公开(公告)号：US20100090127A1

公开(公告)日：2010-04-15

申请号：US12517653

申请日：2008-01-23

申请人： Ahmad Yekta ,  Pavel A. Fomitchov ,  Joseph Masino

发明人： Ahmad Yekta ,  Pavel A. Fomitchov ,  Joseph Masino

IPC分类号： G01J1/58

CPC分类号： G01N21/6458 ,  G01N21/6408 ,  G01N2021/6439 ,  G01N2021/6441

摘要： This invention provides a system and method that allows for time-resolved fluorescent imaging of fluorescent samples. The user is able to receive temporally filtered pictures of the sample with a reduced amount of the scattered excitation light and the short lived background fluorescence. The system allows for adjustment of fluorescent gating time and delay time.

摘要翻译： 本发明提供允许荧光样品的时间分辨荧光成像的系统和方法。 用户能够以减少量的散射激发光和短寿命背景荧光来接收样本的时间滤波图像。 该系统允许调节荧光门控时间和延迟时间。

公开(公告)号：US08063386B2

公开(公告)日：2011-11-22

申请号：US12517653

申请日：2008-01-23

申请人： Ahmad Yekta ,  Pavel A. Fomitchov ,  Joseph Masino

发明人： Ahmad Yekta ,  Pavel A. Fomitchov ,  Joseph Masino

IPC分类号： G01N21/64

CPC分类号： G01N21/6458 ,  G01N21/6408 ,  G01N2021/6439 ,  G01N2021/6441

摘要： A system and method that allows for time-resolved fluorescent imaging of fluorescent samples. The user is able to receive temporally filtered pictures of the sample with a reduced amount of the scattered excitation light and the short lived background fluorescence. The system allows for adjustment of fluorescent gating time and delay time.

摘要翻译： 允许荧光样品的时间分辨荧光成像的系统和方法。 用户能够以减少量的散射激发光和短寿命背景荧光来接收样本的时间滤波图像。 该系统允许调节荧光门控时间和延迟时间。

公开(公告)号：US08053711B2

公开(公告)日：2011-11-08

申请号：US12523066

申请日：2008-01-28

申请人： Pavel A. Fomitchov ,  Kaushal Verma ,  Joseph Masino

发明人： Pavel A. Fomitchov ,  Kaushal Verma ,  Joseph Masino

IPC分类号： G02B7/04

CPC分类号： G02B27/0068

摘要： A spherical aberration adjustment system is disclosed, which includes a plurality of objective lenses, where at least one of the plurality of objective lenses has a spherical aberration collar. The plurality of objective lenses are mounted onto an objective holder, where the objective holder is configured to place the at least one of the plurality of objective lenses in an imaging position. A driving mechanism is coupled by a mechanical link to the at least one of the plurality of objective lenses, where the mechanical link is configured to transmit motion from the driving mechanism to the spherical aberration collar. A control system is configured to manipulate the driving mechanism to move the spherical aberration collar of the at least one of the plurality of objective lenses in the imaging position to a specific spherical aberration adjustment setting.

摘要翻译： 公开了一种球面像差调整系统，其包括多个物镜，其中多个物镜中的至少一个具有球面像差轴环。 多个物镜安装在物镜支架上，其中物镜支架构造成将多个物镜中的至少一个放置在成像位置。 驱动机构通过机械连杆耦合到多个物镜中的至少一个物镜，其中机械连杆构造成将运动从驱动机构传递到球面像差轴环。 控制系统被配置为操纵驱动机构以将成像位置中的多个物镜中的至少一个的球面像差轴环移动到特定的球面像差调整设置。

公开(公告)号：US20100033812A1

公开(公告)日：2010-02-11

申请号：US12523066

申请日：2008-01-28

申请人： Pavel A. Fomitchov ,  Kaushal Verma ,  Joseph Masino

发明人： Pavel A. Fomitchov ,  Kaushal Verma ,  Joseph Masino

IPC分类号： G02B7/09 ,  G02B7/14 ,  G02B21/02

CPC分类号： G02B27/0068

摘要： A spherical aberration adjustment system is disclosed, which includes a plurality of objective lenses, where at least one of the plurality of objective lenses has a spherical aberration collar. The plurality of objective lenses are mounted onto an objective holder, where the objective holder is configured to place the at least one of the plurality of objective lenses in an imaging position. A driving mechanism is coupled by a mechanical link to the at least one of the plurality of objective lenses, where the mechanical link is configured to transmit motion from the driving mechanism to the spherical aberration collar. A control system is configured to manipulate the driving mechanism to move the spherical aberration collar of the at least one of the plurality of objective lenses in the imaging position to a specific spherical aberration adjustment setting.

摘要翻译： 公开了一种球面像差调整系统，其包括多个物镜，其中多个物镜中的至少一个具有球面像差轴环。 多个物镜安装在物镜支架上，其中物镜支架构造成将多个物镜中的至少一个放置在成像位置。 驱动机构通过机械连杆耦合到多个物镜中的至少一个物镜，其中机械连杆构造成将运动从驱动机构传递到球面像差轴环。 控制系统被配置为操纵驱动机构以将成像位置中的多个物镜中的至少一个的球面像差轴环移动到特定的球面像差调整设置。

公开(公告)号：USD603965S1

公开(公告)日：2009-11-10

申请号：US29277414

申请日：2007-02-26

申请人： Kaushal Verma ,  Joseph Masino ,  Pavel A. Fomitchov ,  Liqin Wang

设计人： Kaushal Verma ,  Joseph Masino ,  Pavel A. Fomitchov ,  Liqin Wang

公开(公告)号：US20070206192A1

公开(公告)日：2007-09-06

申请号：US11363938

申请日：2006-03-01

申请人： Pavel Fomitchov ,  Eugene Barash ,  Ahmad Yekta ,  Joseph Masino

发明人： Pavel Fomitchov ,  Eugene Barash ,  Ahmad Yekta ,  Joseph Masino

IPC分类号： G01N21/25

CPC分类号： G01N21/6458 ,  G01N21/47 ,  G01N2201/0407 ,  G01N2201/1042 ,  G02B21/0048 ,  G02B21/0076 ,  G02B21/367

摘要： A system and method for multimode imaging of at least one sample is disclosed. The system includes at least one light source; an optical system selected responsive to a mode of operation of the imaging system; and a detector capable of selective reading of pixels. The at least one sample is moved elative to the optical system using a sample movement technique selected from the group consisting of step sample moving and continuous sample moving. The method includes the steps of (1) selecting a mode of operation for the imaging system; (2) transmitting light from at least one light source through an optical system selected in response to the mode of operation for the imaging system; (3) moving the at least one sample relative to the optical system using a sample movement technique selected from the group consisting of step sample moving and continuous sample moving; and (4) selectively reading pixels with a detector.

摘要翻译： 公开了一种用于至少一个样品的多模成像的系统和方法。 该系统包括至少一个光源; 响应于成像系统的操作模式选择的光学系统; 以及能够选择性地读取像素的检测器。 使用选自步骤样品移动和连续样品移动的样品移动技术将至少一个样品移动到光学系统。 该方法包括以下步骤：（1）选择成像系统的操作模式; （2）从至少一个光源透射通过响应于成像系统的操作模式选择的光学系统的光; （3）使用选自步骤样品移动和连续样品移动的样本移动技术来移动所述至少一个样品相对于所述光学系统; 和（4）用检测器选择性地读取像素。