公开(公告)号：US06486159B2

公开(公告)日：2002-11-26

申请号：US09789986

申请日：2001-02-21

申请人： Thomas W. Hudyma ,  Oak K. Kim ,  Xiaofan Zheng

发明人： Thomas W. Hudyma ,  Oak K. Kim ,  Xiaofan Zheng

IPC分类号： A61K314178

CPC分类号： C07D417/06 ,  C07D417/14

摘要： Water-soluble prodrugs of triazole antifungal compounds having a secondary or tertiary hydroxy group are provided. More particularly, new water-soluble triazole antifungal compounds are provided having the general formula wherein A is the non-hydroxy portion of a triazole antifungal compound of the type containing a secondary or tertiary hydroxyl group and n, R1 and R2 are as defined in the specification.

公开(公告)号：US06359141B2

公开(公告)日：2002-03-19

申请号：US09789982

申请日：2001-02-21

申请人： Thomas W. Hudyma ,  Oak K. Kim ,  Xiaofan Zheng

发明人： Thomas W. Hudyma ,  Oak K. Kim ,  Xiaofan Zheng

IPC分类号： C07D27722

CPC分类号： C07D417/06 ,  C07D417/14

摘要： Water-soluble prodrugs of triazole antifungal compounds having a secondary or tertiary hydroxy group are provided. More particularly, new water-soluble triazole antifungal compounds are provided having the general formula wherein A is the non-hydroxy portion of a triazole antifungal compound of the type containing a secondary or tertiary hydroxyl group and n, R1 and R2 are as defined in the specification.

摘要翻译： 提供具有仲羟基或叔羟基的三唑抗真菌化合物的水溶性前药。 更具体地，提供了具有通式化合物的新的水溶性三唑抗真菌化合物A是包含仲羟基或叔羟基的三唑抗真菌化合物的非羟基部分，n，R 1和R 2如本说明书中所定义 。

公开(公告)号：US06620934B2

公开(公告)日：2003-09-16

申请号：US09965755

申请日：2001-09-28

申请人： Thomas W. Hudyma ,  Oak K. Kim ,  Xiaofan Zheng

发明人： Thomas W. Hudyma ,  Oak K. Kim ,  Xiaofan Zheng

IPC分类号： C07D40314

CPC分类号： C07F9/6518

摘要： Water-soluble prodrugs of triazole antifungal compounds having a secondary or tertiary hydroxy group are provided. More particularly, new water-soluble triazole antifungal compounds are provided having the general formula wherein A is the non-hydroxy portion of a triazole antifungal compound of the type containing a secondary or tertiary hydroxyl group and n, m, p, R1, R2, R3, and R4 are as defined in the specification.

公开(公告)号：US06620799B2

公开(公告)日：2003-09-16

申请号：US09966556

申请日：2001-09-27

申请人： Thomas W. Hudyma ,  Oak K. Kim ,  Xiaofan Zheng

发明人： Thomas W. Hudyma ,  Oak K. Kim ,  Xiaofan Zheng

IPC分类号： A61K31675

CPC分类号： C07F9/6518

摘要： Water-soluble prodrugs of triazole antifungal compounds having a secondary or tertiary hydroxy group are provided. More particularly, new water-soluble triazole antifungal compounds are provided having the general formula wherein A is the non-hydroxy portion of a triazole antifungal compound of the type containing a secondary or tertiary hydroxyl group and n, m, p, R1, R2, R3, and R4 are as defined in the specification.

公开(公告)号：US06458961B1

公开(公告)日：2002-10-01

申请号：US09966220

申请日：2001-09-28

申请人： Thomas W. Hudyma ,  Oak K. Kim ,  Xiaofan Zheng

发明人： Thomas W. Hudyma ,  Oak K. Kim ,  Xiaofan Zheng

IPC分类号： C07D41712

CPC分类号： C07F9/6518

摘要： Water-soluble prodrugs of triazole antifungal compounds having a secondary or tertiary hydroxy group are provided. More particularly, new water-soluble triazole antifungal compounds are provided having the general formula wherein A is the non-hydroxy portion of a triazole antifungal compound of the type containing a secondary or tertiary hydroxyl group and n, m, p, R1, R2, R3, and R4 are as defined in the specification.

摘要翻译： 提供了具有仲羟基或叔羟基的三唑抗真菌化合物的水溶性前药。 更具体地，提供了新的水溶性三唑抗真菌化合物，其具有通式化合物A是包含仲羟基或叔羟基的三唑类抗真菌化合物的非羟基部分，n，m，p，R1，R2，R3 和R4如说明书中所定义。

公开(公告)号：US07022667B2

公开(公告)日：2006-04-04

申请号：US10189710

申请日：2002-07-03

申请人： Thomas W. Hudyma ,  Xiaofan Zheng ,  B. Narasimhulu Naidu ,  Margaret E. Sorenson ,  Alicia Regueiro-Ren ,  Timothy P. Connolly ,  John D. Matiskella ,  Oak K. Kim ,  Yunhui Zhang ,  Dane M. Springer ,  Jason Goodrich ,  Yasutsugu Ueda ,  Joanne J. Bronson

发明人： Thomas W. Hudyma ,  Xiaofan Zheng ,  B. Narasimhulu Naidu ,  Margaret E. Sorenson ,  Alicia Regueiro-Ren ,  Timothy P. Connolly ,  John D. Matiskella ,  Oak K. Kim ,  Yunhui Zhang ,  Dane M. Springer ,  Jason Goodrich ,  Yasutsugu Ueda ,  Joanne J. Bronson

IPC分类号： A61K38/16

CPC分类号： C07H17/08 ,  C07D513/22 ,  C07H15/26 ,  C07H17/02 ,  C07H17/04

摘要： The present invention provides compounds of formula I having potent antibiotic activity, including activity towards Gram-positive bacteria and mycobacteria.

摘要翻译： 本发明提供具有有效抗生素活性的式I化合物，包括对革兰氏阳性菌和分枝杆菌的活性。

公开(公告)号：US06265584B1

公开(公告)日：2001-07-24

申请号：US09315606

申请日：1999-05-20

申请人： Thomas W. Hudyma ,  Oak K. Kim ,  Xiaofan Zheng

发明人： Thomas W. Hudyma ,  Oak K. Kim ,  Xiaofan Zheng

IPC分类号： C07D25112

CPC分类号： C07D417/06 ,  C07D417/14

摘要： Water-soluble prodrugs of triazole antifungal compounds having a secondary or tertiary hydroxy group are provided. More particularly, new water-soluble triazole antifungal compounds are provided having the general formula wherein A is the non-hydroxy portion of a triazole antifungal compound of the type containing a secondary or tertiary hydroxyl group and n, R1 and R2 are as defined in the specification.

摘要翻译： 提供具有仲羟基或叔羟基的三唑抗真菌化合物的水溶性前药。 更具体地，提供了具有通式化合物的新的水溶性三唑抗真菌化合物A是包含仲羟基或叔羟基的三唑抗真菌化合物的非羟基部分，n，R 1和R 2如本说明书中所定义 。

公开(公告)号：US07399758B2

公开(公告)日：2008-07-15

申请号：US11507731

申请日：2006-08-22

申请人： Nicholas A. Meanwell ,  Robert G. Gentles ,  Min Ding ,  John A. Bender ,  John F. Kadow ,  Piyasena Hewawasam ,  Thomas W. Hudyma ,  Xiaofan Zheng

发明人： Nicholas A. Meanwell ,  Robert G. Gentles ,  Min Ding ,  John A. Bender ,  John F. Kadow ,  Piyasena Hewawasam ,  Thomas W. Hudyma ,  Xiaofan Zheng

IPC分类号： A61P31/00 ,  A61K31/55 ,  C07D223/14

CPC分类号： C07D487/04

摘要： The invention encompasses compounds of Formula I, pharmaceutically acceptable salts thereof, compositions, and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.

摘要翻译： 本发明包括式I的化合物，其药学上可接受的盐，组合物和使用该化合物的方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。

公开(公告)号：US07521441B2

公开(公告)日：2009-04-21

申请号：US11745090

申请日：2007-05-07

申请人： Robert G. Gentles ,  Piyasena Hewawasam ,  Min Ding ,  Carl P. Bergstrom ,  Scott W. Martin ,  Kap-Sun Yeung ,  Thomas W. Hudyma ,  Xiaofan Zheng ,  John A. Bender ,  John F. Kadow

发明人： Robert G. Gentles ,  Piyasena Hewawasam ,  Min Ding ,  Carl P. Bergstrom ,  Scott W. Martin ,  Kap-Sun Yeung ,  Thomas W. Hudyma ,  Xiaofan Zheng ,  John A. Bender ,  John F. Kadow

IPC分类号： A61P31/00 ,  A61K31/407 ,  C07D487/00

CPC分类号： C07D487/04

摘要： The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.

公开(公告)号：US07473688B2

公开(公告)日：2009-01-06

申请号：US11516435

申请日：2006-09-06

申请人： Carl P. Bergstrom ,  John A. Bender ,  Robert G. Gentles ,  Piyasena Hewawasam ,  Thomas W. Hudyma ,  John F. Kadow ,  Scott W. Martin ,  Alicia Regueiro-Ren ,  Kap-Sun Yeung ,  Yong Tu ,  Katharine A. Grant-Young ,  Xiaofan Zheng

发明人： Carl P. Bergstrom ,  John A. Bender ,  Robert G. Gentles ,  Piyasena Hewawasam ,  Thomas W. Hudyma ,  John F. Kadow ,  Scott W. Martin ,  Alicia Regueiro-Ren ,  Kap-Sun Yeung ,  Yong Tu ,  Katharine A. Grant-Young ,  Xiaofan Zheng

IPC分类号： A61K31/55 ,  A61P31/00 ,  C07D223/14

CPC分类号： C07D491/14 ,  C07D487/04

摘要： The invention encompasses compounds and salts of Formulas I, II, III, and IV as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.

摘要翻译： 本发明包括式I，II，III和IV的化合物和盐以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。