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    OPTICAL PARTICLE ANALYSER WITH ILLUMINATION AT AN OBLIQUE ANGLE ONTO A NON-TRANSPARENT MICROFLUIDIC CHIP
    1.
    发明公开
    OPTICAL PARTICLE ANALYSER WITH ILLUMINATION AT AN OBLIQUE ANGLE ONTO A NON-TRANSPARENT MICROFLUIDIC CHIP 审中-公开

    公开(公告)号：US20240133794A1

    公开(公告)日：2024-04-25

    申请号：US18278079

    申请日：2022-02-11

    申请人： Cellular Highways Ltd

    发明人： Alex ZHUKOV

    IPC分类号： G01N15/14

    CPC分类号： G01N15/1459 ,  G01N2015/1447

    摘要： An optical particle analyser is provided; the analyser comprising: a microfluidic chip comprising: a flow channel for carrying particles; the flow channel arranged between a transparent window and a non-transparent substrate; a light source configured to emit an illumination beam towards the flow channel; wherein the microfluidic chip and the light source are arranged such that, in use, the illumination beam impinges the window at an oblique angle of incidence. By providing the optical particle analyser in this manner, high performance particle analysis may be accurately carried out.

    OPTICAL PARTICLE ANALYSER WITH ILLUMINATION AT AN OBLIQUE ANGLE ONTO A NON-TRANSPARENT MICROFLUIDIC CHIP
    2.
    发明公开
    OPTICAL PARTICLE ANALYSER WITH ILLUMINATION AT AN OBLIQUE ANGLE ONTO A NON-TRANSPARENT MICROFLUIDIC CHIP 审中-公开

    公开(公告)号：US20240230510A9

    公开(公告)日：2024-07-11

    申请号：US18278079

    申请日：2022-02-11

    申请人： Cellular Highways Ltd

    发明人： Alex ZHUKOV

    IPC分类号： G01N15/14

    CPC分类号： G01N15/1459 ,  G01N2015/1447

    摘要： An optical particle analyser is provided; the analyser comprising: a microfluidic chip comprising: a flow channel for carrying particles; the flow channel arranged between a transparent window and a non-transparent substrate; a light source configured to emit an illumination beam towards the flow channel; wherein the microfluidic chip and the light source are arranged such that, in use, the illumination beam impinges the window at an oblique angle of incidence. By providing the optical particle analyser in this manner, high performance particle analysis may be accurately carried out.

    PARTICLE STANDARDS FOR REFLECTED LIGHT SCATTER MEASUREMENTS FROM DEGENERATE PARTICLE FOCI
    3.
    发明申请
    PARTICLE STANDARDS FOR REFLECTED LIGHT SCATTER MEASUREMENTS FROM DEGENERATE PARTICLE FOCI 有权

    公开(公告)号：US20220057316A1

    公开(公告)日：2022-02-24

    申请号：US17401370

    申请日：2021-08-13

    申请人： Cellular Highways Ltd.

    发明人： Alexander ZHUKOV

    IPC分类号： G01N15/10 ,  G01N15/02 ,  G01N15/14

    摘要： A method of selecting a type of particle for use in standardisation and/or calibration of a flow cytometer. The method includes determining the location of two or more particle focal points of particles flowing through a cross section of a channel in the flow cytometer; for each type of particle, determining for each particle focal point, for a beam of light directed at a type of particle at said particle focal point from a first direction, the total intensity of light scattered along a second direction; determining the difference between the highest and lowest determined light intensities of the light intensities determined at the two or more particle focal points; and selecting a type of particle for which the difference between the highest and lowest determined light intensities at the two or more particle focal points is below a predetermined threshold.

    APPARATUS FOR TRANSMISSION OPTICAL MEASUREMENTS WITH A WINDOW IN AN OPAQUE SUBSTRATE
    5.
    发明公开
    APPARATUS FOR TRANSMISSION OPTICAL MEASUREMENTS WITH A WINDOW IN AN OPAQUE SUBSTRATE 审中-公开

    公开(公告)号：US20230288315A1

    公开(公告)日：2023-09-14

    申请号：US18019528

    申请日：2021-08-05

    申请人： Cellular Highways Ltd.

    发明人： Sam HYDE ,  Alex ZHUKOV ,  Robyn PRITCHARD ,  Gang XIONG ,  Samson ROGERS

    IPC分类号： G01N15/14

    CPC分类号： G01N15/1484 ,  G01N15/1434 ,  G01N2015/1452

    摘要： A method of producing a microfluidic chip for use in flow cytometry, the method comprising the steps of providing an opaque substrate, a first surface of which is optically smooth for visible light providing a continuous transparent layer across said first surface by vapour deposition so as to provide conformal contact between the continuous transparent layer and the first surface of the substrate providing a flow channel bounded on a first side by the continuous transparent layer and etching an aperture in a second surface of the substrate extending to the first surface of the substrate so as to provide an optical path between said second surface and the flow channel wherein the continuous transparent layer is less reactive to the etching than the substrate.

    Particle standards for reflected light scatter measurements from degenerate particle foci
    8.
    发明授权
    Particle standards for reflected light scatter measurements from degenerate particle foci 有权

    公开(公告)号：US12000769B2

    公开(公告)日：2024-06-04

    申请号：US17401370

    申请日：2021-08-13

    申请人： Cellular Highways Ltd.

    发明人： Alexander Zhukov

    IPC分类号： G01N15/10 ,  G01N15/0205 ,  G01N15/14 ,  G01N15/1434

    CPC分类号： G01N15/1012 ,  G01N15/0205 ,  G01N15/1425 ,  G01N15/1434 ,  G01N2015/0238

    摘要： A method of selecting a type of particle for use in standardisation and/or calibration of a flow cytometer. The method includes determining the location of two or more particle focal points of particles flowing through a cross section of a channel in the flow cytometer; for each type of particle, determining for each particle focal point, for a beam of light directed at a type of particle at said particle focal point from a first direction, the total intensity of light scattered along a second direction; determining the difference between the highest and lowest determined light intensities of the light intensities determined at the two or more particle focal points; and selecting a type of particle for which the difference between the highest and lowest determined light intensities at the two or more particle focal points is below a predetermined threshold.