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公开(公告)号：US08691517B2
公开(公告)日：2014-04-08
申请号：US12085961
申请日：2006-12-06
IPC分类号： G01N33/543 , G01N33/542 , G01N33/66 , A61B5/145
CPC分类号： C08B37/0063 , A61B5/145 , A61B5/14532 , G01N33/54373 , G01N33/66
摘要： A sensor for the detection or measurement of a carbohydrate analyte in fluid comprises components of a competitive binding assay the readout of which is a detectable or measurable optical signal retained by a material that permits diffusion of the analyte but not the assay components, the assay components comprising: a carbohydrate binding molecule labelled with one of a proximity based signal generating/modulating moiety pair; and a carbohydrate analogue capable of competing with the analyte for binding to the carbohydrate binding molecule, the carbohydrate analogue being a flexible water-soluble polymer comprising: polymerized or co-polymerised residues of monomer units, the monomer unit residues bearing pendant carbohydrate or carbohydrate mimetic moieties and pendant moieties which are the other of the proximity based signal generating/modulating moiety pair.
摘要翻译： 用于检测或测量流体中的碳水化合物分析物的传感器包括竞争性结合测定的组分，其读出是由允许分析物扩散但不含测定组分的测定组分保留的可检测或可测量的光学信号，测定组分 包括：用接近度信号产生/调节部分对之一标记的碳水化合物结合分子; 碳水化合物类似物是柔性水溶性聚合物，其包含：单体单元的聚合或共聚残基，带有碳水化合物或碳水化合物模拟物的单体单元残基 部分和侧基部分，其是基于邻近的信号产生/调节部分对中的另一个。
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公开(公告)号：US20090187084A1
公开(公告)日：2009-07-23
申请号：US12085961
申请日：2006-12-06
IPC分类号： A61B5/1455 , G01N33/53 , C07H15/00
CPC分类号： C08B37/0063 , A61B5/145 , A61B5/14532 , G01N33/54373 , G01N33/66
摘要： A sensor for the detection or measurement of a carbohydrate analyte in fluid comprises components of a competitive binding assay the readout of which is a detectable or measurable optical signal retained by a material that permits diffusion of the analyte but not the assay components, the assay components comprising: a carbohydrate binding molecule labelled with one of a proximity based signal generating/modulating moiety pair; and a carbohydrate analogue capable of competing with the analyte for binding to the carbohydrate binding molecule, the carbohydrate analogue being a flexible water-soluble polymer comprising: polymerized or co-polymerised residues of monomer units, the monomer unit residues bearing pendant carbohydrate or carbohydrate mimetic moieties and pendant moieties which are the other of the proximity based signal generating/modulating moiety pair.
摘要翻译： 用于检测或测量流体中的碳水化合物分析物的传感器包括竞争性结合测定的组分，其读出是由允许分析物扩散但不含测定组分的测定组分保留的可检测或可测量的光学信号，测定组分 包括：用接近度信号产生/调节部分对之一标记的碳水化合物结合分子; 碳水化合物类似物是柔性水溶性聚合物，其包含：单体单元的聚合或共聚残基，带有碳水化合物或碳水化合物模拟物的单体单元残基 部分和侧基部分，其是基于邻近的信号产生/调节部分对中的另一个。
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公开(公告)号：US08700113B2
公开(公告)日：2014-04-15
申请号：US11791924
申请日：2005-12-07
申请人： Jesper Svenning Kristensen , Klaus Gregorius , Casper Struve , John Myhre Frederiksen , Yihua Yu
发明人： Jesper Svenning Kristensen , Klaus Gregorius , Casper Struve , John Myhre Frederiksen , Yihua Yu
IPC分类号： A61B5/1455
CPC分类号： C08B37/0063 , A61B5/145 , A61B5/14532 , G01N33/54373 , G01N33/66
摘要： A sensor for the detection or measurement of carbohydrate analyte (such as glucose) in fluid comprises components of a competitive binding assay the readout of which is a detectable or measurable optical signal (such as FRET assay) retained by a material that permits diffusion of analyte but not the assay components, the assay components comprising: an animal lectin; and an analyte analogue capable of competing with analyte for binding to the lectin.
摘要翻译： 用于检测或测量流体中碳水化合物分析物（例如葡萄糖）的传感器包括竞争性结合测定的组分，其读出是可检测或可测量的光学信号（例如FRET测定），其由允许分析物扩散的材料保留 但不是测定组分，测定组分包含：动物凝集素; 以及能够与分析物竞争结合凝集素的分析物类似物。
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公开(公告)号：US08478375B2
公开(公告)日：2013-07-02
申请号：US11792046
申请日：2005-12-07
IPC分类号： A61B5/1455 , C12Q1/68
CPC分类号： G01N33/54373
摘要： A sensor for sensing analyte concentration comprises at least two different variants of an appropriate competitive binding assay, the sensor being capable of sensing accurately a required range of analyte concentrations by means of the variants of the assay each being capable of sensing accurately a part only of the required range of analyte concentrations and the variants of the assay being chosen to sense overlapping or adjoining ranges of concentration covering the whole of the required range.
摘要翻译： 用于感测分析物浓度的传感器包括适当竞争性结合测定的至少两种不同变体，所述传感器能够通过所述测定的变体精确地感测分析物浓度的所需范围，所述变体各自能够精确地仅感测部分 分析物浓度的所需范围和测定的变体被选择以感测覆盖整个所需范围的重叠或相邻的浓度范围。
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公开(公告)号：US20090131773A1
公开(公告)日：2009-05-21
申请号：US11792046
申请日：2005-12-07
IPC分类号： A61B5/1459 , A61B5/145
CPC分类号： G01N33/54373
摘要： A sensor for sensing analyte concentration comprises at least two different variants of an appropriate competitive binding assay, the sensor being capable of sensing accurately a required range of analyte concentrations by means of the variants of the assay each being capable of sensing accurately a part only of the required range of analyte concentrations and the variants of the assay being chosen to sense overlapping or adjoining ranges of concentration covering the whole of the required range.
摘要翻译： 用于感测分析物浓度的传感器包括适当竞争性结合测定的至少两种不同变体，所述传感器能够通过所述测定的变体精确地感测分析物浓度的所需范围，所述变体各自能够精确地仅感测部分 分析物浓度的所需范围和测定的变体被选择以感测覆盖整个所需范围的重叠或相邻的浓度范围。
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公开(公告)号：US20080188723A1
公开(公告)日：2008-08-07
申请号：US11791924
申请日：2005-12-07
申请人： Jesper Svennin Kristensen , Klaus Gregorius , Casper Struve , John Myhre Frederiksen , Yihua Yu
发明人： Jesper Svennin Kristensen , Klaus Gregorius , Casper Struve , John Myhre Frederiksen , Yihua Yu
IPC分类号： A61B5/1455
CPC分类号： C08B37/0063 , A61B5/145 , A61B5/14532 , G01N33/54373 , G01N33/66
摘要： A sensor for the detection or measurement of carbohydrate analyte (such as glucose) in fluid comprises components of a competitive binding assay the readout of which is a detectable or measurable optical signal (such as FRET assay) retained by a material that permits diffusion of analyte but not the assay components, the assay components comprising: an animal lectin; and an analyte analogue capable of competing with analyte for binding to the lectin.
摘要翻译： 用于检测或测量流体中碳水化合物分析物（例如葡萄糖）的传感器包括竞争性结合测定的组分，其读出是可检测或可测量的光学信号（例如FRET测定），其由允许分析物扩散的材料保留 但不是测定组分，测定组分包含：动物凝集素; 以及能够与分析物竞争结合凝集素的分析物类似物。
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