公开(公告)号：US20070249694A1

公开(公告)日：2007-10-25

申请号：US11648309

申请日：2006-12-29

申请人： Caroline Azaria ,  Gershon Kolatkar ,  Mira Kopel ,  Fanny Leska ,  Ilan Zalit

发明人： Caroline Azaria ,  Gershon Kolatkar ,  Mira Kopel ,  Fanny Leska ,  Ilan Zalit

IPC分类号： A61K31/42

CPC分类号： A61K9/2027 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/2077 ,  A61K31/42 ,  A61K31/421 ,  A61K47/02 ,  A61K47/10 ,  A61K47/16

摘要： The invention provides pharmaceutical metaxalone compositions having improved bioavailability, food effect, and/or relative food effect, as well as methods of making such metaxalone compositions.

摘要翻译： 本发明提供了具有改善的生物利用度，食物效应和/或相对食物效应的药物美他沙酮组合物以及制备这种美他沙酮组合物的方法。

公开(公告)号：US08367106B2

公开(公告)日：2013-02-05

申请号：US11481962

申请日：2006-07-07

申请人： Ilan Zalit ,  Fanny Leska ,  Mali Kadosh ,  Dorit Marco ,  Yonit Messer-Triger

发明人： Ilan Zalit ,  Fanny Leska ,  Mali Kadosh ,  Dorit Marco ,  Yonit Messer-Triger

IPC分类号： A61K9/20 ,  A61K31/66

CPC分类号： A61K9/2077 ,  A61K9/2059 ,  A61K31/445 ,  A61K31/55

摘要： A pharmaceutical formulation of compounds with low aqueous solubility and method of manufacture thereof. The formulation may include a pharmacologically active compound having low aqueous solubility and starch in the amount of greater than about 25 weight percent. A manufacturing method may include blending the active compound and starch, compressing the blend into a solid, comminuting the solid into granules, wetting the granules, drying the granules, and tabletting the dried granules to make a solid pharmaceutical formulation.

公开(公告)号：US20070248684A1

公开(公告)日：2007-10-25

申请号：US11701180

申请日：2007-01-31

申请人： Sigal Blau ,  Ilan Zalit ,  Gershon Kolatkar ,  Carolina Azaria

发明人： Sigal Blau ,  Ilan Zalit ,  Gershon Kolatkar ,  Carolina Azaria

IPC分类号： A61K9/16

CPC分类号： A61K9/1652 ,  A61K9/1623 ,  A61K9/1635

摘要： The present invention provides a pharmaceutical composition comprising oxcarbazepine and at least one pharmaceutical excipient, wherein the oxcarbazepine in the composition has a broad particle size distribution. The broad particle size distribution of oxcarbazepine in the pharmaceutical composition is preferably a multi-modal oxcarbazepine particle size distribution, preferably with an enhanced oxcarbazepine dissolution rate.

摘要翻译： 本发明提供了包含奥卡西平和至少一种药物赋形剂的药物组合物，其中组合物中奥卡西平具有宽的粒度分布。 药物组合物中奥卡西平的宽粒度分布优选为多模态奥卡西平粒度分布，优选具有增强的奥卡西平溶解速率。

公开(公告)号：US20120045488A1

公开(公告)日：2012-02-23

申请号：US13284454

申请日：2011-10-28

申请人： Ilan Zalit ,  Fanny Leska ,  Mali Kadosh ,  Dorit Marco ,  Yonit Messer-Triger

发明人： Ilan Zalit ,  Fanny Leska ,  Mali Kadosh ,  Dorit Marco ,  Yonit Messer-Triger

IPC分类号： A61K31/4535 ,  A61P19/10 ,  A61K9/14

CPC分类号： A61K9/2077 ,  A61K9/2059 ,  A61K31/445 ,  A61K31/55

摘要： A pharmaceutical formulation of compounds with low aqueous solubility and method of manufacture thereof. The formulation may include a pharmacologically active compound having low aqueous solubility and starch in the amount of greater than about 25 weight percent. A manufacturing method may include blending the active compound and starch, compressing the blend into a solid, comminuting the solid into granules, wetting the granules, drying the granules, and tabletting the dried granules to make a solid pharmaceutical formulation.

摘要翻译： 低溶解度的化合物的药物制剂及其制造方法。 制剂可以包含具有低水溶性的药理活性化合物和大于约25重量％的量的淀粉。 制造方法可以包括混合活性化合物和淀粉，将共混物压制成固体，将固体粉碎成颗粒，润湿颗粒，干燥颗粒，并将干燥的颗粒压片以制成固体药物制剂。

公开(公告)号：US08597666B2

公开(公告)日：2013-12-03

申请号：US13284454

申请日：2011-10-28

申请人： Ilan Zalit ,  Fanny Leska ,  Mali Kadosh ,  Dorit Marco ,  Yonit Messer-Triger

发明人： Ilan Zalit ,  Fanny Leska ,  Mali Kadosh ,  Dorit Marco ,  Yonit Messer-Triger

IPC分类号： A61K9/00 ,  A61K9/64 ,  A61K31/445 ,  A61K9/20 ,  A61K31/55 ,  A61K31/40

CPC分类号： A61K9/2077 ,  A61K9/2059 ,  A61K31/445 ,  A61K31/55

摘要： A pharmaceutical formulation of compounds with low aqueous solubility and method of manufacture thereof. The formulation may include a pharmacologically active compound having low aqueous solubility and starch in the amount of greater than about 25 weight percent. A manufacturing method may include blending the active compound and starch, compressing the blend into a solid, comminuting the solid into granules, wetting the granules, drying the granules, and tabletting the dried granules to make a solid pharmaceutical formulation.

摘要翻译： 低溶解度的化合物的药物制剂及其制造方法。 制剂可以包含具有低水溶性的药理活性化合物和大于约25重量％的量的淀粉。 制造方法可以包括混合活性化合物和淀粉，将共混物压制成固体，将固体粉碎成颗粒，润湿颗粒，干燥颗粒，并将干燥的颗粒压片以制成固体药物制剂。

公开(公告)号：US20060099252A1

公开(公告)日：2006-05-11

申请号：US10986494

申请日：2004-11-10

申请人： Ilan Zalit ,  Fanny Leska ,  Mali Kadosh ,  Dorit Marco ,  Yonit Messer-Triger

发明人： Ilan Zalit ,  Fanny Leska ,  Mali Kadosh ,  Dorit Marco ,  Yonit Messer-Triger

IPC分类号： A61K31/55 ,  A61K31/445 ,  A61K9/20

CPC分类号： A61K9/2077 ,  A61K9/2059 ,  A61K31/445 ,  A61K31/55

摘要： A pharmaceutical formulation of compounds with low aqueous solubility and method of manufacture thereof. The formulation may include a pharmacologically active compound having low aqueous solubility and starch in the amount of greater than about 25 weight percent. A manufacturing method may include blending the active compound and starch, compressing the blend into a solid, comminuting the solid into granules, wetting the granules, drying the granules, and tabletting the dried granules to make a solid pharmaceutical formulation.

公开(公告)号：US08367105B2

公开(公告)日：2013-02-05

申请号：US10986494

申请日：2004-11-10

申请人： Ilan Zalit ,  Fanny Leska ,  Mali Kadosh ,  Dorit Marco ,  Yonit Messer-Triger

发明人： Ilan Zalit ,  Fanny Leska ,  Mali Kadosh ,  Dorit Marco ,  Yonit Messer-Triger

IPC分类号： A61K31/55 ,  A61K31/445 ,  A61K9/20 ,  A61K9/64 ,  A01N43/00 ,  A01N43/40 ,  A01N43/36

CPC分类号： A61K9/2077 ,  A61K9/2059 ,  A61K31/445 ,  A61K31/55

摘要： A pharmaceutical formulation of compounds with low aqueous solubility and method of manufacture thereof. The formulation may include a pharmacologically active compound having low aqueous solubility and starch in the amount of greater than about 25 weight percent. A manufacturing method may include blending the active compound and starch, compressing the blend into a solid, comminuting the solid into granules, wetting the granules, drying the granules, and tabletting the dried granules to make a solid pharmaceutical formulation.

公开(公告)号：US20060251718A1

公开(公告)日：2006-11-09

申请号：US11481962

申请日：2006-07-07

申请人： Ilan Zalit ,  Fanny Leska ,  Mali Kadosh ,  Dorit Marco ,  Yonit Messer-Triger

发明人： Ilan Zalit ,  Fanny Leska ,  Mali Kadosh ,  Dorit Marco ,  Yonit Messer-Triger

IPC分类号： A61K31/445 ,  A61K9/20

CPC分类号： A61K9/2077 ,  A61K9/2059 ,  A61K31/445 ,  A61K31/55

摘要： A pharmaceutical formulation of compounds with low aqueous solubility and method of manufacture thereof. The formulation may include a pharmacologically active compound having low aqueous solubility and starch in the amount of greater than about 25 weight percent. A manufacturing method may include blending the active compound and starch, compressing the blend into a solid, comminuting the solid into granules, wetting the granules, drying the granules, and tabletting the dried granules to make a solid pharmaceutical formulation.

公开(公告)号：US20070148245A1

公开(公告)日：2007-06-28

申请号：US11317824

申请日：2005-12-22

申请人： Ilan Zalit ,  Mira Kopel

发明人： Ilan Zalit ,  Mira Kopel

IPC分类号： A61K9/14

CPC分类号： A61K9/2077 ,  A61K9/1623 ,  A61K9/2018

摘要： One of the objects of the present invention is directed to a process of preparing a pharmaceutical formulation of a drug of low aqueous solubility, comprising (A) fixing the drug in a strong matrix comprising at least one at least partially amorphous sugar to obtain a sugar-drug matrix; and (B) milling the sugar-drug matrix to obtain a milled sugar-drug matrix as the pharmaceutical formulation. The invention also provides the pharmaceutical formulation prepared by the process.

摘要翻译： 本发明的目的之一涉及制备低溶解度药物的药物制剂的方法，其包括（A）将药物固定在包含至少一种至少部分无定形糖的强基质中以获得糖 药物基质 和（B）研磨糖 - 药物基质以获得作为药物制剂的碾磨的糖 - 药物基质。 本发明还提供了通过该方法制备的药物制剂。

公开(公告)号：US20090068262A1

公开(公告)日：2009-03-12

申请号：US12080761

申请日：2008-04-03

申请人： Ilan Zalit ,  Uri Zadok

发明人： Ilan Zalit ,  Uri Zadok

IPC分类号： A61K31/404 ,  A61K9/20 ,  A61P29/00

CPC分类号： A61K9/2072 ,  A61K9/2095 ,  A61K31/4045 ,  A61K45/06 ,  A61K2300/00

摘要： Provided are rapidly dissolving pharmaceutical oral dosage forms of triptans and NSAIDs, processes for the preparation thereof, and methods of treatment therewith.

摘要翻译： 提供快速溶解的曲安奈德和NSAID的药物口服剂型，其制备方法及其治疗方法。