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35 条记录 (耗时 0.071 秒)

    Benzothiadiazolylphenylalkylamine derivatives and methods of their use
    8.
    发明授权
    Benzothiadiazolylphenylalkylamine derivatives and methods of their use 失效
    苯并噻二唑基苯基烷基胺衍生物及其使用方法

    公开(公告)号：US07601744B2

    公开(公告)日：2009-10-13

    申请号：US11528792

    申请日：2006-09-27

    申请人： Casey Cameron McComas ,  Puwen Zhang ,  Eugene John Trybulski ,  An Thien Vu ,  Eugene Anthony Terefenko

    发明人： Casey Cameron McComas ,  Puwen Zhang ,  Eugene John Trybulski ,  An Thien Vu ,  Eugene Anthony Terefenko

    IPC分类号： A61K31/41 ,  C07D285/06

    CPC分类号： C07D285/14

    摘要： The present invention is directed to benzothiadiazolylphenylalkylamine derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromyalgia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.

    摘要翻译： 本发明涉及式I的苯并噻二唑基苯基烷基胺衍生物：或其药学上可接受的盐，含有这些衍生物的组合物及其用于预防和治疗由单胺再摄取改善的病症的方法，所述方法尤其包括血管舒缩症状（VMS） 特别是选自重症抑郁障碍，血管舒缩症状，压力和急迫性尿失禁，纤维肌痛，疼痛等的那些病症，其中，所述疾病，性功能障碍，胃肠道和泌尿生殖系统疾病，慢性疲劳综合征，纤维肌痛综合征，神经系统疾病及其组合， 糖尿病性神经病变及其组合。

    Substituted propylamine derivatives and methods of their use
    9.
    发明授权
    Substituted propylamine derivatives and methods of their use 失效
    取代的丙胺衍生物及其使用方法

    公开(公告)号：US07687529B2

    公开(公告)日：2010-03-30

    申请号：US11529450

    申请日：2006-09-27

    申请人： Casey Cameron McComas ,  Puwen Zhang ,  Eugene Anthony Terefenko ,  An Thien Vu ,  Stephen Todd Cohn

    发明人： Casey Cameron McComas ,  Puwen Zhang ,  Eugene Anthony Terefenko ,  An Thien Vu ,  Stephen Todd Cohn

    IPC分类号： A61K31/4184 ,  C07D235/04 ,  C07D209/04

    CPC分类号： C07D209/96 ,  C07D209/08 ,  C07D209/34 ,  C07D235/26 ,  C07D235/30 ,  C07D277/68

    摘要： The present invention is directed to substituted propylamine derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.

    摘要翻译： 本发明涉及式I的取代丙胺衍生物：或其药学上可接受的盐，含有这些衍生物的组合物及其用于预防和治疗由单胺再摄取改善的病症的方法，其中尤其包括血管舒缩症状（VMS） 特别是那些选自重症抑郁障碍，血管舒缩症状，压力和急迫性尿失禁，纤维肌痛，疼痛等症状的那些疾病 ，糖尿病性神经病，及其组合。