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公开(公告)号：US10512796B2
公开(公告)日：2019-12-24
申请号：US13500937
申请日：2010-12-30
申请人： Ofer Toledano , Haim Bar-Simantov , Hanan Sertchook , Sharon Fireman-Shoresh , Dorit Marco-Dagan
发明人： Ofer Toledano , Haim Bar-Simantov , Hanan Sertchook , Sharon Fireman-Shoresh , Dorit Marco-Dagan
IPC分类号： A01N25/28 , A61Q19/00 , A61K8/11 , A61K8/25 , A61K8/26 , A61K8/38 , A61K8/67 , A61K9/00 , A61K9/51 , B01J13/14
摘要： The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within a metal oxide shell, processes for their preparations, comparisons comprising them and uses thereof.
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公开(公告)号：US08367106B2
公开(公告)日：2013-02-05
申请号：US11481962
申请日：2006-07-07
申请人： Ilan Zalit , Fanny Leska , Mali Kadosh , Dorit Marco , Yonit Messer-Triger
发明人： Ilan Zalit , Fanny Leska , Mali Kadosh , Dorit Marco , Yonit Messer-Triger
CPC分类号： A61K9/2077 , A61K9/2059 , A61K31/445 , A61K31/55
摘要： A pharmaceutical formulation of compounds with low aqueous solubility and method of manufacture thereof. The formulation may include a pharmacologically active compound having low aqueous solubility and starch in the amount of greater than about 25 weight percent. A manufacturing method may include blending the active compound and starch, compressing the blend into a solid, comminuting the solid into granules, wetting the granules, drying the granules, and tabletting the dried granules to make a solid pharmaceutical formulation.
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3.发明申请公开(公告)号：US20120045488A1
公开(公告)日：2012-02-23
申请号：US13284454
申请日：2011-10-28
申请人： Ilan Zalit , Fanny Leska , Mali Kadosh , Dorit Marco , Yonit Messer-Triger
发明人： Ilan Zalit , Fanny Leska , Mali Kadosh , Dorit Marco , Yonit Messer-Triger
IPC分类号： A61K31/4535 , A61P19/10 , A61K9/14
CPC分类号： A61K9/2077 , A61K9/2059 , A61K31/445 , A61K31/55
摘要： A pharmaceutical formulation of compounds with low aqueous solubility and method of manufacture thereof. The formulation may include a pharmacologically active compound having low aqueous solubility and starch in the amount of greater than about 25 weight percent. A manufacturing method may include blending the active compound and starch, compressing the blend into a solid, comminuting the solid into granules, wetting the granules, drying the granules, and tabletting the dried granules to make a solid pharmaceutical formulation.
摘要翻译： 低溶解度的化合物的药物制剂及其制造方法。 制剂可以包含具有低水溶性的药理活性化合物和大于约25重量％的量的淀粉。 制造方法可以包括混合活性化合物和淀粉，将共混物压制成固体，将固体粉碎成颗粒，润湿颗粒，干燥颗粒，并将干燥的颗粒压片以制成固体药物制剂。
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公开(公告)号：US08367105B2
公开(公告)日：2013-02-05
申请号：US10986494
申请日：2004-11-10
申请人： Ilan Zalit , Fanny Leska , Mali Kadosh , Dorit Marco , Yonit Messer-Triger
发明人： Ilan Zalit , Fanny Leska , Mali Kadosh , Dorit Marco , Yonit Messer-Triger
CPC分类号： A61K9/2077 , A61K9/2059 , A61K31/445 , A61K31/55
摘要： A pharmaceutical formulation of compounds with low aqueous solubility and method of manufacture thereof. The formulation may include a pharmacologically active compound having low aqueous solubility and starch in the amount of greater than about 25 weight percent. A manufacturing method may include blending the active compound and starch, compressing the blend into a solid, comminuting the solid into granules, wetting the granules, drying the granules, and tabletting the dried granules to make a solid pharmaceutical formulation.
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5.发明申请公开(公告)号：US20120202695A1
公开(公告)日：2012-08-09
申请号：US13500937
申请日：2010-12-30
申请人： Ofer Toledano , Haim Bar-Simantov , Hanan Sertchook , Sharon Fireman-Shoresh , Dorit Marco-Dagan
发明人： Ofer Toledano , Haim Bar-Simantov , Hanan Sertchook , Sharon Fireman-Shoresh , Dorit Marco-Dagan
IPC分类号： A01N25/28 , A61K8/11 , A61K31/327 , A61K31/19 , A61P31/10 , A61P31/04 , A61P29/00 , A61P17/04 , A61P17/06 , A61P17/10 , A61P17/00 , A61P17/08 , A01P13/00 , A01P1/00 , A01P7/04 , A61K9/50
CPC分类号： A61Q19/00 , A61K8/11 , A61K8/25 , A61K8/26 , A61K8/38 , A61K8/671 , A61K9/0014 , A61K9/5115 , A61K9/5192 , A61K2800/412 , B01J13/14
摘要： The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within a metal oxide shell, processes for their preparations, comparisons comprising them and uses thereof.
摘要翻译： 本发明提供核心稳定的微胶囊，其中所述核包含包封在金属氧化物壳内的至少一种活性剂，其制备方法，包含它们的比较及其用途。
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公开(公告)号：US20060251718A1
公开(公告)日：2006-11-09
申请号：US11481962
申请日：2006-07-07
申请人： Ilan Zalit , Fanny Leska , Mali Kadosh , Dorit Marco , Yonit Messer-Triger
发明人： Ilan Zalit , Fanny Leska , Mali Kadosh , Dorit Marco , Yonit Messer-Triger
IPC分类号： A61K31/445 , A61K9/20
CPC分类号： A61K9/2077 , A61K9/2059 , A61K31/445 , A61K31/55
摘要： A pharmaceutical formulation of compounds with low aqueous solubility and method of manufacture thereof. The formulation may include a pharmacologically active compound having low aqueous solubility and starch in the amount of greater than about 25 weight percent. A manufacturing method may include blending the active compound and starch, compressing the blend into a solid, comminuting the solid into granules, wetting the granules, drying the granules, and tabletting the dried granules to make a solid pharmaceutical formulation.
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7.发明授权公开(公告)号：US08597666B2
公开(公告)日：2013-12-03
申请号：US13284454
申请日：2011-10-28
申请人： Ilan Zalit , Fanny Leska , Mali Kadosh , Dorit Marco , Yonit Messer-Triger
发明人： Ilan Zalit , Fanny Leska , Mali Kadosh , Dorit Marco , Yonit Messer-Triger
CPC分类号： A61K9/2077 , A61K9/2059 , A61K31/445 , A61K31/55
摘要： A pharmaceutical formulation of compounds with low aqueous solubility and method of manufacture thereof. The formulation may include a pharmacologically active compound having low aqueous solubility and starch in the amount of greater than about 25 weight percent. A manufacturing method may include blending the active compound and starch, compressing the blend into a solid, comminuting the solid into granules, wetting the granules, drying the granules, and tabletting the dried granules to make a solid pharmaceutical formulation.
摘要翻译： 低溶解度的化合物的药物制剂及其制造方法。 制剂可以包含具有低水溶性的药理活性化合物和大于约25重量％的量的淀粉。 制造方法可以包括混合活性化合物和淀粉，将共混物压制成固体，将固体粉碎成颗粒，润湿颗粒，干燥颗粒，并将干燥的颗粒压片以制成固体药物制剂。
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公开(公告)号：US20060099252A1
公开(公告)日：2006-05-11
申请号：US10986494
申请日：2004-11-10
申请人： Ilan Zalit , Fanny Leska , Mali Kadosh , Dorit Marco , Yonit Messer-Triger
发明人： Ilan Zalit , Fanny Leska , Mali Kadosh , Dorit Marco , Yonit Messer-Triger
IPC分类号： A61K31/55 , A61K31/445 , A61K9/20
CPC分类号： A61K9/2077 , A61K9/2059 , A61K31/445 , A61K31/55
摘要： A pharmaceutical formulation of compounds with low aqueous solubility and method of manufacture thereof. The formulation may include a pharmacologically active compound having low aqueous solubility and starch in the amount of greater than about 25 weight percent. A manufacturing method may include blending the active compound and starch, compressing the blend into a solid, comminuting the solid into granules, wetting the granules, drying the granules, and tabletting the dried granules to make a solid pharmaceutical formulation.
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