-
1.发明授权Method of targeting a specific location in a body using phospholipid and cholesterol liposomes which encapsulate an agent 失效使用封装药剂的磷脂和胆固醇脂质体靶向体内特定位置的方法公开(公告)号：US06274115B1
公开(公告)日：2001-08-14
申请号：US08483494
申请日：1995-06-07
申请人： Cary A. Presant , Richard T. Proffitt , Raymond L. Teplitz , Lawrence E. Williams , George W. Tin
发明人： Cary A. Presant , Richard T. Proffitt , Raymond L. Teplitz , Lawrence E. Williams , George W. Tin
IPC分类号： A61K5100
CPC分类号： A61K9/1271 , A61K51/1234 , A61K2121/00 , A61K2123/00 , Y10S436/829
摘要： Micellular particles such as small unilamellar vesicles of less than 2000 A° loaded with 111In are administered to BALB/c mice in which EMT6 tumors had been induced. Whole body scintographs of the mice to which either neutral or positively or negatively charged vesicles had been administered show a substantial quantity of the vesicle entrapped 111In localized in the tumor. Blocking of macrophages in the liver and spleen by first administering unlabeled, aminomannose substituted vesicles before administration of the labeled vesicles increases uptake of the 111In labeled vesicles in the tumor.
摘要翻译： 将具有小于2000A的小单层囊泡的胶束颗粒（装载有111In）施用于已经诱导EMT6肿瘤的BALB / c小鼠。 已经施用中性或正性或带负电荷的小泡的小鼠的全身阴影图显示了定量存在于肿瘤中的大量囊泡111I。 在施用标记的囊泡之前首先施用未标记的氨基甘露糖糖溶液取代的囊泡，在肝脏和脾脏中阻断巨噬细胞增加肿瘤中111I标记的囊泡的摄取
-
公开(公告)号：US5435989A
公开(公告)日：1995-07-25
申请号：US663503
申请日：1984-10-22
申请人： Cary A. Presant , Richard T. Proffitt , Raymond L. Teplitz , Lawrence E. Williams , George W. Tin
发明人： Cary A. Presant , Richard T. Proffitt , Raymond L. Teplitz , Lawrence E. Williams , George W. Tin
CPC分类号： A61K9/1271 , A61K51/1234 , A61K2121/00 , A61K2123/00 , Y10S436/829
摘要： Micellular particles such as small unilamellar vesicles of less than 2000 .ANG. loaded with .sup.111 In are administered to BALB/c mice in which EMT6 tumors had been induced. Whole body scintographs of the mice to which either neutral or positively or negatively charged vesicles had been administered show a substantial quantity of the vesicle entrapped .sup.111 In localized in the tumor. Blocking of macrophages in the liver and spleen by first administering unlabeled, aminomannose substituted vesicles before administration of the labeled vesicles increases uptake of the .sup.111 In labeled vesicles in the tumor.
摘要翻译： 将具有小于2000个ANGSTROM的小单层囊泡的胶束颗粒施用于已经诱导EMT6肿瘤的BALB / c小鼠。 已经施用中性或正性或带负电荷的小泡的小鼠的全身阴影图显示了定量存在于肿瘤中的大量囊泡111I。 在施用标记的囊泡之前首先施用未标记的氨基甘露糖取代的囊泡，在肝脏和脾脏中阻断巨噬细胞增加了肿瘤中111I标记的囊泡的摄取。
-
3.发明授权Method of delivering micellular particles encapsulating chemotherapeutic agents to tumors in a body 失效将包封化学治疗剂的胶束颗粒递送到体内的肿瘤的方法
公开(公告)号：US5441745A
公开(公告)日：1995-08-15
申请号：US663550
申请日：1984-10-22
申请人： Cary A. Presant , Richard T. Proffitt , Raymond L. Teplitz , Lawrence E. Williams , George W. Tin
发明人： Cary A. Presant , Richard T. Proffitt , Raymond L. Teplitz , Lawrence E. Williams , George W. Tin
CPC分类号： A61K9/1271 , A61K51/1234 , A61K2121/00 , A61K2123/00 , Y10S436/829
摘要： A method is provided for delivering micellular particles containing chemotherapeutic agents and a marker to tumors within a body for the diagnosis and treatment of such tumors. The micellular particles are small, less than 2000 .ANG. and incorporate pure, neutral phospholipid molecules in their external surface. Enhanced delivery of the micellular particles containing marker and chemotherapeutic agents may be achieved by introducing an initial group of positively charged micellular particles to block the reticuloendothelial cells present in the body.
摘要翻译： 提供了一种用于将包含化学治疗剂的微粒颗粒和用于诊断和治疗这样的肿瘤的体内的肿瘤的标记递送到该体内的方法。 胶束颗粒小，小于2000 ANGSTROM，并在其外表面掺入纯中性磷脂分子。 通过引入带正电荷的微胶粒的初始组来阻止存在于体内的网状内皮细胞，可以实现含有标记物和化学治疗剂的胶束颗粒的增强递送。
-
公开(公告)号：US5019369A
公开(公告)日：1991-05-28
申请号：US279316
申请日：1988-12-01
CPC分类号： A61K9/1271 , A61K51/1234 , A61K2121/00 , A61K2123/00 , Y10S436/829 , Y10T428/2984
摘要： A method is provided for delivering micellular particles containing a radiolabelled marker to tumors within humans. The micellular particles are less than approximately 2000.ANG. and incorporate essentially chemically pure phospholipid molecules in their external surface. Human patients given intravenous injections of such radiolabelled micellular particles showed tumors imaged by such method, without developing symptoms related to the micellular particles.
摘要翻译： 提供了一种用于将含有放射性标记的标记物的微粒颗粒递送到人体内的肿瘤的方法。 胶束颗粒小于约2000，并在其外表面上基本上化学纯化的磷脂分子。 给予静脉注射这种放射性标记的胶束颗粒的人类患者显示通过这种方法成像的肿瘤，而不发展与微胶粒颗粒相关的症状。
-
公开(公告)号：US5756120A
公开(公告)日：1998-05-26
申请号：US468497
申请日：1995-06-06
CPC分类号： A61K31/7036 , A61K9/127
摘要： A liposomal aminoglycoside formulation comprising a neutral lipid, a negatively charged lipids and a sterol. The formulation contains unilamellar vesicles having an average size below 100 nm. A process of making liposomes containing an aminoglycoside is provided where the hydration temperature is significantly below the transition temperature of the formulation. A method for the treatment of drug susceptible and drug resistant bacteria.
摘要翻译： 包含中性脂质，带负电荷的脂质和固醇的脂质体氨基糖苷制剂。 该制剂含有平均粒度低于100nm的单层囊泡。 提供了含有氨基糖苷类的脂质体的方法，其中水合温度明显低于制剂的转变温度。 一种治疗药物易感和耐药细菌的方法。
-
公开(公告)号：US06221388B1
公开(公告)日：2001-04-24
申请号：US09407798
申请日：1999-09-28
IPC分类号： A61K9127
CPC分类号： A61K31/7036 , A61K9/127 , A61K9/1272
摘要： A liposomal aminoglycoside formulation comprising a neutral lipid, a negatively charged lipids and a sterol. The formulation contains unilamellar vesicles having an average size below 100 nm. A process of making liposomes containing an aminoglycoside is also provided. A method is also provided for the treatment of drug susceptible and drug resistant bacteria.
摘要翻译： 包含中性脂质，带负电荷的脂质和固醇的脂质体氨基糖苷制剂。 该制剂含有平均粒度低于100nm的单层囊泡。 还提供了制备含有氨基糖苷类的脂质体的方法。 还提供了用于治疗药物易感和耐药细菌的方法。
-
7.发明授权
公开(公告)号：US5874104A
公开(公告)日：1999-02-23
申请号：US467864
申请日：1995-06-06
CPC分类号： A61K9/1271 , A61K31/7048 , B82Y5/00
摘要： Formulations consisting of phospholipid small unilamellar particles encapsulating polyene antifungal antibiotics and methods for using such compositions to treat systemic fungal infections are described. In a preferred embodiment, the particles are in the form of vesicles which comprise a polyene antifungal antibiotic, preferably amphotericin B and/or nystatin, egg phosphatidylcholine and cholesterol, preferably in the molar ratio of about 0.2 (AMB):2(PL):1(CHOL). These vesicles may also have an amine modified surface. The vesicles are suspended in a low isonic strength saccharide/tris solution at a pH of from about 6.0 to about 8.0 and may be administered to deliver the antifungal antibiotic to treat systemic fungal infections.
摘要翻译： 描述由包含多烯抗真菌抗生素的磷脂小单层颗粒组成的制剂以及使用这些组合物治疗全身性真菌感染的方法。 在优选的实施方案中，颗粒是囊泡形式，其包含多烯抗真菌抗生素，优选两性霉素B和/或制霉菌素，卵磷脂酰胆碱和胆固醇，优选摩尔比为约0.2（AMB）：2（PL）： 1（CHOL）。 这些囊泡也可以具有胺改性的表面。 将囊泡悬浮在pH为约6.0至约8.0的低等强度糖/ tris溶液中，并且可以施用以输送抗真菌抗生素以治疗全身性真菌感染。
-
8.发明授权Preparation small unilamellar vesicles including polyene antifungal antibiotics 失效制备小单层囊泡，包括多烯抗真菌抗生素
公开(公告)号：US5043107A
公开(公告)日：1991-08-27
申请号：US427732
申请日：1989-10-27
CPC分类号： A61K9/1271 , A61K31/7048 , Y10S436/829 , Y10S514/885 , Y10T428/2984
摘要： Formulations consisting of phospholipid small unilamellar particles encapsulating polyene antifungal antibiotics and methods for using such compositions to treat systemic fungal infections are described. In a preferred embodiment, the particles are in the form of vesicles which comprise a polyene antifungal antibiotic, preferably amphotericin B and/or nystatin, egg phosphatidylcholine and cholesterol, preferably in the molar ratio of about 0.2 (AMB):2(PL):1(CHOL). These vesicles may also have an amine modified surface. The vesicles are suspended in a low ionic strength saccharide/tris solution at a pH of from about 6.0 to about 8.0 and may be administered to deliver the anti-fungal antibiotic to treat systemic fungal infections.
摘要翻译： 描述由包含多烯抗真菌抗生素的磷脂小单层颗粒组成的制剂以及使用这些组合物治疗全身性真菌感染的方法。 在优选的实施方案中，颗粒是囊泡形式，其包含多烯抗真菌抗生素，优选两性霉素B和/或制霉菌素，卵磷脂酰胆碱和胆固醇，优选摩尔比为约0.2（AMB）：2（PL）： 1（CHOL）。 这些囊泡也可以具有胺改性的表面。 将囊泡悬浮在约6.0至约8.0的pH下的低离子强度的糖/三溶液中，并且可以施用以递送抗真菌抗生素以治疗全身性真菌感染。
-
公开(公告)号：US5958449A
公开(公告)日：1999-09-28
申请号：US82633
申请日：1998-05-21
CPC分类号： A61K31/7036 , A61K9/127 , A61K9/1272
摘要： A liposomal aminoglycoside formulation comprising a neutral lipid, a negatively charged lipid and a sterol. The formulation contains unilamellar vesicles having an average size below 100 nm. A process of making liposomes containing an aminoglycoside is provided. A method is also provide for the treatment of drug susceptible and drug resistant bacteria.
摘要翻译： 包含中性脂质，带负电荷的脂质和甾醇的脂质体氨基糖苷制剂。 该制剂含有平均粒度低于100nm的单层囊泡。 提供了制备含有氨基糖苷类的脂质体的方法。 还提供了用于治疗药物易感和耐药细菌的方法。
-
公开(公告)号：US06770290B1
公开(公告)日：2004-08-03
申请号：US07600154
申请日：1990-10-19
IPC分类号： A61K9127
CPC分类号： A61K9/1277 , A61K31/7048 , A61K47/544 , B82Y5/00
摘要： A novel composition and method for solubilizing amphiphilic drugs in a small amount of organic solvent for use in improved liposomes is disclosed. A phosphatidylglycerol is acidified in a small amount of organic solvent. The amphiphilic drug, such as Amphotericin B, suspended in organic solvent is then added to the acidified phosphatidylycerol and a soluble complex is formed between the phosphatidylglycerol and the amphiphilic drug. When the liposome composition incorporating the soluble complex is hydrated, the final pH of the hydrating aqueous buffer is carefully controlled. The Amphotericin B liposomes formed have markedly reduced toxicity.
-
-
-
-
-
-
-
-
-
搜索结果
12 条记录 (耗时 0.028 秒)
