公开(公告)号：US20240133794A1

公开(公告)日：2024-04-25

申请号：US18278079

申请日：2022-02-11

申请人： Cellular Highways Ltd

发明人： Alex ZHUKOV

IPC分类号： G01N15/14

CPC分类号： G01N15/1459 ,  G01N2015/1447

摘要： An optical particle analyser is provided; the analyser comprising: a microfluidic chip comprising: a flow channel for carrying particles; the flow channel arranged between a transparent window and a non-transparent substrate; a light source configured to emit an illumination beam towards the flow channel; wherein the microfluidic chip and the light source are arranged such that, in use, the illumination beam impinges the window at an oblique angle of incidence. By providing the optical particle analyser in this manner, high performance particle analysis may be accurately carried out.

公开(公告)号：US20240230510A9

公开(公告)日：2024-07-11

申请号：US18278079

申请日：2022-02-11

申请人： Cellular Highways Ltd

发明人： Alex ZHUKOV

IPC分类号： G01N15/14

CPC分类号： G01N15/1459 ,  G01N2015/1447

摘要： An optical particle analyser is provided; the analyser comprising: a microfluidic chip comprising: a flow channel for carrying particles; the flow channel arranged between a transparent window and a non-transparent substrate; a light source configured to emit an illumination beam towards the flow channel; wherein the microfluidic chip and the light source are arranged such that, in use, the illumination beam impinges the window at an oblique angle of incidence. By providing the optical particle analyser in this manner, high performance particle analysis may be accurately carried out.

公开(公告)号：US20230288315A1

公开(公告)日：2023-09-14

申请号：US18019528

申请日：2021-08-05

申请人： Cellular Highways Ltd.

发明人： Sam HYDE ,  Alex ZHUKOV ,  Robyn PRITCHARD ,  Gang XIONG ,  Samson ROGERS

IPC分类号： G01N15/14

CPC分类号： G01N15/1484 ,  G01N15/1434 ,  G01N2015/1452

摘要： A method of producing a microfluidic chip for use in flow cytometry, the method comprising the steps of providing an opaque substrate, a first surface of which is optically smooth for visible light providing a continuous transparent layer across said first surface by vapour deposition so as to provide conformal contact between the continuous transparent layer and the first surface of the substrate providing a flow channel bounded on a first side by the continuous transparent layer and etching an aperture in a second surface of the substrate extending to the first surface of the substrate so as to provide an optical path between said second surface and the flow channel wherein the continuous transparent layer is less reactive to the etching than the substrate.