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1.发明申请Nucleic acids, polypeptides, compositions, and methods for modulating apoptosis 失效核酸，多肽，组合物和调节凋亡的方法公开(公告)号：US20070059831A1
公开(公告)日：2007-03-15
申请号：US11595990
申请日：2006-11-13
申请人： Catherine Taylor , Tzann-Wei Wang , Larry Petrov , John Carlson , Richard Narayansingh , Marianne Kaup , Dominic Cliche , John Thompson
发明人： Catherine Taylor , Tzann-Wei Wang , Larry Petrov , John Carlson , Richard Narayansingh , Marianne Kaup , Dominic Cliche , John Thompson
IPC分类号： C12N15/86
CPC分类号： C07K14/4747 , C12N9/0004 , C12Q1/6876 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to isolated and/or purified rat apoptosis-specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The present invention also relates to methods of modulating apoptosis using apoptosis-specific eIF-5A and DHS, and antisense oligonucleotides and expression vectors of apoptosis-specific eIF-5A and DHS useful in such methods.
摘要翻译： 本发明涉及分离和/或纯化的大鼠凋亡特异性真核启动因子5A（eIF-5A）和脱氧螺旋体合成酶（DHS）核酸和多肽。 本发明还涉及使用凋亡特异性eIF-5A和DHS调节凋亡的方法，以及用于这些方法的反义寡核苷酸和凋亡特异性eIF-5A和DHS的表达载体。
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2.发明申请Nucleic Acids, Polypeptides, Compositions, and Methods for Modulating Apoptosis 审中-公开核酸，多肽，组合物和调节细胞凋亡的方法公开(公告)号：US20120064625A1
公开(公告)日：2012-03-15
申请号：US13007137
申请日：2011-01-14
申请人： Catherine Taylor , Tzann-Wei Wang , Larry Petrov , John C. Carlson , Richard Narayansingh , Marianne Kaup , Dominic Cliche , John E. Thompson
发明人： Catherine Taylor , Tzann-Wei Wang , Larry Petrov , John C. Carlson , Richard Narayansingh , Marianne Kaup , Dominic Cliche , John E. Thompson
CPC分类号： C07K14/4747 , C12N9/0004 , C12Q1/6876 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to isolated and/or purified rat apoptosis-specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The present invention also relates to methods of modulating apoptosis using apoptosis-specific eIF-5A and DHS, and antisense oligonucleotides and expression vectors of apoptosis-specific eIF-5A and DHS useful in such methods.
摘要翻译： 本发明涉及分离和/或纯化的大鼠凋亡特异性真核启动因子5A（eIF-5A）和脱氧螺旋体合成酶（DHS）核酸和多肽。 本发明还涉及使用凋亡特异性eIF-5A和DHS调节凋亡的方法，以及用于这些方法的反义寡核苷酸和凋亡特异性eIF-5A和DHS的表达载体。
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公开(公告)号：US07166467B2
公开(公告)日：2007-01-23
申请号：US10141647
申请日：2002-05-07
申请人： Catherine Taylor , Tzann-Wei Wang , Larry Petrov , John C. Carlson , Richard Narayansingh , Marianne Kaup , Dominic Cliche , John E. Thompson
发明人： Catherine Taylor , Tzann-Wei Wang , Larry Petrov , John C. Carlson , Richard Narayansingh , Marianne Kaup , Dominic Cliche , John E. Thompson
IPC分类号： C12N15/85
CPC分类号： C07K14/4747 , C12N9/0004 , C12Q1/6876 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to isolated and/or purified rat apoptosis-specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The present invention also relates to methods of modulating apoptosis using apoptosis-specific eIF-5A and DHS, and antisense oligonucleotides and expression vectors of apoptosis-specific eIF-5A and DHS useful in such methods.
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公开(公告)号：US07872112B2
公开(公告)日：2011-01-18
申请号：US11595990
申请日：2006-11-13
申请人： Catherine A. Taylor , Tzann-Wei Wang , Larry Petrov , John C. Carlson , Richard Narayansingh , Marianne Kaup , Dominic Cliche , John E. Thompson
发明人： Catherine A. Taylor , Tzann-Wei Wang , Larry Petrov , John C. Carlson , Richard Narayansingh , Marianne Kaup , Dominic Cliche , John E. Thompson
IPC分类号： C07H21/04
CPC分类号： C07K14/4747 , C12N9/0004 , C12Q1/6876 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to isolated and/or purified rat apoptosis-specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The present invention also relates to methods of modulating apoptosis using apoptosis-specific eIF-5A and DHS, and antisense oligonucleotides and expression vectors of apoptosis-specific eIF-5A and DHS useful in such methods.
摘要翻译： 本发明涉及分离和/或纯化的大鼠凋亡特异性真核启动因子5A（eIF-5A）和脱氧螺旋体合成酶（DHS）核酸和多肽。 本发明还涉及使用凋亡特异性eIF-5A和DHS调节凋亡的方法，以及用于这些方法的反义寡核苷酸和凋亡特异性eIF-5A和DHS的表达载体。
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5.发明申请Use of antisense oligonucleotides or siRNA to suppress expression of eIF-5A1 失效使用反义寡核苷酸或siRNA抑制eIF-5A1的表达公开(公告)号：US20060178330A1
公开(公告)日：2006-08-10
申请号：US11287460
申请日：2005-11-28
申请人： John Thompson , Bruce Galton , Catherine Taylor , Adrienne Boone , Elizabeth Helkkila , Dominic Cliche , Shelley Culp-Stewart , John Flanagan , Michelle Senchyna
发明人： John Thompson , Bruce Galton , Catherine Taylor , Adrienne Boone , Elizabeth Helkkila , Dominic Cliche , Shelley Culp-Stewart , John Flanagan , Michelle Senchyna
CPC分类号： C12N15/113 , A61K31/7088 , C12N2310/11 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis factor 5A1 or simply factor 5A1, apoptosis factor 5A1 nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of factor 5A1. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines by inhibiting expression of apoptosis factor 5A.
摘要翻译： 本发明涉及凋亡特异性真核起始因子5A（eIF-5A），称为凋亡因子5A1或简单因子5A1，凋亡因子5A1核酸和多肽，以及使用反义核苷酸或siRNA至少抑制或抑制细胞凋亡的方法 抑制因子5A1的表达。 本发明还涉及通过抑制凋亡因子5A的表达抑制或抑制促炎细胞因子的表达。
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6.发明申请Use of Antisense Oligonucleotides or siRNA to Suppress Expression of eIF-5A1 审中-公开使用反义寡核苷酸或siRNA抑制eIF-5A1的表达公开(公告)号：US20130066058A1
公开(公告)日：2013-03-14
申请号：US13572123
申请日：2012-08-10
申请人： John E. Thompson , Bruce C. Galton , Catherine Taylor , Adrienne Boone , Elizabeth Margaret Heikkila , Dominic Cliche , Shelley Culp-Stewart , John Gerard Flannagan , Michelle Senchyna
发明人： John E. Thompson , Bruce C. Galton , Catherine Taylor , Adrienne Boone , Elizabeth Margaret Heikkila , Dominic Cliche , Shelley Culp-Stewart , John Gerard Flannagan , Michelle Senchyna
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61K31/7088 , C12N2310/11 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis factor 5A1 or simply factor 5A1, apoptosis factor 5A1 nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of factor 5A1. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines by inhibiting expression of apoptosis factor 5A.
摘要翻译： 本发明涉及凋亡特异性真核起始因子5A（eIF-5A），称为凋亡因子5A1或简单因子5A1，凋亡因子5A1核酸和多肽，以及使用反义核苷酸或siRNA至少抑制或抑制细胞凋亡的方法 抑制因子5A1的表达。 本发明还涉及通过抑制凋亡因子5A的表达抑制或抑制促炎细胞因子的表达。
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公开(公告)号：US08242256B2
公开(公告)日：2012-08-14
申请号：US12640148
申请日：2009-12-17
申请人： John E. Thompson , Bruce C. Galton , Catherine Taylor , Adrienne Boone , Elizabeth Heikkila , Dominic Cliche , Shelley Culp-Stewart , John Gerard Flanagan , Michelle Senchyna
发明人： John E. Thompson , Bruce C. Galton , Catherine Taylor , Adrienne Boone , Elizabeth Heikkila , Dominic Cliche , Shelley Culp-Stewart , John Gerard Flanagan , Michelle Senchyna
IPC分类号： C07H21/04
CPC分类号： C12N15/113 , A61K31/7088 , C12N2310/11 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis factor 5A1 or simply factor 5A1, apoptosis factor 5A1 nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of factor 5A1. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines by inhibiting expression of apoptosis factor 5A.
摘要翻译： 本发明涉及凋亡特异性真核起始因子5A（eIF-5A），称为凋亡因子5A1或简单因子5A1，凋亡因子5A1核酸和多肽，以及使用反义核苷酸或siRNA至少抑制或抑制细胞凋亡的方法 抑制因子5A1的表达。 本发明还涉及通过抑制凋亡因子5A的表达抑制或抑制促炎细胞因子的表达。
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8.发明授权Use of antisense oligonucleotides or siRNA to suppress expression of eIF-5A1 失效使用反义寡核苷酸或siRNA抑制eIF-5A1的表达公开(公告)号：US07662796B2
公开(公告)日：2010-02-16
申请号：US11287460
申请日：2005-11-28
申请人： John E. Thompson , Bruce C. Galton , Catherine Taylor , Adrienne Boone , Elizabeth Heikkila , Dominic Cliche , Shelley Culp-Stewart , John Gerard Flanagan , Michelle Senchyna
发明人： John E. Thompson , Bruce C. Galton , Catherine Taylor , Adrienne Boone , Elizabeth Heikkila , Dominic Cliche , Shelley Culp-Stewart , John Gerard Flanagan , Michelle Senchyna
CPC分类号： C12N15/113 , A61K31/7088 , C12N2310/11 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis factor 5A1 or simply factor 5A1, apoptosis factor 5A1 nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of factor 5A1. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines by inhibiting expression of apoptosis factor 5A.
摘要翻译： 本发明涉及凋亡特异性真核起始因子5A（eIF-5A），称为凋亡因子5A1或简单因子5A1，凋亡因子5A1核酸和多肽，以及使用反义核苷酸或siRNA至少抑制或抑制细胞凋亡的方法 抑制因子5A1的表达。 本发明还涉及通过抑制凋亡因子5A的表达抑制或抑制促炎细胞因子的表达。
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公开(公告)号：US07217517B2
公开(公告)日：2007-05-15
申请号：US10277969
申请日：2002-10-23
申请人： John E. Thompson , Catherine Taylor , Dominic Cliche , Charles Dinarello , Leonid Reznikov , Benjamin Pomerantz
发明人： John E. Thompson , Catherine Taylor , Dominic Cliche , Charles Dinarello , Leonid Reznikov , Benjamin Pomerantz
CPC分类号： C07K14/4747 , C12Q1/6883 , C12Q2600/158
摘要： The present invention provides methods of identifying an incidence of ischemia in mammalian tissue, particularly mammalian heart tissue. Further, a method of reducing apoptosis in mammalian tissue, preferably heart tissue, is provided. These methods involve measuring and comparing the gene expression levels of both apoptosis-specific eIF-5A and proliferating eIF-5A and correlating an incidence of ischemia when the expression level of apoptosis-specific eIF-5a is higher than proliferating eIF-5A. In the method of reducing apoptosis in mammalian tissue, there is provided an agent that inhibits expression of apoptosis-specific eIF-5A. Preferred agents are antisense oligonucleotides to human apoptosis-specific eIF-5A.
摘要翻译： 本发明提供了确定哺乳动物组织，特别是哺乳动物心脏组织中缺血发生率的方法。 此外，提供了减少哺乳动物组织，优选心脏组织中细胞凋亡的方法。 这些方法包括测量和比较凋亡特异性eIF-5A和增殖eIF-5A两者的基因表达水平，并且当凋亡特异性eIF-5a的表达水平高于增殖eIF-5A时，相关缺血发生率。 在减少哺乳动物组织中凋亡的方法中，提供了抑制细胞凋亡特异性eIF-5A表达的药物。 优选的试剂是对人细胞凋亡特异性eIF-5A的反义寡核苷酸。
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公开(公告)号：US20110098460A1
公开(公告)日：2011-04-28
申请号：US12640148
申请日：2009-12-17
申请人： John E. Thompson , Bruce C. Galton , Catherine Taylor , Adrienne Boone , Elizabeth Heikkila , Dominic Cliche , Shelley Culp-Stewart , John Gerard Flanagan , Michelle Senchyna
发明人： John E. Thompson , Bruce C. Galton , Catherine Taylor , Adrienne Boone , Elizabeth Heikkila , Dominic Cliche , Shelley Culp-Stewart , John Gerard Flanagan , Michelle Senchyna
IPC分类号： C07H21/02
CPC分类号： C12N15/113 , A61K31/7088 , C12N2310/11 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis factor 5A1 or simply factor 5A1, apoptosis factor 5A1 nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of factor 5A1. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines by inhibiting expression of apoptosis factor 5A.
摘要翻译： 本发明涉及凋亡特异性真核起始因子5A（eIF-5A），称为凋亡因子5A1或简单因子5A1，凋亡因子5A1核酸和多肽，以及使用反义核苷酸或siRNA至少抑制或抑制细胞凋亡的方法 抑制因子5A1的表达。 本发明还涉及通过抑制凋亡因子5A的表达抑制或抑制促炎细胞因子的表达。
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