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公开(公告)号：US20070191268A1
公开(公告)日：2007-08-16
申请号：US10567764
申请日：2004-08-13
IPC分类号： A61K38/17 , C07K14/47 , A61K31/728 , C07H21/04
CPC分类号： A61K38/1709 , A61K38/00 , A61K38/18 , A61K38/19 , A61K45/06 , C07K14/47 , C07K14/475 , C07K16/18
摘要： Recombinant lubricin molecules and uses thereof Novel recombinant lubricin molecules and their uses as lubricants anti-adhesive agents and/or intra-articular supplements for, e.g., synvial joints, meniscus, tendon, peritoneum, pericardium and pleura are provided.
摘要翻译： 重组润滑剂分子及其用途提供新的重组润滑剂分子及其用作润滑剂抗粘合剂和/或用于例如合成关节，半月板，腱，腹膜，心包和胸膜的关节内补充剂。
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公开(公告)号：US20050260733A1
公开(公告)日：2005-11-24
申请号：US11106623
申请日：2005-04-15
申请人： Edward LaVallie , Lisa Collins-Racie , Christopher Corcoran , Michael Agostino , Bethany Freeman , Maya Arai , Carl Flannery , Macy Jin
发明人： Edward LaVallie , Lisa Collins-Racie , Christopher Corcoran , Michael Agostino , Bethany Freeman , Maya Arai , Carl Flannery , Macy Jin
CPC分类号： A61K38/4886 , C12N9/6489 , C12Q1/37 , G01N2333/96486 , G01N2400/00 , G01N2500/00
摘要： The present invention features methods of using ADAMTS-8 proteins or their functional derivatives to cleave aggrecan or other proteoglycan molecules. The present invention also features methods for identifying ADAMTS-8 modulators that are capable of inhibiting or enhancing ADAMTS-8 proteolytic activities. In addition, the present invention features pharmaceutical compositions comprising ADAMTS-8 proteins or their derivatives or modulators. These pharmaceutical compositions can be used to treat diseases that are characterized by deficiencies or abnormalities in proteoglycan cleavage or metabolism.
摘要翻译： 本发明的特征在于使用ADAMTS-8蛋白或其功能衍生物切割聚蛋白聚糖蛋白聚糖或其他蛋白聚糖分子的方法。 本发明还涉及用于鉴定能够抑制或增强ADAMTS-8蛋白水解活性的ADAMTS-8调节剂的方法。 此外，本发明的特征在于包含ADAMTS-8蛋白质或其衍生物或调节剂的药物组合物。 这些药物组合物可用于治疗以蛋白多糖切割或代谢为特征的缺陷或异常的疾病。
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公开(公告)号：US20070128616A1
公开(公告)日：2007-06-07
申请号：US11438609
申请日：2006-05-22
申请人： Christopher Corcoran , Michael Agostino , Edward LaVallie , Carl Flannery , Weilan Zeng , Lisa Collins-Racie , Bethany Freeman
发明人： Christopher Corcoran , Michael Agostino , Edward LaVallie , Carl Flannery , Weilan Zeng , Lisa Collins-Racie , Bethany Freeman
CPC分类号： C12N9/6421 , A61K2039/505
摘要： Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods of identifying and developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
摘要翻译： 公开了新型聚蛋白聚糖蛋白聚糖蛋白和编码它们的核苷酸序列以及其制备方法。 还公开了鉴定和发展聚蛋白聚糖蛋白酶的抑制剂和用于治疗由聚集蛋白聚糖蛋白降解特征的病症的酶的抗体的方法。
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公开(公告)号：US20060228354A1
公开(公告)日：2006-10-12
申请号：US11451006
申请日：2006-06-12
申请人： Christopher Corcoran , Carl Flannery , Weilan Zeng , Lisa Racie , Thomas McDonagh , Bethany Freeman , Katy Georgiadis , Edward LaVallie
发明人： Christopher Corcoran , Carl Flannery , Weilan Zeng , Lisa Racie , Thomas McDonagh , Bethany Freeman , Katy Georgiadis , Edward LaVallie
IPC分类号： A61K39/395 , G01N33/53 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C12N9/6489 , A61K2039/505
摘要： The present invention relates to modified ADAMTS4 proteins having improved stability comparing to the corresponding native, unmodified proteins. The modified ADAMTS4 proteins can be expressed and isolated in large quantities, thus allowing further characterization of the proteins, such as crystallographic and enzyme kinetic studies. The purified, stable proteins would also facilitate the production of anti-ADAMTS antibodies and the development of inhibitors to ADAMTS enzymes.
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