公开(公告)号：US10947525B2

公开(公告)日：2021-03-16

申请号：US16556665

申请日：2019-08-30

Applicant: Carnegie Mellon University

Inventor： Alan J. Russell ,  Hironobu Murata ,  Chad S. Cummings ,  Richard R. Koepsel

IPC: C12N9/96 ,  A61K38/46 ,  C12N9/16 ,  A61K47/58 ,  C12N11/08 ,  A61K38/48 ,  C12N9/76

Abstract: Embodiments of the invention provide at least one polymer covalently conjugated to an esterase. The at least one polymer includes a plurality of oxime functional groups.

公开(公告)号：US10400232B2

公开(公告)日：2019-09-03

申请号：US15026093

申请日：2014-10-03

Applicant: Carnegie Mellon University

Inventor： Alan J. Russell ,  Hironobu Murata ,  Chad Cummings ,  Richard R. Koepsel

IPC: C12N9/96 ,  A61K38/46 ,  C12N9/16 ,  A61K38/48 ,  C12N9/76 ,  A61K47/58

Abstract: Embodiments of the invention provide at least one polymer covalently conjugated to an esterase. The at least one polymer includes a plurality of oxime functional groups.

公开(公告)号：US20210403897A1

公开(公告)日：2021-12-30

申请号：US17290032

申请日：2019-10-30

Applicant: Carnegie Mellon University

Inventor： Weihang Ji ,  Richard R. Koepsel ,  Alan J. Russell

IPC: C12N11/089 ,  C12N5/00 ,  A61K47/69 ,  A61K47/64 ,  A61K47/60

Abstract: Methods and materials for generating and using complexes that contain erythrocytes coupled to polypeptides, and particularly to erythrocyte-polypeptide complexes that can interact with biological molecules, are provided herein.

公开(公告)号：US10954506B2

公开(公告)日：2021-03-23

申请号：US16556739

申请日：2019-08-30

Applicant: Carnegie Mellon University

Inventor： Alan J. Russell ,  Hironobu Murata ,  Chad S. Cummings ,  Richard R. Koepsel

IPC: C12N9/96 ,  A61K38/46 ,  C12N9/16 ,  A61K47/58 ,  C12N11/08 ,  A61K38/48 ,  C12N9/76

Abstract: Embodiments of the invention provide at least one polymer covalently conjugated to an esterase. The at least one polymer includes a plurality of oxime functional groups.

公开(公告)号：US20190382748A1

公开(公告)日：2019-12-19

申请号：US16556665

申请日：2019-08-30

Applicant: Carnegie Mellon University

Inventor： Alan J. Russell ,  Hironobu Murata ,  Chad S. Cummings ,  Richard R. Koepsel

IPC: C12N9/96 ,  A61K38/46 ,  C12N9/16 ,  A61K38/48 ,  C12N9/76 ,  A61K47/58

Abstract: Embodiments of the invention provide at least one polymer covalently conjugated to an esterase. The at least one polymer includes a plurality of oxime functional groups.

公开(公告)号：US20190382749A1

公开(公告)日：2019-12-19

申请号：US16556739

申请日：2019-08-30

Applicant: Carnegie Mellon University

Inventor： Alan J. Russell ,  Hironobu Murata ,  Chad S. Cummings ,  Richard R. Koepsel

IPC: C12N9/96 ,  A61K38/46 ,  A61K38/48 ,  C12N9/16 ,  C12N9/76 ,  A61K47/58

Abstract: Embodiments of the invention provide at least one polymer covalently conjugated to an esterase. The at least one polymer includes a plurality of oxime functional groups.

公开(公告)号：US20160244741A1

公开(公告)日：2016-08-25

申请号：US15026093

申请日：2014-10-03

Applicant: CARNEGIE MELLON UNIVERSITY

Inventor： Alan J. Russell ,  Hironobu Murata ,  Chad Cummings ,  Richard R. Koepsel

IPC: C12N9/96 ,  A61K38/48 ,  A61K47/48 ,  C12N9/76 ,  C12N9/16 ,  A61K38/46

CPC classification number: C12N9/96 ,  A61K38/465 ,  A61K38/4826 ,  A61K47/58 ,  C12N9/16 ,  C12N9/6427 ,  C12Y301/01007 ,  C12Y304/21001

Abstract: Embodiments of the invention provide at least one polymer covalently conjugated to an esterase. The at least one polymer includes a plurality of oxime functional groups.

Abstract translation: 本发明的实施方案提供至少一种与酯酶共价缀合的聚合物。 所述至少一种聚合物包括多个肟官能团。