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    Systems and methods to optimize pacing fusion with native activation
    3.
    发明授权
    Systems and methods to optimize pacing fusion with native activation 有权
    用本地激活优化起搏融合的系统和方法

    公开(公告)号：US09089710B2

    公开(公告)日：2015-07-28

    申请号：US14086515

    申请日：2013-11-21

    Applicant: Cardiac Pacemakers, Inc.

    Inventor： Barun Maskara ,  Allan C. Shuros

    IPC: A61N1/00 ,  A61N1/368 ,  A61N1/362 ,  A61N1/365

    CPC classification number: A61N1/3682 ,  A61N1/3627 ,  A61N1/36564 ,  A61N1/3684

    Abstract: In an example, a pacing therapy can be optimized using information indicative of an offset duration between an intrinsic first atrioventricular delay of a subject at rest and a second atrioventricular delay specified to enhance a cardiac output of the subject heart when the subject is at rest. Optimizing the therapy can include receiving information about a heart rate of the subject and receiving information about an intrinsic, heart rate dependent atrioventricular delay. In an example, a therapy parameter, such as a therapy atrioventricular delay, can be adjusted using information about the received heart rate of the subject, the heart-rate-dependent third AV delay, or the offset duration.

    Abstract translation: 在一个示例中，可以使用指示休息的受试者的固有的第一房室延迟与被指定的第二房室延迟之间的偏移持续时间的信息来优化起搏治疗，以在受试者静止时增强主体心脏的心输出量。 优化治疗可以包括接收关于受试者的心率的信息并且接收关于固有的心率依赖性房室延迟的信息。 在一个示例中，可以使用关于受试者的接收心率，心率依赖的第三AV延迟或偏移持续时间的信息来调整诸如治疗房室延迟的治疗参数。

    Stimulation patch with passive adhesion
    4.
    发明授权
    Stimulation patch with passive adhesion 有权
    刺激贴片被动粘连

    公开(公告)号：US08965512B2

    公开(公告)日：2015-02-24

    申请号：US14104786

    申请日：2013-12-12

    Applicant: Cardiac Pacemakers, Inc.

    Inventor： Allan C. Shuros ,  Ismail Guler ,  Richard Charles Gunderson ,  Joel P. Grover ,  Eric A. Mokelke ,  Adam David Grovender

    IPC: A61N1/00 ,  A61N1/36

    CPC classification number: A61N1/36117 ,  A61N1/0558

    Abstract: System and methods for adhering a patch of stimulation electrode(s) to blood vessels to stimulate a target site on the blood vessel are described. In various embodiments, the system includes an adhesion patch and at least one electrode. The adhesion patch includes a passive adhesion mechanism that may produce an adhesive force sufficiently strong to adhere the adhesion patch to the exterior of the blood vessel and to operationally position the at least one electrode for use in electrically stimulating a target site of the blood vessel. The adhesion patch may also include a release mechanism that is configured for a user to disengage the patch from the exterior of the blood vessel without significant trauma to the blood vessel. After being released, the adhesion patch may be re-adhered to a different target site of the blood vessel and stimulate the different target site.

    Abstract translation: 描述了将一束刺激电极粘附到血管上以刺激血管上的靶位点的系统和方法。 在各种实施例中，系统包括粘附贴片和至少一个电极。 粘合贴片包括被动粘附机构，其可以产生足够强的粘附力，以将粘附贴片粘附到血管外部，并且可操作地定位所述至少一个电极以用于电刺激血管的靶位点。 粘合贴片还可以包括释放机构，该释放机构构造成使用户能够将血块从血管的外部脱离，而不会对血管造成显着的创伤。 释放后，粘附贴片可以再粘附到血管的不同靶位点并刺激不同的靶位点。

    Method and apparatus for right ventricular resynchronization
    5.
    发明授权
    Method and apparatus for right ventricular resynchronization 有权
    用于右心室再同步的方法和装置

    公开(公告)号：US08942805B2

    公开(公告)日：2015-01-27

    申请号：US14104281

    申请日：2013-12-12

    Applicant: Cardiac Pacemakers, Inc.

    Inventor： Allan C. Shuros ,  Jiang Ding ,  Barun Maskara ,  Yinghong Yu

    IPC: A61N1/00 ,  A61N1/365 ,  A61N1/05 ,  A61N1/368

    CPC classification number: A61N1/36585 ,  A61N1/056 ,  A61N1/365 ,  A61N1/36514 ,  A61N1/3682 ,  A61N1/3684

    Abstract: An apparatus comprises a cardiac signal sensing circuit and a first implantable electrode pair. At least one electrode of the first implantable electrode pair is configured for placement at a location in a right branch of a His bundle of the subject. The apparatus can include a therapy circuit and a control circuit. The control circuit can include an AH delay calculation circuit configured to calculate an optimal paced AH delay interval. The pacing stimulation location is distal to a location of RV conduction block in a right branch of the His bundle. The control circuit initiates delivery of an electrical stimulation pulse to the stimulation location in the His bundle according to the calculated paced AH delay interval and in response to an intrinsic depolarization event sensed in an atrium of the subject.

    Abstract translation: 一种装置包括心脏信号感测电路和第一可植入电极对。 第一可植入电极对的至少一个电极被配置用于放置在受试者的His束的右分支中的位置处。 该装置可以包括治疗电路和控制电路。 控制电路可以包括AH延迟计算电路，配置为计算最佳起搏AH延迟间隔。 起搏刺激位置在His束的右侧分支中位于RV传导阻滞位置的远端。 控制电路根据所计算的起搏AH延迟间隔和响应于在受试者的心房中检测到的内在去极化事件，开始将电刺激脉冲传送到His束中的刺激位置。

    STIMULATION PATCH WITH ACTIVE ADHESION
    6.
    发明申请
    STIMULATION PATCH WITH ACTIVE ADHESION 有权
    具有活性粘合的刺激贴

    公开(公告)号：US20140180357A1

    公开(公告)日：2014-06-26

    申请号：US14104853

    申请日：2013-12-12

    Applicant: Cardiac Pacemakers, Inc.

    Inventor： Allan C. Shuros ,  Ismail Guler ,  Richard Charles Gunderson ,  Joel P. Grover ,  Eric A. Mokelke ,  Adam Grovender

    IPC: A61N1/36

    CPC classification number: A61N1/36117 ,  A61N1/0558

    Abstract: System and methods for adhering a patch of stimulation electrode(s) to blood vessels to stimulate a target site on the blood vessel are described. In one embodiment, the system includes an adhesion patch and at least one electrode. The adhesion patch includes an active adhesion mechanism that may produce an adhesive force sufficiently strong to adhere the adhesion patch to the exterior of the blood vessel and to operationally position the at least one electrode for use in electrically stimulating a target site of the blood vessel. The adhesion patch may also include a release mechanism that is configured for a user to disengage the patch from the exterior of the blood vessel without significant trauma to the blood vessel. After being released, the adhesion patch may be re-adhered to a different target site of the blood vessel and stimulate the different target site.

    Abstract translation: 描述了将一束刺激电极粘附到血管上以刺激血管上的靶位点的系统和方法。 在一个实施例中，系统包括粘附贴片和至少一个电极。 粘合贴片包括主动粘合机构，其可以产生足够强的粘附力，以将粘附贴片粘附到血管外部，并且可操作地定位用于电刺激血管的靶位点的至少一个电极。 粘合贴片还可以包括释放机构，该释放机构构造成使用户能够将血块从血管的外部脱离，而不会对血管造成显着的创伤。 释放后，粘附贴片可以再粘附到血管的不同靶位点并刺激不同的靶位点。

    SYSTEMS, DEVICES AND METHODS FOR MODULATING AUTONOMIC TONE
    8.
    发明申请
    SYSTEMS, DEVICES AND METHODS FOR MODULATING AUTONOMIC TONE 审中-公开
    用于调制自动音调的系统，设备和方法

    公开(公告)号：US20140121718A1

    公开(公告)日：2014-05-01

    申请号：US14147787

    申请日：2014-01-06

    Applicant: Cardiac Pacemakers, Inc.

    Inventor： Allan C. Shuros ,  Shantha Arcot-Krishnamurthy ,  Bruce H. KenKnight ,  Douglas R. Daum

    IPC: A61N1/362

    CPC classification number: A61N1/362 ,  A61N1/36114 ,  A61N1/3627

    Abstract: Various embodiments intermittently deliver a sympathetic stimulus, including deliver a sequence of stress-inducing pacing pulses adapted to increase sympathetic tone during the stress-inducing pacing. The stress-inducing pacing results in a parasympathetic reflex after the sequence of stress-inducing pacing. The embodiment further delivers neural stimulation to elicit a parasympathetic response or a sympathetic response in a coordinated manner with respect to the sequence of stress-inducing pacing pulses. The neural stimulation is timed to elicit the parasympathetic response after the sequence of stress-inducing pacing pulses and concurrent with at least a portion of the parasympathetic reflex to the sequence of stress-inducing pacing to enhance a parasympathetic effect of the parasympathetic reflex, or to elicit the sympathetic response during the sequence of stress-inducing pulses to provide a larger sympathetic stimulus, resulting in an enhanced parasympathetic reflex in response to the large sympathetic stimulus.

    Abstract translation: 各种实施方案间歇地递送交感刺激，包括递送适于在应力诱导起搏期间增加交感神经张力的应力诱发起搏脉冲序列。 应激诱导起搏导致应激诱导起搏顺序后的副交感神经反射。 该实施方案进一步递送神经刺激以相对于应力诱导起搏脉冲的序列以协调的方式引发副交感神经反应或交感神经反应。 神经刺激被定时以在应力诱发起搏脉冲序列之后引起副交感神经反应，并且与应激诱导起搏序列的至少一部分副交感神经反射并发，以增强副交感神经反射的副交感作用，或 在应激诱导脉冲序列期间引起交感神经反应以提供更大的交感神经刺激，导致响应于大的交感神经刺激的增强的副交感神经反射。

    METHOD AND APPARATUS FOR SELECTIVE HIS BUNDLE PACING
    9.
    发明申请
    METHOD AND APPARATUS FOR SELECTIVE HIS BUNDLE PACING 有权
    选择其选择的方法和装置

    公开(公告)号：US20140107724A1

    公开(公告)日：2014-04-17

    申请号：US14043523

    申请日：2013-10-01

    Applicant: Cardiac Pacemakers, Inc.

    Inventor： Allan C. Shuros ,  Jiang Ding ,  Barun Maskara ,  Rodney W. Salo

    IPC: A61N1/37

    CPC classification number: A61N1/3712 ,  A61B5/0538 ,  A61N1/371

    Abstract: A cardiac rhythm management system provides for cardiac pacing that is delivered to a target portion of conductive tissue in a heart, such as the His bundle. In various embodiments, the system is configured to verify capture of the target portion and provide for selective pacing of the target portion. In various embodiments, the system is configured to detect responses of the target portion and adjacent myocardial tissue to delivery of pacing pulses and use an outcome of the detection to verify selective capture of the target portion (i.e., without directly exciting the adjacent myocardial tissue.

    Abstract translation: 心律管理系统提供心脏起搏，其被输送到心脏中的导电组织的目标部分，例如His束。 在各种实施例中，系统被配置为验证目标部分的捕获并提供目标部分的选择性起搏。 在各种实施例中，系统被配置为检测目标部分和相邻心肌组织对递送起搏脉冲的响应，并使用检测结果来验证目标部分的选择性捕获（即，不直接激励相邻的心肌组织）。

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