公开(公告)号：US08649089B2

公开(公告)日：2014-02-11

申请号：US13122439

申请日：2009-10-07

申请人： Shaohong Wang ,  Ahmad Yekta

发明人： Shaohong Wang ,  Ahmad Yekta

IPC分类号： G02B21/06

CPC分类号： G02B21/0032

摘要： A line confocal microscope system, comprising an illumination system with a source of collimated light and a line forming optics arranged to provide a line shaped illumination area to be scanned over a sample, an image receiving system, and two or more objective lenses that are interchangeable in the optical path to provide different magnification, wherein the objective lenses have different aperture diameters, and the illumination system comprises a beam shape transformer arranged in between the source of collimated light and the line forming optics to selectively transform the cross-sectional shape of the collimated beam of light transmitted to the line forming optics to a predetermined shape in response to the back aperture diameter of the objective lens that is arranged in the optical path.

摘要翻译： 一种线共聚焦显微镜系统，包括具有准直光源的照明系统和线形成光学器件，其布置成提供要在样品上扫描的线状照明区域，图像接收系统和可互换的两个或更多个物镜 在光路中提供不同的放大倍数，其中物镜具有不同的孔径直径，并且照明系统包括布置在准直光源和线形成光学器件之间的束形变压器，以选择性地变换 准直光束响应于设置在光路中的物镜的后孔直径传输到线形成光学到预定形状。

公开(公告)号：US20110188105A1

公开(公告)日：2011-08-04

申请号：US13122439

申请日：2009-10-07

申请人： Shaohong Wang ,  Ahmad Yekta

发明人： Shaohong Wang ,  Ahmad Yekta

IPC分类号： G02B26/08

CPC分类号： G02B21/0032

摘要： A line confocal microscope system, comprising an illumination system with a source of collimated light and a line forming optics arranged to provide a line shaped illumination area to be scanned over a sample, an image receiving system, and two or more objective lenses that are interchangeable in the optical path to provide different magnification, wherein the objective lenses have different aperture diameters, and the illumination system comprises a beam shape transformer arranged in between the source of collimated light and the line forming optics to selectively transform the cross-sectional shape of the collimated beam of light transmitted to the line forming optics to a predetermined shape in response to the back aperture diameter of the objective lens that is arranged in the optical path.

摘要翻译： 一种线共聚焦显微镜系统，包括具有准直光源的照明系统和线形成光学器件，其布置成提供要在样品上扫描的线状照明区域，图像接收系统和可互换的两个或更多个物镜 在光路中提供不同的放大倍数，其中物镜具有不同的孔径直径，并且照明系统包括布置在准直光源和线形成光学器件之间的束形变压器，以选择性地变换 准直光束响应于设置在光路中的物镜的后孔直径传输到线形成光学到预定形状。

公开(公告)号：US20110273547A1

公开(公告)日：2011-11-10

申请号：US12776797

申请日：2010-05-10

申请人： Shaohong Wang ,  Carlos Barnes Gonzalez

发明人： Shaohong Wang ,  Carlos Barnes Gonzalez

IPC分类号： H04N7/18

CPC分类号： G01N21/6458 ,  G01N21/64 ,  G01N2201/0806

摘要： A method and an apparatus for imaging a biologic sample is provided. The apparatus includes at least one light source, at least one lens array, at least one image detector, a positioning system, and an image processor. The lens array has a plurality of lengthwise extending rows, which rows are successively arranged in a widthwise direction. Each row has a plurality of micro lenses, with each micro lens having a resolution field. Each micro lens is adapted to receive light from the illuminated region of the sample and to produce a beam of light. Each row includes a first micro lens and the first micro lens in each successive row is offset from the first micro lens in the previous row by a predetermined amount extending in the lengthwise direction. The offset between successive rows aligns the resolution fields of the micro lenses to collectively create a continuous resolution field across the length of the lens array. The positioning system moves the lens array and image detector relative to the sample, or vice versa, or both. The image processor produces an image signal indicative of the illuminated region of the sample produced from data signals from the image detector.

摘要翻译： 提供了一种生物样品成像方法和装置。 该装置包括至少一个光源，至少一个透镜阵列，至少一个图像检测器，定位系统和图像处理器。 透镜阵列具有多个纵向延伸的行，这些行在宽度方向上连续布置。 每行具有多个微透镜，每个微透镜具有分辨率场。 每个微透镜适于接收来自样品的照射区域的光并产生光束。 每行包括第一微透镜，并且每个连续行中的第一微透镜在前一行中偏离了在长度方向上延伸的预定量的第一微透镜。 连续行之间的偏移将微透镜的分辨率场对准以在透镜阵列的长度上共同形成连续的分辨率场。 定位系统相对于样品移动透镜阵列和图像检测器，反之亦然，或两者都相同。 图像处理器产生指示从图像检测器的数据信号产生的样本的照明区域的图像信号。

公开(公告)号：US08421903B2

公开(公告)日：2013-04-16

申请号：US12776797

申请日：2010-05-10

申请人： Shaohong Wang ,  Carlos Barnes Gonzalez

发明人： Shaohong Wang ,  Carlos Barnes Gonzalez

IPC分类号： H04N5/225

CPC分类号： G01N21/6458 ,  G01N21/64 ,  G01N2201/0806

摘要： A method and an apparatus for imaging a biologic sample is provided. The apparatus includes at least one light source, at least one lens array, at least one image detector, a positioning system, and an image processor. The lens array has a plurality of lengthwise extending rows, which rows are successively arranged in a widthwise direction. Each row has a plurality of micro lenses, with each micro lens having a resolution field. Each micro lens is adapted to receive light from the illuminated region of the sample and to produce a beam of light. Each row includes a first micro lens and the first micro lens in each successive row is offset from the first micro lens in the previous row by a predetermined amount extending in the lengthwise direction. The offset between successive rows aligns the resolution fields of the micro lenses to collectively create a continuous resolution field across the length of the lens array. The positioning system moves the lens array and image detector relative to the sample, or vice versa, or both. The image processor produces an image signal indicative of the illuminated region of the sample produced from data signals from the image detector.

摘要翻译： 提供了一种生物样品成像方法和装置。 该装置包括至少一个光源，至少一个透镜阵列，至少一个图像检测器，定位系统和图像处理器。 透镜阵列具有多个纵向延伸的行，这些行在宽度方向上连续布置。 每行具有多个微透镜，每个微透镜具有分辨率场。 每个微透镜适于接收来自样品的照射区域的光并产生光束。 每行包括第一微透镜，并且每个连续行中的第一微透镜在前一行中偏离了在长度方向上延伸的预定量的第一微透镜。 连续行之间的偏移将微透镜的分辨率场对准以在透镜阵列的长度上共同形成连续的分辨率场。 定位系统相对于样品移动透镜阵列和图像检测器，反之亦然，或两者都相同。 图像处理器产生指示从图像检测器的数据信号产生的样本的照明区域的图像信号。

公开(公告)号：US08837803B2

公开(公告)日：2014-09-16

申请号：US12982422

申请日：2010-12-30

申请人： Zhizhou Wang ,  Min Xie ,  Anil Patil ,  Chong Chen ,  Shaohong Wang ,  Cord Mueller

发明人： Zhizhou Wang ,  Min Xie ,  Anil Patil ,  Chong Chen ,  Shaohong Wang ,  Cord Mueller

IPC分类号： G06K9/00 ,  G01N33/49

CPC分类号： G01N33/49

摘要： A method and apparatus for determining a cell volume of a red blood cell is provided. The method includes the steps of: a) depositing a sample into an analysis chamber, the chamber defined by an first panel interior surface, a second panel interior surface, and a known or determinable height, which height is such that at least one red blood cell subject to a sphering agent assumes a partially compressed spherical shape in contact with the interior surfaces; b) imaging the at least one partially compressed spherical red blood cell contacting the interior surfaces, and producing image signals; c) determining a radius of the partially compressed spherical red blood cell from the image signals; and d) determining a volume of the imaged red blood cell using the determined radius.

摘要翻译： 提供了一种用于确定红细胞的细胞体积的方法和装置。 该方法包括以下步骤：a）将样品沉积到分析室中，所述室由第一面板内表面，第二面板内表面和已知或可确定的高度限定，所述高度使得至少一个红血 经受球形剂的细胞呈现与内表面接触的部分压缩球形; b）对与内表面接触的至少一个部分压缩的球形红细胞进行成像，并产生图像信号; c）根据图像信号确定部分压缩的球形红细胞的半径; 以及d）使用确定的半径来确定成像的红细胞的体积。

公开(公告)号：US07119339B2

公开(公告)日：2006-10-10

申请号：US10844105

申请日：2004-05-12

申请人： Bradley Stuart Ferguson ,  Shaohong Wang ,  Xi-Cheng Zhang

发明人： Bradley Stuart Ferguson ,  Shaohong Wang ,  Xi-Cheng Zhang

IPC分类号： G01J5/28 ,  H01L31/00 ,  G01R31/308 ,  G01N21/17 ,  G01N21/63

CPC分类号： G01N21/3581

摘要： A method of obtaining a series of images of a three-dimensional object by transmitting pulsed terahertz (THz) radiation through the entire object from a plurality of angles, optically detecting changes in the transmitted THz radiation using pulsed laser radiation, and constructing a plurality of imaged slices of the three-dimensional object using the detected changes in the transmitted THz radiation. The THz radiation is transmitted through the object as a scanning spot. The object is placed within the Rayleigh range of the focused THz beam and a focusing system is used to transfer the imaging plane from adjacent the object to a desired distance away from the object. A related system is also disclosed.

摘要翻译： 一种通过从多个角度通过整个物体传输脉冲太赫兹（THz）辐射而获得三维物体的一系列图像的方法，使用脉冲激光辐射光学地检测所发射的太赫兹辐射的变化，以及构建多个 使用检测到的发射的THz辐射的变化来成像三维物体的切片。 太赫兹辐射作为扫描点透过物体。 该物体被放置在聚焦的太赫兹束的瑞利范围内，并且使用聚焦系统将成像平面从邻近的物体传送到离物体所需的距离。 还公开了相关系统。

公开(公告)号：US20050023470A1

公开(公告)日：2005-02-03

申请号：US10844105

申请日：2004-05-12

申请人： Bradley Ferguson ,  Shaohong Wang ,  Xi-Cheng Zhang

发明人： Bradley Ferguson ,  Shaohong Wang ,  Xi-Cheng Zhang

IPC分类号： G01N21/35 ,  G01N21/63

CPC分类号： G01N21/3581

摘要： A method of obtaining a series of images of a three-dimensional object by transmitting pulsed terahertz (THz) radiation through the entire object from a plurality of angles, optically detecting changes in the transmitted THz radiation using pulsed laser radiation, and constructing a plurality of imaged slices of the three-dimensional object using the detected changes in the transmitted THz radiation. The THz radiation is transmitted through the object as a scanning spot. The object is placed within the Rayleigh range of the focused THz beam and a focusing system is used to transfer the imaging plane from adjacent the object to a desired distance away from the object. A related system is also disclosed.

摘要翻译： 一种通过从多个角度通过整个物体传输脉冲太赫兹（THz）辐射来获得三维物体的一系列图像的方法，利用脉冲激光辐射光学检测所传输的太赫兹辐射的变化，以及构建多个 使用检测到的发射的THz辐射的变化来成像三维物体的切片。 太赫兹辐射作为扫描点透过物体。 该物体被放置在聚焦的太赫兹束的瑞利范围内，并且使用聚焦系统将成像平面从邻近的物体传送到离物体所需的距离。 还公开了相关系统。

公开(公告)号：USD1040235S1

公开(公告)日：2024-08-27

申请号：US29937491

申请日：2024-04-15

申请人： Shaohong Wang

设计人： Shaohong Wang

摘要： FIG. 1 is a bottom, front, right side perspective view of a toy, showing my new design;
FIG. 2 is a top, rear, left side perspective view thereof;
FIG. 3 is a front view thereof;
FIG. 4 is a rear view thereof;
FIG. 5 is a left side view thereof;
FIG. 6 is a right side view thereof;
FIG. 7 is a top view thereof; and,
FIG. 8 is a bottom view thereof.
The broken lines in the drawings depict portions of the toy that form no part of the claimed design.

公开(公告)号：US20110164803A1

公开(公告)日：2011-07-07

申请号：US12982422

申请日：2010-12-30

申请人： Zhizhou Wang ,  Min Xie ,  Anil Patil ,  Chong Chen ,  Shaohong Wang ,  Cord Mueller

发明人： Zhizhou Wang ,  Min Xie ,  Anil Patil ,  Chong Chen ,  Shaohong Wang ,  Cord Mueller

IPC分类号： G06K9/00

CPC分类号： G01N33/49

摘要： A method and apparatus for determining a cell volume of a red blood cell is provided. The method includes the steps of: a) depositing a sample into an analysis chamber, the chamber defined by an first panel interior surface, a second panel interior surface, and a known or determinable height, which height is such that at least one red blood cell subject to a sphering agent assumes a partially compressed spherical shape in contact with the interior surfaces; b) imaging the at least one partially compressed spherical red blood cell contacting the interior surfaces, and producing image signals; c) determining a radius of the partially compressed spherical red blood cell from the image signals; and d) determining a volume of the imaged red blood cell using the determined radius.

摘要翻译： 提供了一种用于确定红细胞的细胞体积的方法和装置。 该方法包括以下步骤：a）将样品沉积到分析室中，所述室由第一面板内表面，第二面板内表面和已知或可确定的高度限定，所述高度使得至少一个红血 经受球形剂的细胞呈现与内表面接触的部分压缩球形; b）对与内表面接触的至少一个部分压缩的球形红细胞进行成像，并产生图像信号; c）根据图像信号确定部分压缩的球形红细胞的半径; 以及d）使用确定的半径来确定成像的红细胞的体积。

公开(公告)号：US07129491B2

公开(公告)日：2006-10-31

申请号：US10843899

申请日：2004-05-12

申请人： Bradley Ferguson ,  Shaohong Wang ,  Xi-Cheng Zhang

发明人： Bradley Ferguson ,  Shaohong Wang ,  Xi-Cheng Zhang

IPC分类号： G01J5/02

CPC分类号： G01N21/3581 ,  G01N21/4795

摘要： A method of obtaining a series of images of a three-dimensional object. The method includes the steps of transmitting pulsed terahertz (THz) radiation through the entire object from a plurality of angles, optically detecting changes in the transmitted THz radiation using pulsed laser radiation, and constructing a plurality of imaged slices of the three-dimensional object using the detected changes in the transmitted THz radiation. The THz radiation is transmitted through the object as a two-dimensional array of parallel rays. The optical detection is an array of detectors such as a CCD sensor.

摘要翻译： 一种获得三维物体的一系列图像的方法。 该方法包括以下步骤：从多个角度通过整个物体传输脉冲太赫兹（THz）辐射;使用脉冲激光辐射光学地检测所发射的太赫兹辐射的变化;以及使用以下步骤构建所述三维物体的多个成像切片 检测到的传输太赫兹辐射的变化。 太赫兹辐射通过物体作为平行光线的二维阵列传播。 光学检测是诸如CCD传感器的检测器阵列。