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公开(公告)号：US09096837B2
公开(公告)日：2015-08-04
申请号：US13008619
申请日：2011-01-18
CPC分类号： C12N9/2417 , C07K2299/00 , C12Y302/01001
摘要： The present disclosure relates to variants (mutants) of polypeptides, in particular Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits an alteration in at least one of the following properties relative to said parent alpha-amylase: substrate specificity, substrate binding, substrate cleavage pattern, thermal stability, pH/activity profile, pH/stability profile, stability towards oxidation, Ca2+ dependency, specific activity, in particular laundry and dish-wash applications.
摘要翻译： 本公开涉及多肽的变体（突变体），特别是类戊酰样α-淀粉酶，该变体具有α-淀粉酶活性，并且相对于所述亲本α-淀粉酶在至少一个以下性质中发生改变：底物特异性 ，底物结合，底物切割模式，热稳定性，pH /活性分布，pH /稳定性分布，对氧化的稳定性，Ca 2+依赖性，比活性，特别是洗衣和洗碗应用。
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公开(公告)号：US20080193999A1
公开(公告)日：2008-08-14
申请号：US11571708
申请日：2005-07-05
CPC分类号： C12N9/2417 , C07K2299/00 , C12Y302/01001
摘要： The present invention relates to variants (mutants) of polypeptides, in particular Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits an alteration in at least one of the following properties relative to said parent alpha-amylase: substrate specificity, substrate binding, substrate cleavage pattern, thermal stability, pH/activity profile, pH/stability profile, stability towards oxidation, Ca2+ dependency, specific activity, in particular laundry and dish-wash applications.
摘要翻译： 本发明涉及多肽的变体（突变体），特别是类戊酰样α-淀粉酶，该变体具有α-淀粉酶活性并且相对于所述亲本α-淀粉酶在至少一个以下性质中具有改变：底物特异性 ，底物结合，底物切割模式，热稳定性，pH /活性分布，pH /稳定性分布，对氧化的稳定性，Ca 2+依赖性，比活性，特别是洗衣和洗碗应用。
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公开(公告)号：US20110136205A1
公开(公告)日：2011-06-09
申请号：US13008619
申请日：2011-01-18
CPC分类号： C12N9/2417 , C07K2299/00 , C12Y302/01001
摘要： The present invention relates to variants (mutants) of polypeptides, in particular Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits an alteration in at least one of the following properties relative to said parent alpha-amylase: substrate specificity, substrate binding, substrate cleavage pattern, thermal stability, pH/activity profile, pH/stability profile, stability towards oxidation, Ca2+ dependency, specific activity, in particular laundry and dish-wash applications.
摘要翻译： 本发明涉及多肽的变体（突变体），特别是类戊酰样α-淀粉酶，该变体具有α-淀粉酶活性并且相对于所述亲本α-淀粉酶在至少一个以下性质中具有改变：底物特异性 ，底物结合，底物切割模式，热稳定性，pH /活性分布，pH /稳定性分布，对氧化的稳定性，Ca 2+依赖性，比活性，特别是洗衣和洗碗应用。
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公开(公告)号：US09434932B2
公开(公告)日：2016-09-06
申请号：US14129565
申请日：2012-06-29
申请人： Svend Kaasgaard , Jens Oebro , Signe Eskildsen Larsen , Allan Svendsen , Annette Helle Johansen , Michael Skjoet , Carsten Andersen , Lars Beier , Esben Peter Friis , Miguel Duarte Guilherme Pereira Toscano , Mads Bjoernvad , Frank Winther Rasmussen , Liv Spaanger Christiansen
发明人： Svend Kaasgaard , Jens Oebro , Signe Eskildsen Larsen , Allan Svendsen , Annette Helle Johansen , Michael Skjoet , Carsten Andersen , Lars Beier , Esben Peter Friis , Miguel Duarte Guilherme Pereira Toscano , Mads Bjoernvad , Frank Winther Rasmussen , Liv Spaanger Christiansen
IPC分类号： C12N9/28
CPC分类号： C12N9/2417 , C12Y302/01001
摘要： The present invention relates to variants of a parent alpha-amylase. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
摘要翻译： 本发明涉及母体α-淀粉酶的变体。 本发明还涉及编码这些变体的多核苷酸; 核酸构建体，载体和包含多核苷酸的宿主细胞; 以及使用这些变体的方法。
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公开(公告)号：US08986668B2
公开(公告)日：2015-03-24
申请号：US11921199
申请日：2006-06-01
申请人： Carsten Andersen
发明人： Carsten Andersen
IPC分类号： A61K9/68 , A61K31/465 , A61K47/48
CPC分类号： A61K47/48184 , A61K9/0058 , A61K31/465 , A61K47/585
摘要： A method of manufacturing a nicotine delivery product comprising nicotine and a cation exchange resin. More precisely, to a method for preparing a nicotine delivery product said method comprising (a) mixing nicotine, a cation exchange resin, an organic polyol and water to form a mixture wherein the total amount of water is from 26 to 45% by weight of the total mixture, and (b) removing water from the mixture to produce said nicotine delivery product.
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公开(公告)号：US08858919B2
公开(公告)日：2014-10-14
申请号：US13963480
申请日：2013-08-09
申请人： Carsten Andersen
发明人： Carsten Andersen
IPC分类号： A61K9/58 , A61K31/465 , A61K9/68
CPC分类号： A61K31/465 , A61K9/0058
摘要： The invention relates to a method of relieving nicotine craving comprising the steps of providing at least one chewing gum comprising tobacco alkaloid to a user, providing relief of nicotine craving to said user by transferring of tobacco alkaloid from the chewing gum to the human body of said user by chewing of said chewing gum, said chewing of said chewing gum comprising a chewing process involving a transfer of tobacco alkaloid from said chewing gum above a threshold transfer rate in the period of about ½ minute to about 2½ minutes from initiation of said chewing process.
摘要翻译： 本发明涉及一种减轻尼古丁渴望的方法，包括以下步骤：向使用者提供包含烟草生物碱的至少一种口香糖，通过将烟草生物碱从口香糖转移到所述口腔内的人体，使所述使用者缓解尼古丁渴望 所述咀嚼口咀嚼所述口香糖，所述咀嚼口香糖包括咀嚼方法，所述咀嚼方法涉及在所述咀嚼过程开始之后约1/2分钟至约2.5分钟的时间内从所述口香糖转移烟草生物碱高于阈值转移速率 。
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公开(公告)号：US08741935B2
公开(公告)日：2014-06-03
申请号：US10581628
申请日：2004-12-02
申请人： Carsten Andersen
发明人： Carsten Andersen
IPC分类号： A61K9/68 , A61K31/4439 , A61P25/34
CPC分类号： A24B15/10 , A24B15/287 , A61K9/0058 , A61K31/465 , A61K47/10 , A61K47/585
摘要： A nicotine delivery product comprising the reaction product of a nicotine/cation exchange resin complex and an organic polyol; and a method for preparing it comprising (a) mixing an aqueous suspension of a nicotine/cation exchange resin complex with an organic polyol or an aqueous solution thereof, and (b) removing water from the mixture to produce said nicotine delivery product. The nicotine delivery product has a nicotine release rate of at least 80% over a 10 minute period. It is particularly suited for use in smoking substitution devices delivering nicotine such as chewing gum, patches, lozenges, melting tablets and tablets for chewing.
摘要翻译： 尼古丁输送产物，其包含尼古丁/阳离子交换树脂复合物和有机多元醇的反应产物; 及其制备方法，包括（a）将尼古丁/阳离子交换树脂配合物的水悬浮液与有机多元醇或其水溶液混合，和（b）从混合物中除去水以产生所述尼古丁递送产物。 尼古丁递送产品在10分钟内具有至少80％的尼古丁释放率。 它特别适用于提供尼古丁的吸烟替代装置，例如口香糖，贴剂，锭剂，熔化片和片剂用于咀嚼。
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8.发明授权Processes for preparing a dough or a baked product using maltogenic alpha-amylase variants 有权使用产麦芽糖α-淀粉酶变体制备面团或烘焙产品的方法公开(公告)号：US08546099B2
公开(公告)日：2013-10-01
申请号：US13533055
申请日：2012-06-26
CPC分类号： C12N9/2417 , A21D2/26 , A21D8/042
摘要： The inventors have modified the amino acid sequence of a maltogenic alpha-amylase to obtain variants with improved properties, based on the three-dimensional structure of the maltogenic alpha-amylase Novamyl. The variants have altered physicochemical properties, e.g. an altered pH optimum, improved thermostability, increased specific activity, an altered cleavage pattern or an increased ability to reduce retrogradation of starch or staling of bread.
摘要翻译： 基于麦芽糖α-淀粉酶Novamyl的三维结构，本发明人已经修饰了产麦芽糖α-淀粉酶的氨基酸序列以获得具有改进性质的变体。 这些变体具有改变的物理化学性质，例如 改变的pH最佳，改善的热稳定性，增加的比活性，改变的切割模式或增加降低淀粉退化或面包陈化的能力。
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公开(公告)号：US08460656B2
公开(公告)日：2013-06-11
申请号：US12294526
申请日：2007-03-19
CPC分类号： C12N9/16 , A23K20/189 , C12Y301/03
摘要： The present invention relates to a phytase which has at least 80% identity to a phytase derived from Citrobacter braakii and comprises at least one alteration when compared to this phytase. These phytase variants have amended, preferably improved, properties, such as thermostability, temperature profile, pH profile, specific activity, performance in animal feed, reduced protease sensitiliby, and/or an amended glycosylation pattern. The invention also relates to DNA encoding these phytases, methods of their production, as well as the use thereof, e.g. in animal feed and animal feed additives.
摘要翻译： 本发明涉及一种植酸酶，其与来自柠檬酸杆菌的植酸酶具有至少80％的同一性，并且与该植酸酶相比包含至少一个变化。 这些植酸酶变体具有修饰，优选改进的性质，例如热稳定性，温度曲线，pH曲线，比活性，动物饲料中的性能，降低的蛋白酶敏感性和/或修饰的糖基化模式。 本发明还涉及编码这些植酸酶的DNA，其生产方法及其用途，例如， 在动物饲料和动物饲料添加剂中。
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公开(公告)号：US08440444B2
公开(公告)日：2013-05-14
申请号：US13289634
申请日：2011-11-04
摘要： The present invention relates to hybrid polypeptides having a first amino acid sequence having endo-amylase activity and a second amino acid sequence having carbohydrate binding activity. The present invention also relates to the use of the hybrid polypeptides in starch processing and baking.
摘要翻译： 本发明涉及具有内切淀粉酶活性的第一氨基酸序列和具有碳水化合物结合活性的第二个氨基酸序列的杂合多肽。 本发明还涉及杂交多肽在淀粉加工和烘烤中的用途。
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