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公开(公告)号：US07521441B2
公开(公告)日：2009-04-21
申请号：US11745090
申请日：2007-05-07
申请人： Robert G. Gentles , Piyasena Hewawasam , Min Ding , Carl P. Bergstrom , Scott W. Martin , Kap-Sun Yeung , Thomas W. Hudyma , Xiaofan Zheng , John A. Bender , John F. Kadow
发明人： Robert G. Gentles , Piyasena Hewawasam , Min Ding , Carl P. Bergstrom , Scott W. Martin , Kap-Sun Yeung , Thomas W. Hudyma , Xiaofan Zheng , John A. Bender , John F. Kadow
IPC分类号： A61P31/00 , A61K31/407 , C07D487/00
CPC分类号： C07D487/04
摘要： The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
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公开(公告)号：US07473688B2
公开(公告)日：2009-01-06
申请号：US11516435
申请日：2006-09-06
申请人： Carl P. Bergstrom , John A. Bender , Robert G. Gentles , Piyasena Hewawasam , Thomas W. Hudyma , John F. Kadow , Scott W. Martin , Alicia Regueiro-Ren , Kap-Sun Yeung , Yong Tu , Katharine A. Grant-Young , Xiaofan Zheng
发明人： Carl P. Bergstrom , John A. Bender , Robert G. Gentles , Piyasena Hewawasam , Thomas W. Hudyma , John F. Kadow , Scott W. Martin , Alicia Regueiro-Ren , Kap-Sun Yeung , Yong Tu , Katharine A. Grant-Young , Xiaofan Zheng
IPC分类号： A61K31/55 , A61P31/00 , C07D223/14
CPC分类号： C07D491/14 , C07D487/04
摘要： The invention encompasses compounds and salts of Formulas I, II, III, and IV as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
摘要翻译： 本发明包括式I，II，III和IV的化合物和盐以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。
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公开(公告)号：US07456165B2
公开(公告)日：2008-11-25
申请号：US11671753
申请日：2007-02-06
IPC分类号： A61K31/55 , A61P31/00 , C07D223/14
CPC分类号： C07D487/04
摘要： The invention encompasses compounds of Formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
摘要翻译： 本发明包括式I化合物以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。
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公开(公告)号：US20070270406A1
公开(公告)日：2007-11-22
申请号：US11745090
申请日：2007-05-07
申请人： Robert G. Gentles , Piyasena Hewawasam , Min Ding , Carl P. Bergstrom , Scott W. Martin , Kap-Sun Yeung , Thomas W. Hudyma , Xiaofan Zheng , John A. Bender , John F. Kadow
发明人： Robert G. Gentles , Piyasena Hewawasam , Min Ding , Carl P. Bergstrom , Scott W. Martin , Kap-Sun Yeung , Thomas W. Hudyma , Xiaofan Zheng , John A. Bender , John F. Kadow
IPC分类号： A61K31/55 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
摘要翻译： 本发明包括式I化合物以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。
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公开(公告)号：US20070185083A1
公开(公告)日：2007-08-09
申请号：US11671753
申请日：2007-02-06
IPC分类号： A61K31/55 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention encompasses compounds of Formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
摘要翻译： 本发明包括式I化合物以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。
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公开(公告)号：US07153848B2
公开(公告)日：2006-12-26
申请号：US11181639
申请日：2005-07-14
申请人： Thomas W. Hudyma , Xiaofan Zheng , Feng He , Min Ding , Carl P. Bergstrom , Piyasena Hewawasam , Scott W. Martin , Robert G. Gentles
发明人： Thomas W. Hudyma , Xiaofan Zheng , Feng He , Min Ding , Carl P. Bergstrom , Piyasena Hewawasam , Scott W. Martin , Robert G. Gentles
IPC分类号： A61K31/55 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/4439 , A61K31/425 , A61K31/427 , A61K31/4178 , A61K31/4184 , A61K31/4025 , A61K31/403 , C07D233/32 , C07D413/14 , C07D409/14
CPC分类号： C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/14 , C07D513/14
摘要： Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions comprising the compounds are also described as well as methods of preparing the compounds.
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公开(公告)号：US07348425B2
公开(公告)日：2008-03-25
申请号：US11347765
申请日：2006-02-03
申请人： Thomas W. Hudyma , Xiaofan Zheng , Feng He , Min Ding , Carl P. Bergstrom , Piyasena Hewawasam , Scott W. Martin , Robert G. Gentles
发明人： Thomas W. Hudyma , Xiaofan Zheng , Feng He , Min Ding , Carl P. Bergstrom , Piyasena Hewawasam , Scott W. Martin , Robert G. Gentles
IPC分类号： A61K31/55 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/4439 , A61K31/425 , A61K31/427 , A61K31/403 , C07D233/32 , C07D413/14 , C07D409/14
CPC分类号： C07D471/04 , A61K31/13 , A61K31/4745 , A61K31/7056 , A61K38/13 , A61K38/2013 , A61K38/204 , A61K38/208 , A61K38/21 , A61K45/06 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/14 , C07D498/14 , C07D513/14 , A61K2300/00
摘要： Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions comprising the compounds are also described as well as methods of preparing the compounds
摘要翻译： 描述式I的吲哚化合物。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。 还描述了包含化合物的不同形式和组合物以及制备化合物的方法
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公开(公告)号：US07399758B2
公开(公告)日：2008-07-15
申请号：US11507731
申请日：2006-08-22
申请人： Nicholas A. Meanwell , Robert G. Gentles , Min Ding , John A. Bender , John F. Kadow , Piyasena Hewawasam , Thomas W. Hudyma , Xiaofan Zheng
发明人： Nicholas A. Meanwell , Robert G. Gentles , Min Ding , John A. Bender , John F. Kadow , Piyasena Hewawasam , Thomas W. Hudyma , Xiaofan Zheng
IPC分类号： A61P31/00 , A61K31/55 , C07D223/14
CPC分类号： C07D487/04
摘要： The invention encompasses compounds of Formula I, pharmaceutically acceptable salts thereof, compositions, and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
摘要翻译： 本发明包括式I的化合物，其药学上可接受的盐，组合物和使用该化合物的方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。
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公开(公告)号：US06486159B2
公开(公告)日：2002-11-26
申请号：US09789986
申请日：2001-02-21
申请人： Thomas W. Hudyma , Oak K. Kim , Xiaofan Zheng
发明人： Thomas W. Hudyma , Oak K. Kim , Xiaofan Zheng
IPC分类号： A61K314178
CPC分类号： C07D417/06 , C07D417/14
摘要： Water-soluble prodrugs of triazole antifungal compounds having a secondary or tertiary hydroxy group are provided. More particularly, new water-soluble triazole antifungal compounds are provided having the general formula wherein A is the non-hydroxy portion of a triazole antifungal compound of the type containing a secondary or tertiary hydroxyl group and n, R1 and R2 are as defined in the specification.
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公开(公告)号：US5668284A
公开(公告)日：1997-09-16
申请号：US644751
申请日：1996-05-08
申请人： Choung U. Kim , Peter F. Misco, Jr. , John A. Wichtowski , Yasutsugu Ueda , Thomas W. Hudyma , John D. Matiskella , Stanley V. D'Andrea , Shelley E. Hoeft , Raymond F. Miller , Muzammil M. Mansuri , Joanne J. Bronson
发明人： Choung U. Kim , Peter F. Misco, Jr. , John A. Wichtowski , Yasutsugu Ueda , Thomas W. Hudyma , John D. Matiskella , Stanley V. D'Andrea , Shelley E. Hoeft , Raymond F. Miller , Muzammil M. Mansuri , Joanne J. Bronson
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D501/00 , C07D501/36 , C07D211/84 , C07F9/58
CPC分类号： C07D501/00
摘要： Novel cephem derivatives represented by the general formula ##STR1## in which the Acyl substituent is a group of the formula ##STR2## wherein Ar is a lipophilic optionally substituted phenyl, naphthyl, pyridyl or benzthiazolyl group; R.sup.1 is selected from certain optionally substituted aliphatic, aromatic, arylaliphatic or sugar moieties and R.sup.2 and R.sup.3 are each independently hydrogen, alkyl or aminoalkylcarbonylamino are gram-positive antibacterial agents, especially useful in the treatment of infectious diseases caused by methicillin-resistant Staphylococcus aureus (MRSA).
摘要翻译： 由通式
表示的新型头孢烯衍生物，其中酰基取代基是式IMA的组，其中Ar是亲脂性任选取代的苯基，萘基，吡啶基或苯并噻唑基; R1选自某些任选取代的脂族，芳族，芳基脂族或糖部分，R2和R3各自独立地为氢，烷基或氨基烷基羰基氨基是革兰氏阳性抗菌剂，特别可用于治疗由耐甲氧西林金黄色葡萄球菌引起的感染性疾病（ MRSA）。
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