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公开(公告)号：US20060228354A1
公开(公告)日：2006-10-12
申请号：US11451006
申请日：2006-06-12
申请人： Christopher Corcoran , Carl Flannery , Weilan Zeng , Lisa Racie , Thomas McDonagh , Bethany Freeman , Katy Georgiadis , Edward LaVallie
发明人： Christopher Corcoran , Carl Flannery , Weilan Zeng , Lisa Racie , Thomas McDonagh , Bethany Freeman , Katy Georgiadis , Edward LaVallie
IPC分类号： A61K39/395 , G01N33/53 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C12N9/6489 , A61K2039/505
摘要： The present invention relates to modified ADAMTS4 proteins having improved stability comparing to the corresponding native, unmodified proteins. The modified ADAMTS4 proteins can be expressed and isolated in large quantities, thus allowing further characterization of the proteins, such as crystallographic and enzyme kinetic studies. The purified, stable proteins would also facilitate the production of anti-ADAMTS antibodies and the development of inhibitors to ADAMTS enzymes.
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公开(公告)号：US20070178574A1
公开(公告)日：2007-08-02
申请号：US11467135
申请日：2006-08-24
申请人： Lydia Mosyak , Thomas Rush , Xiaotian Zhong , Thomas McDonagh , Katy Georgiadis , Phaik-Eng Sum , Edward LaVallie , Lisa Collins-Racie , Christopher Corcoran , Ravindra Kumar , Tracy Hebert , Stephane Olland , Stewart Mackie
发明人： Lydia Mosyak , Thomas Rush , Xiaotian Zhong , Thomas McDonagh , Katy Georgiadis , Phaik-Eng Sum , Edward LaVallie , Lisa Collins-Racie , Christopher Corcoran , Ravindra Kumar , Tracy Hebert , Stephane Olland , Stewart Mackie
CPC分类号： C12N9/6421 , C07K2299/00 , C07K2319/00
摘要： This invention relates to aggrecanase polypeptides and aggrecanase polypeptide/ligand complexes, crystals of aggrecanase and aggrecanase polypeptide/ligand complexes, and related methods and software systems.
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公开(公告)号：US07118902B2
公开(公告)日：2006-10-10
申请号：US10628432
申请日：2003-07-29
申请人： Christopher John Corcoran , Carl R. Flannery , Weilan Zeng , Lisa A. Racie , Thomas McDonagh , Bethany A. Freeman , Katy E. Georgiadis , Edward R. LaVallie
发明人： Christopher John Corcoran , Carl R. Flannery , Weilan Zeng , Lisa A. Racie , Thomas McDonagh , Bethany A. Freeman , Katy E. Georgiadis , Edward R. LaVallie
CPC分类号： C12N9/6489 , A61K2039/505
摘要： The present invention relates to modified ADAMTS4 proteins having improved stability comparing to the corresponding native, unmodified proteins. The modified ADAMTS4 proteins can be expressed and isolated in large quantities, thus allowing further characterization of the proteins, such as crystallographic and enzyme kinetic studies. The purified, stable proteins would also facilitate the production of anti-ADAMTS antibodies and the development of inhibitors to ADAMTS enzymes.
摘要翻译： 本发明涉及与相应的天然未修饰蛋白相比具有改进的稳定性的修饰的ADAMTS4蛋白。 修饰的ADAMTS4蛋白可以大量表达和分离，从而进一步表征蛋白质，如晶体学和酶动力学研究。 纯化的稳定蛋白质也有助于抗ADAMTS抗体的产生和ADAMTS酶抑制剂的开发。
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公开(公告)号：US20060292652A1
公开(公告)日：2006-12-28
申请号：US11181453
申请日：2005-07-13
申请人： Rory Curtis , Andrew Napper , Jeffrey Hixon , Thomas McDonagh
发明人： Rory Curtis , Andrew Napper , Jeffrey Hixon , Thomas McDonagh
摘要： Methods and compositions for evaluating nicotinamide-releasing activities as well as cell and organism-based evaluation methods are provided herein.
摘要翻译： 本文提供了用于评估烟酰胺释放活性的方法和组合物以及基于细胞和生物体的评估方法。
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公开(公告)号：US08486990B2
公开(公告)日：2013-07-16
申请号：US12423751
申请日：2009-04-14
申请人： Andrew Napper , Peter DiStefano , Rory A. Curtis , Jeffrey Hixon , Thomas McDonagh , L. Julie Huber , Jonathan M. Solomon , Russell J. Thomas , Jean-Francois Pons
发明人： Andrew Napper , Peter DiStefano , Rory A. Curtis , Jeffrey Hixon , Thomas McDonagh , L. Julie Huber , Jonathan M. Solomon , Russell J. Thomas , Jean-Francois Pons
IPC分类号： A61K31/403 , C07D209/56
CPC分类号： A61K31/403 , A61K31/404 , A61K31/437 , A61K31/4439 , A61K31/497 , A61K31/5377 , C07D209/18 , C07D209/88 , C07D209/94 , C07D471/04
摘要： Compound of formula (I) and methods of treating disorders by administering a compound of formula (I) are described herein. Examples of disorders include neoplastic disorders, fat-cell related disorders, neurodegenerative disorders, and metabolic disorders.
摘要翻译： 本文描述式（I）化合物和通过施用式（I）化合物治疗病症的方法。 病症的实例包括肿瘤性疾病，脂肪细胞相关疾病，神经变性疾病和代谢紊乱。
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公开(公告)号：US07460961B2
公开(公告)日：2008-12-02
申请号：US10894834
申请日：2004-07-20
申请人： Desiree H. H. Tsao , Jean-Baptiste Telliez , Thomas McDonagh , Lih-Ling Lin , Sang Hsu , Guang-Yi Xu , A. Karl Malakian
发明人： Desiree H. H. Tsao , Jean-Baptiste Telliez , Thomas McDonagh , Lih-Ling Lin , Sang Hsu , Guang-Yi Xu , A. Karl Malakian
CPC分类号： G06F19/16 , C07K14/7151 , C07K2299/00 , G01N33/6803 , G01N33/6863 , G01N2500/04
摘要： The present invention relates to the three dimensional solution structure of the N-terminal domain of TNFR-1 associated death domain protein (“N-TRADD”), as well as the identification and characterization of a C-TRAF2 binding active site of N-TRADD. Also provided for by the present invention are methods of utilizing the three dimensional structures for the design and selection of potent and selective inhibitors of TNF signaling pathways.
摘要翻译： 本发明涉及TNFR-1相关死亡域蛋白（“N-TRADD”）的N-末端结构域的三维溶液结构，以及N-末端结构域的N-末端结构域的鉴定和表征， TRADD。 本发明还提供了利用三维结构设计和选择有效和选择性的TNF信号通路抑制剂的方法。
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公开(公告)号：US20050209300A1
公开(公告)日：2005-09-22
申请号：US10940269
申请日：2004-09-13
申请人： Andrew Napper , Peter Distefano , Rory Curtis , Jeffrey Hixon , Thomas McDonagh , L. Huber , Jonathan Solomon , Russell Thomas , Jean-Francois Pons
发明人： Andrew Napper , Peter Distefano , Rory Curtis , Jeffrey Hixon , Thomas McDonagh , L. Huber , Jonathan Solomon , Russell Thomas , Jean-Francois Pons
IPC分类号： A61K31/35 , A61K31/38 , A61K31/40 , A61K31/403 , A61K31/445 , C07D20060101
CPC分类号： A61K31/445 , A61K31/35 , A61K31/38 , A61K31/40 , A61K31/403 , C07D209/88
摘要： Compound of formula (I) and methods of treating disorders by administering a compound of formula (I) are described herein. Examples of disorders include neoplastic disorders, fat-cell related disorders, neurodegenerative disorders, and metabolic disorders.
摘要翻译： 本文描述式（I）化合物和通过施用式（I）化合物治疗病症的方法。 病症的实例包括肿瘤性疾病，脂肪细胞相关疾病，神经变性疾病和代谢紊乱。
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公开(公告)号：US20050002898A1
公开(公告)日：2005-01-06
申请号：US10894834
申请日：2004-07-20
申请人： Desiree Tsao , Jean-Baptiste Telliez , Thomas McDonagh , Lih-Ling Lin , Sang Hsu , Guang-Yi Xu , A. Malakian
发明人： Desiree Tsao , Jean-Baptiste Telliez , Thomas McDonagh , Lih-Ling Lin , Sang Hsu , Guang-Yi Xu , A. Malakian
IPC分类号： C07K14/715 , G01N33/68 , G06F19/16 , A61K38/19 , C07K14/52
CPC分类号： G06F19/16 , C07K14/7151 , C07K2299/00 , G01N33/6803 , G01N33/6863 , G01N2500/04
摘要： The present invention relates to the three dimensional solution structure of the N-terminal domain of TNFR-1 associated death domain protein (“N-TRADD”), as well as the identification and characterization of a C-TRAF2 binding active site of N-TRADD. Also provided for by the present invention are methods of utilizing the three dimensional structures for the design and selection of potent and selective inhibitors of TNF signaling pathways.
摘要翻译： 本发明涉及TNFR-1相关死亡域蛋白（“N-TRADD”）的N-末端结构域的三维溶液结构，以及N-末端结构域的N-末端结构域的鉴定和表征， TRADD。 本发明还提供了利用三维结构设计和选择有效和选择性的TNF信号通路抑制剂的方法。
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公开(公告)号：US20090306168A1
公开(公告)日：2009-12-10
申请号：US12423751
申请日：2009-04-14
申请人： Andrew Napper , Peter DiStefano , Rory A. Curtis , Jeffrey Hixon , Thomas McDonagh , L. Julie Huber , Jonathan M. Solomon , Russell J. Thomas , Jean-Francois Pons
发明人： Andrew Napper , Peter DiStefano , Rory A. Curtis , Jeffrey Hixon , Thomas McDonagh , L. Julie Huber , Jonathan M. Solomon , Russell J. Thomas , Jean-Francois Pons
IPC分类号： A61K31/403 , A61P25/28
CPC分类号： A61K31/403 , A61K31/404 , A61K31/437 , A61K31/4439 , A61K31/497 , A61K31/5377 , C07D209/18 , C07D209/88 , C07D209/94 , C07D471/04
摘要： Compound of formula (I) and methods of treating disorders by administering a compound of formula (I) are described herein. Examples of disorders include neoplastic disorders, fat-cell related disorders, neurodegenerative disorders, and metabolic disorders.
摘要翻译： 本文描述式（I）化合物和通过施用式（I）化合物治疗病症的方法。 病症的实例包括肿瘤性疾病，脂肪细胞相关疾病，神经变性疾病和代谢紊乱。
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公开(公告)号：US20060074124A1
公开(公告)日：2006-04-06
申请号：US11077664
申请日：2005-03-11
申请人： Andrew Napper , Peter Distefano , Rory Curtis , Jeffrey Hixon , Thomas McDonagh , L. Huber , Jonathan Solomon , Russell Thomas , Jean-Francois Pons
发明人： Andrew Napper , Peter Distefano , Rory Curtis , Jeffrey Hixon , Thomas McDonagh , L. Huber , Jonathan Solomon , Russell Thomas , Jean-Francois Pons
IPC分类号： A61K31/403 , C07D209/82
CPC分类号： A61K31/403 , A61K31/404 , A61K31/437 , A61K31/4439 , A61K31/497 , A61K31/5377 , C07D209/18 , C07D209/88 , C07D209/94 , C07D471/04
摘要： Compound of formula (I) and methods of treating disorders by administering a compound of formula (I) are described herein. Examples of disorders include neoplastic disorders, fat-cell related disorders, neurodegenerative disorders, and metabolic disorders.
摘要翻译： 本文描述式（I）化合物和通过施用式（I）化合物治疗病症的方法。 病症的实例包括肿瘤性疾病，脂肪细胞相关疾病，神经变性疾病和代谢紊乱。
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