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公开(公告)号：US12099174B2
公开(公告)日：2024-09-24
申请号：US17498339
申请日：2021-10-11
发明人： Daniel Haase , Manuel Amthor , Markus Sticker , Sebastian Backs , Thomas Ohrt , Christian Dietrich
CPC分类号： G02B21/0052 , G02B21/06 , G02B21/367 , G06N20/00
摘要： A method for generating an overview image of a sample which is arranged in an observation volume of a microscope by means of a sample carrier is proposed, wherein the sample carrier is illuminated by a first illumination, wherein a preliminary overview image is generated using the first illumination and an overview camera of the microscope, wherein an overview image illumination is chosen on the basis of the preliminary overview image, wherein the sample carrier is illuminated by the overview illumination, and wherein the overview image is generated using the overview image illumination and the overview camera.
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公开(公告)号：US12033343B2
公开(公告)日：2024-07-09
申请号：US17689022
申请日：2022-03-08
发明人： Lars Omlor , Timo Stich , Christian Dietrich
IPC分类号： G06T7/593 , H04N13/271
CPC分类号： G06T7/593 , H04N13/271 , G06T2207/10012 , G06T2207/20212
摘要： Stereoscopy in which at least one image of a scene is recorded from a first viewing angle, and at least one image of the scene is recorded from a second viewing angle. The scene is recorded multiple times from the first viewing angle. A first combination image is obtained from the various images recorded from the first viewing angle, said combination image according to the stipulation of a comparison algorithm having smaller differences in relation to at least one image also recorded from the second viewing angle or smaller differences in relation to a second combination image obtained from the images from the second viewing angle than each individual image recorded from the first viewing angle. An image of the scene with the depth information is obtained from the first combination image and at least one image from the second viewing angle or the second combination image.
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3.发明公开公开(公告)号：US20230384575A1
公开(公告)日：2023-11-30
申请号：US18203208
申请日：2023-05-30
摘要： A distance measuring device in microscopy contains a sample stage for arranging a sample carrier in a sample plane, and at least one, preferably at least two illumination sources for providing measurement radiation, which is reflected at least proportionally at a surface of the sample carrier. The device also contains a detection optical unit for capturing an overview image and occurring reflections at the sample carrier present in the sample plane; a detector disposed downstream of the detection optical unit and serving for the spatially resolved capture of image data of the sample carrier and of occurring reflections; and an evaluation device for ascertaining at least a distance of the surface at at least one location of the sample carrier. The illumination sources emit the measurement radiation in each case at a divergent emission angle. A corresponding method can be used for ascertaining a spatial orientation of a sample carrier.
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公开(公告)号：US10955653B2
公开(公告)日：2021-03-23
申请号：US16367789
申请日：2019-03-28
发明人： Lars Stoppe , Thomas Ohrt , Christian Dietrich , Markus Sticker
摘要： Various aspects of the invention relate to techniques to facilitate autofocus techniques for a test object by means of an angle-variable illumination. Here, image datasets are captured at a multiplicity of angle-variable illumination geometries. The captured image datsets are evaluated in order to determine the Z-position.
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公开(公告)号：US20170123198A1
公开(公告)日：2017-05-04
申请号：US15337156
申请日：2016-10-28
发明人： Wolfgang Singer , Aksel Goehnermeier , Guenter Rudolph , Johannes Ruoff , Christian Dietrich , Rong Dong
CPC分类号： G02B21/28 , G01N21/0332 , G01N2021/0335 , G02B21/02 , G02B21/18 , G02B21/26 , G02B21/33 , G02B21/362
摘要： The invention relates to a device for optical examination of a specimen with a cryo-immersion objective, having a stative, to which the cryo-immersion objective is fixed, wherein the cryo-immersion objective has a plurality of optical components, in particular lenses, and wherein the cryo-immersion objective has an optical front component which is in contact during operation with a coolable immersion liquid, having a specimen carrier for a specimen to be examined, having means for providing a cooled immersion liquid between the optical front component and the specimen to be examined on or against the specimen carrier. The device is characterised in that insulating means are present for interrupting a heat transition between the stative and the optical front component. The invention also relates to a method for examining a specimen, wherein with a device according to the invention a plurality of microscopic images are recorded, wherein for each of the individual images a different offset between a main housing and a separate housing is set. Finally the invention relates to a method for transferring a device according to the invention into an operation-ready state, wherein the components, cooled in operation, of the cryo-immersion objective, in particular the optical front component, are cooled with a coolant, in particular with liquid nitrogen, wherein the immersion liquid is cooled with a coolant, in particular with liquid nitrogen, and wherein thereafter the cooled components of the cryo-immersion objective are brought into contact with the immersion liquid.
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6.发明公开公开(公告)号：US20230400678A1
公开(公告)日：2023-12-14
申请号：US18207958
申请日：2023-06-09
发明人： Christian Dietrich , Jens Hofmann , Daniel Ewert
摘要： An objective attachment for a microscope objective for transporting an immersion liquid between a target region on a front side of the microscope objective and a line, comprising at least one cannula having a spout for dispensing and/or receiving the immersion liquid and having a distal opening, to which the line for the immersion liquid can be connected, and comprising a fastening device for holding the cannula on a housing of the microscope objective and for positioning the spout relative to the target region is described. The fastening device comprises at least two arms, which are configured to at least partially laterally engage around the housing of the microscope objective and to hold on the housing in a force-fitting manner. An apparatus for feeding immersion liquid to a target region on a front region of a microscope objective and/or for removing immersion liquid from the target region also is described.
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公开(公告)号：US10345570B2
公开(公告)日：2019-07-09
申请号：US15337156
申请日：2016-10-28
发明人： Wolfgang Singer , Aksel Goehnermeier , Guenter Rudolph , Johannes Ruoff , Christian Dietrich , Rong Dong
IPC分类号： G01N21/03 , G02B21/02 , G02B21/18 , G01B21/26 , G02B21/28 , G02B21/33 , G02B21/36 , G02B21/26
摘要： The invention relates to a device for optical examination of a specimen with a cryo-immersion objective, having a stative, to which the cryo-immersion objective is fixed, wherein the cryo-immersion objective has a plurality of optical components, in particular lenses, and wherein the cryo-immersion objective has an optical front component which is in contact during operation with a coolable immersion liquid, having a specimen carrier for a specimen to be examined, having means for providing a cooled immersion liquid between the optical front component and the specimen to be examined on or against the specimen carrier. The device is characterized in that insulating means are present for interrupting a heat transition between the stative and the optical front component. The invention also relates to a method for examining a specimen, wherein with a device according to the invention a plurality of microscopic images are recorded, wherein for each of the individual images a different offset between a main housing and a separate housing is set. Finally the invention relates to a method for transferring a device according to the invention into an operation-ready state, wherein the components, cooled in operation, of the cryo-immersion objective, in particular the optical front component, are cooled with a coolant, in particular with liquid nitrogen, wherein the immersion liquid is cooled with a coolant, in particular with liquid nitrogen, and wherein thereafter the cooled components of the cryo-immersion objective are brought into contact with the immersion liquid.
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公开(公告)号：US20220292704A1
公开(公告)日：2022-09-15
申请号：US17689022
申请日：2022-03-08
发明人： Lars Omlor , Timo Stich , Christian Dietrich
IPC分类号： G06T7/593 , H04N13/271
摘要： Stereoscopy in which at least one image of a scene is recorded from a first viewing angle, and at least one image of the scene is recorded from a second viewing angle. The scene is recorded multiple times from the first viewing angle. A first combination image is obtained from the various images recorded from the first viewing angle, said combination image according to the stipulation of a comparison algorithm having smaller differences in relation to at least one image also recorded from the second viewing angle or smaller differences in relation to a second combination image obtained from the images from the second viewing angle than each individual image recorded from the first viewing angle. An image of the scene with the depth information is obtained from the first combination image and at least one image from the second viewing angle or the second combination image.
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