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    Imaging fluorometer for time resolved fluorescence
    1.
    发明授权
    Imaging fluorometer for time resolved fluorescence 失效
    成像荧光计用于时间分辨荧光

    公开(公告)号：US06806455B2

    公开(公告)日：2004-10-19

    申请号：US10240615

    申请日：2002-09-30

    申请人： Carlos Zarate ,  Paul Donders ,  Ahmad Yekta ,  Zahra Masoumi ,  Peter Ramm

    发明人： Carlos Zarate ,  Paul Donders ,  Ahmad Yekta ,  Zahra Masoumi ,  Peter Ramm

    IPC分类号： H01L2700

    CPC分类号： G01N21/6408 ,  G01N2201/0648

    摘要： The present invention relates to an apparatus and method for imaging time resolved fluorescence in biochemical and medical samples. In a primary aspect, the device includes a lens of large aperture, a flash lamp in the illumination path, a fast-acting solid state shutter or a gated detector in the emission path, a device for delivering homogenous monochromatic illumination to a plurality of wells distributed within a microwell plate, a digital camera of high quantum efficiency, and a computer under computer control, the lamp is pulsed at short intervals. The fast-acting emission shutter or gated detector operates to limit exposure of the camera to a period some microseconds after the extinction of each lamp pulse, during which only delayed fluorescence is transmitted to the camera. The invention achieves simultaneous time resolved imaging of a plurality of samples, with high sensitivity and high throughput.

    摘要翻译： 本发明涉及用于在生物化学和医学样品中成像时间分辨荧光的装置和方法。 在主要方面，该装置包括大孔径的透镜，照明路径中的闪光灯，发射路径中的快速固态快门或门控检测器，用于将均匀单色照明传送到多个孔的装置 分布在微孔板内，高量子效率的数码相机和计算机在计算机控制下，以短时间间隔脉冲。 快速发射快门或门控检测器操作以将相机的曝光限制在每个灯脉冲消失之后几微秒的时段，在此期间仅将延迟的荧光传输到相机。 本发明实现多个样品的同时时间分辨成像，具有高灵敏度和高产量。

    TIME RESOLVED FLUORESCENT IMAGING SYSTEM
    3.
    发明申请
    TIME RESOLVED FLUORESCENT IMAGING SYSTEM 失效
    时间分辨率荧光成像系统

    公开(公告)号：US20100090127A1

    公开(公告)日：2010-04-15

    申请号：US12517653

    申请日：2008-01-23

    申请人： Ahmad Yekta ,  Pavel A. Fomitchov ,  Joseph Masino

    发明人： Ahmad Yekta ,  Pavel A. Fomitchov ,  Joseph Masino

    IPC分类号： G01J1/58

    CPC分类号： G01N21/6458 ,  G01N21/6408 ,  G01N2021/6439 ,  G01N2021/6441

    摘要： This invention provides a system and method that allows for time-resolved fluorescent imaging of fluorescent samples. The user is able to receive temporally filtered pictures of the sample with a reduced amount of the scattered excitation light and the short lived background fluorescence. The system allows for adjustment of fluorescent gating time and delay time.

    摘要翻译： 本发明提供允许荧光样品的时间分辨荧光成像的系统和方法。 用户能够以减少量的散射激发光和短寿命背景荧光来接收样本的时间滤波图像。 该系统允许调节荧光门控时间和延迟时间。

    CONFOCAL FLUORESCENCE LIFETIME IMAGING SYSTEM
    4.
    发明申请
    CONFOCAL FLUORESCENCE LIFETIME IMAGING SYSTEM 审中-公开
    共焦荧光生物成像系统

    公开(公告)号：US20130087718A1

    公开(公告)日：2013-04-11

    申请号：US13704741

    申请日：2011-06-27

    申请人： Erwen Mei ,  Ahmad Yekta

    发明人： Erwen Mei ,  Ahmad Yekta

    IPC分类号： G01N21/64

    CPC分类号： G01N21/645 ,  G01N21/6408 ,  G01N21/6458 ,  G01N2021/6417 ,  G02B21/16

    摘要： A confocal fluorescence lifetime imaging (FLIM) system comprising a pulsed tuneable excitation light source arranged to provide excitation radiation to an illumination area on a target, scanning means for scanning the illumination area across the target, and at least one detector for detecting fluorescent emission from the target, wherein the pulsed light source comprises a line forming unit arranged to form a line shaped illumination area of pulsed excitation light on the target, and wherein the detector comprises shutter means arranged to operate in synchronization with the pulsed light source enabling detection of time-resolved fluorescent emission intensity from the target.

    摘要翻译： 共焦荧光寿命成像（FLIM）系统，包括脉冲可调谐激发光源，其被布置成向目标上的照明区域提供激发辐射，扫描装置用于扫描靶标上的照明区域，以及至少一个检测器，用于检测荧光发射 所述目标，其中所述脉冲光源包括线形成单元，所述线形成单元布置成在所述目标上形成脉冲激发光的线形照明区域，并且其中所述检测器包括快门装置，其被布置为与所述脉冲光源同步地操作，从而能够检测时间 从目标中分辨出荧光发射强度。

    System and method for adjusting a beam expander in an imaging system
    6.
    发明授权
    System and method for adjusting a beam expander in an imaging system 失效
    用于调整成像系统中的光束扩展器的系统和方法

    公开(公告)号：US08649089B2

    公开(公告)日：2014-02-11

    申请号：US13122439

    申请日：2009-10-07

    申请人： Shaohong Wang ,  Ahmad Yekta

    发明人： Shaohong Wang ,  Ahmad Yekta

    IPC分类号： G02B21/06

    CPC分类号： G02B21/0032

    摘要： A line confocal microscope system, comprising an illumination system with a source of collimated light and a line forming optics arranged to provide a line shaped illumination area to be scanned over a sample, an image receiving system, and two or more objective lenses that are interchangeable in the optical path to provide different magnification, wherein the objective lenses have different aperture diameters, and the illumination system comprises a beam shape transformer arranged in between the source of collimated light and the line forming optics to selectively transform the cross-sectional shape of the collimated beam of light transmitted to the line forming optics to a predetermined shape in response to the back aperture diameter of the objective lens that is arranged in the optical path.

    摘要翻译： 一种线共聚焦显微镜系统，包括具有准直光源的照明系统和线形成光学器件，其布置成提供要在样品上扫描的线状照明区域，图像接收系统和可互换的两个或更多个物镜 在光路中提供不同的放大倍数，其中物镜具有不同的孔径直径，并且照明系统包括布置在准直光源和线形成光学器件之间的束形变压器，以选择性地变换 准直光束响应于设置在光路中的物镜的后孔直径传输到线形成光学到预定形状。

    Time resolved fluorescent imaging system
    10.
    发明授权
    Time resolved fluorescent imaging system 失效
    时间分辨荧光成像系统

    公开(公告)号：US08063386B2

    公开(公告)日：2011-11-22

    申请号：US12517653

    申请日：2008-01-23

    申请人： Ahmad Yekta ,  Pavel A. Fomitchov ,  Joseph Masino

    发明人： Ahmad Yekta ,  Pavel A. Fomitchov ,  Joseph Masino

    IPC分类号： G01N21/64

    CPC分类号： G01N21/6458 ,  G01N21/6408 ,  G01N2021/6439 ,  G01N2021/6441

    摘要： A system and method that allows for time-resolved fluorescent imaging of fluorescent samples. The user is able to receive temporally filtered pictures of the sample with a reduced amount of the scattered excitation light and the short lived background fluorescence. The system allows for adjustment of fluorescent gating time and delay time.

    摘要翻译： 允许荧光样品的时间分辨荧光成像的系统和方法。 用户能够以减少量的散射激发光和短寿命背景荧光来接收样本的时间滤波图像。 该系统允许调节荧光门控时间和延迟时间。