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公开(公告)号：US20240344030A1
公开(公告)日：2024-10-17
申请号：US18292670
申请日：2022-07-28
发明人： Yi Zhang , C. Andrew Stewart , Metin Kurtoglu , Sjaji Daniel , Murat V. Kalayoglu , Minhtran Ngo Casi
IPC分类号： C12N5/0775 , C07K14/54 , C07K14/715 , C07K16/28 , C12N15/85
CPC分类号： C12N5/0662 , C07K14/5434 , C07K14/7158 , C07K16/2809 , C07K16/2878 , C12N15/85 , C07K2317/24 , C07K2317/31 , C07K2317/92 , C12N2800/107
摘要： Provided here are cells engineered for therapeutic purposes to express multiple proteins, including an anti-BCMA (B cell maturation antigen), anti-CD3 bispecific antibody. Also provided are new anti-BCMA, anti-CD3 bispecific antibodies with associated sequences. Further disclosed is a mesenchymal stem cell (MSC) comprising an exogenous mRNA encoding an anti-BCMA and anti-CD3 antibody, and an exogenous mRNA encoding a single-chain interleukin-12 (IL-12) fusion protein.
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公开(公告)号：US11999773B2
公开(公告)日：2024-06-04
申请号：US17540947
申请日：2021-12-02
IPC分类号： C07K16/28 , A61K39/395 , C07K14/705 , C07K16/30 , A61K39/00 , C07K14/715
CPC分类号： C07K14/70517 , A61K39/3955 , A61K39/39558 , C07K16/2878 , C07K16/2896 , C07K16/30 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/53 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/03
摘要： Provided herein are chimeric antigen receptors (CARs), such as those specific for BCMA, that have improved properties, including increased CAR T cell binding to BCMA and improved CAR T cell killing of BCMA-expressing cancer cells. Use of the CARs in immune cells (e.g., T cells), compositions (e.g., CARs and nucleic acid constructs encoding the same), and methods are also contemplated.
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公开(公告)号：US11220535B2
公开(公告)日：2022-01-11
申请号：US17156407
申请日：2021-01-22
IPC分类号： C07K16/28 , C07K16/30 , C07K14/705 , A61K39/395 , C07K14/715 , A61K39/00
摘要： Provided herein are chimeric antigen receptors (CARs), such as those specific for BCMA, that have improved properties, including increased CAR T cell binding to BCMA and improved CAR T cell killing of BCMA-expressing cancer cells. Use of the CARs in immune cells (e.g., T cells), compositions (e.g., CARs and nucleic acid constructs encoding the same), and methods are also contemplated.
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公开(公告)号：US20210221868A1
公开(公告)日：2021-07-22
申请号：US17156407
申请日：2021-01-22
IPC分类号： C07K14/705 , C07K16/28 , C07K16/30 , A61K39/395
摘要： Provided herein are chimeric antigen receptors (CARs), such as those specific for BCMA, that have improved properties, including increased CAR T cell binding to BCMA and improved CAR T cell killing of BCMA-expressing cancer cells. Use of the CARs in immune cells (e.g., T cells), compositions (e.g., CARs and nucleic acid constructs encoding the same), and methods are also contemplated.
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公开(公告)号：US20240294600A1
公开(公告)日：2024-09-05
申请号：US18654279
申请日：2024-05-03
IPC分类号： C07K14/705 , A61K39/00 , A61K39/395 , C07K16/28 , C07K16/30
CPC分类号： C07K14/70517 , A61K39/3955 , A61K39/39558 , C07K16/2878 , C07K16/2896 , C07K16/30 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/53 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/03
摘要： Provided herein are chimeric antigen receptors (CARs), such as those specific for BCMA, that have improved properties, including increased CAR T cell binding to BCMA and improved CAR T cell killing of BCMA-expressing cancer cells. Use of the CARs in immune cells (e.g., T cells), compositions (e.g., CARs and nucleic acid constructs encoding the same), and methods are also contemplated.
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公开(公告)号：US20220089678A1
公开(公告)日：2022-03-24
申请号：US17540947
申请日：2021-12-02
IPC分类号： C07K14/705 , C07K16/28 , C07K16/30 , A61K39/395
摘要： Provided herein are chimeric antigen receptors (CARs), such as those specific for BCMA, that have improved properties, including increased CAR T cell binding to BCMA and improved CAR T cell killing of BCMA-expressing cancer cells. Use of the CARs in immune cells (e.g., T cells), compositions (e.g., CARs and nucleic acid constructs encoding the same), and methods are also contemplated.
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公开(公告)号：US20200291087A1
公开(公告)日：2020-09-17
申请号：US16825996
申请日：2020-03-20
IPC分类号： C07K14/705 , C07K16/28
摘要： Provided herein are chimeric antigen receptors (CARs), such as those specific for BCMA, that have improved properties, including increased CAR T cell binding to BCMA and improved CAR T cell killing of BCMA-expressing cancer cells. Use of the CARs in immune cells (e.g., T cells), compositions (e.g., CARs and nucleic acid constructs encoding the same), and methods are also contemplated.
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公开(公告)号：US20230174944A1
公开(公告)日：2023-06-08
申请号：US17919092
申请日：2021-04-15
IPC分类号： C12N5/0775 , C12N9/22 , C07K16/28
CPC分类号： C12N5/0662 , C12N9/22 , C12Y301/21001 , C07K16/2878
摘要： Provided herein are mammalian cells comprising a first exogenous nucleic acid encoding a DNAse protein and a second exogenous nucleic acid encoding another DNAse protein, such as DNASE1 protein and DNASE1L3 protein, that have improved properties, including the ability to degrades extracellular chromatin and remove Neutrophil Extracellular Traps (NETs). Use of these cells, including the use in the treatment of a subject in need thereof, is also contemplated.
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公开(公告)号：US10934337B2
公开(公告)日：2021-03-02
申请号：US16825996
申请日：2020-03-20
IPC分类号： C07K16/28 , C07K16/30 , C07K14/705 , A61K39/395 , A61K39/00
摘要： Provided herein are chimeric antigen receptors (CARs), such as those specific for BCMA, that have improved properties, including increased CAR T cell binding to BCMA and improved CAR T cell killing of BCMA-expressing cancer cells. Use of the CARs in immune cells (e.g., T cells), compositions (e.g., CARs and nucleic acid constructs encoding the same), and methods are also contemplated.
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