implanted within a coronary vein of the patient and generating a CVP waveform from the pressure signal. A pacing stimulus is applied to the patient's heart, and the pacing rate is increased in response to increases in patient's metabolic demand. The CVP index is monitored during the pacing rate increase, and the CRM system detects a reduction in the patient's hemodymanic performance based on the CVP index and establishes a maximum rate setting based on the pacing rate corresponding to the reduction in the patient's hemodynamic performance.

摘要翻译： 用于心律管理（CRM）系统中起搏速率控制的系统和方法。 该方法包括从植入患者冠状静脉内的压力传感器获取代表冠状静脉压（CVP）的压力信号，并从压力信号产生CVP波形。 对患者的心脏施加起搏刺激，并且响应于患者代谢需求的增加而起搏速率增加。 在起搏速率增加期间监测CVP指数，并且CRM系统基于CVP指数检测患者血液动力学性能的降低，并且基于与患者血液动力学性能的降低相对应的起搏速率来建立最大速率设定。