公开(公告)号：US11104952B2

公开(公告)日：2021-08-31

申请号：US15574037

申请日：2015-11-19

Applicant: Centre for Addiction and Mental Health

Inventor： Clement C. Zai ,  James L. Kennedy

IPC: G01N33/48 ,  C12Q1/6883 ,  G16B30/00 ,  G16B20/00 ,  G16B99/00

Abstract: The invention provides genetic markers of severe suicidal behavior, related compositions, computer systems, and methods.

公开(公告)号：US10662475B2

公开(公告)日：2020-05-26

申请号：US15122101

申请日：2015-02-27

Applicant: Centre for Addiction and Mental Health

Inventor： Arun K. Tiwari ,  Eva J. Brandl ,  Nabilah I. Chowdhury ,  Vanessa F. Gonçalves ,  Jennie G. Pouget ,  James L. Kennedy ,  Daniel J. Mueller ,  Clement C. Zai

IPC: C12Q1/68 ,  C12Q1/6883 ,  G16B20/00 ,  G01N33/50

Abstract: The invention provides methods and compositions for the treatment of a subject having a psychiatric disease or disorder based upon the subject's genotype and/or the number of risk alleles carried by the subject, which risk alleles have been found by the present inventors to predispose a subject to antipsychotic medication induced weight gain (AIWG). The methods of the invention also provide for different treatments, or different treatment regimens, for the subject depending on the subject's risk of AIWG. Related compositions, in the form of kits, systems, and computer-readable media are also provided.

公开(公告)号：US10301678B2

公开(公告)日：2019-05-28

申请号：US15029955

申请日：2014-10-17

Applicant: Centre for Addiction and Mental Health

Inventor： Clement C. Zai ,  James L. Kennedy ,  Daniel J. Mueller

IPC: C12Q1/68 ,  C12Q1/6883 ,  A61K31/5513

Abstract: Provided is a method of predicting a subject's weight response to antipsychotic drug treatment by obtaining a biological sample comprising genomic DNA from the subject and determining the presence or absence of one or more polymorphisms in the GABRA2 gene of the subject, wherein the presence of said one or more polymorphisms is predictive of the subject's weight change in response to antipsychotic drug treatment. The method also may comprise additional steps including treating the subject. Kits and components thereof are also provided.

公开(公告)号：US10435748B2

公开(公告)日：2019-10-08

申请号：US15107437

申请日：2014-12-23

Applicant: Centre for Addiction and Mental Health

Inventor： Clement C. Zai ,  James L. Kennedy

IPC: G06F19/00 ,  C12Q1/6883 ,  G16B30/00 ,  G16H50/30 ,  G16C99/00

Abstract: Provided are polymorphic markers defined by SEQ ID Nos:1-5 which are associated with suicide risk. Also provided are methods of use of such markers as well as kits for identifying the presence of markers.

公开(公告)号：US20180355431A1

公开(公告)日：2018-12-13

申请号：US15574037

申请日：2015-11-19

Applicant: Centre for Addiction and Mental Health

Inventor： Clement C. Zai ,  James L. Kennedy

IPC: C12Q1/6883 ,  G06F19/22

CPC classification number: C12Q1/6883 ,  C12Q2600/156 ,  G01N2800/30 ,  G06F19/10 ,  G06F19/18 ,  G06F19/22

Abstract: The invention provides genetic markers of severe suicidal behavior, related compositions, computer systems, and methods.

公开(公告)号：US20170073755A1

公开(公告)日：2017-03-16

申请号：US15122101

申请日：2015-02-27

Applicant: Centre For Addiction and Mental Health

Inventor： Arun K Tiwari ,  Eva J. Brand ,  Nabilah I. Chowdhury ,  Vanessa F. Gonçalves ,  Jennie G. Pouget ,  James L. Kennedy ,  Daniel J. Mueller ,  Clement C. Zai

IPC: C12Q1/68 ,  A61K31/519 ,  G06F19/18 ,  A61K31/445

Abstract: The invention provides methods and compositions for the treatment of a subject having a psychiatric disease or dis order based upon the subject's genotype and/or the number of risk alleles carried by the subject, which risk alleles have been found by the present inventors to predispose a subject to antipsychotic medication induced weight gain (AIWG). The methods of the inven tion also provide for different treatments, or different treatment regimens, for the subject depending on the subject's risk of AIWG. Related compositions, in the form of kits, systems, and computer-readable media are also provided.

Abstract translation: 本发明提供了用于治疗患有基于受试者的基因型和/或受试者携带的风险等位基因数目的精神疾病或疾病顺序的受试者的方法和组合物，本发明人发现风险等位基因易于使用 服用抗精神病药物引起的体重增加（AIWG）。 本方法还根据受试者的AIWG风险，为受试者提供不同的治疗方案或不同的治疗方案。 还提供了试剂盒，系统和计算机可读介质形式的相关组合物。

公开(公告)号：US20170002412A1

公开(公告)日：2017-01-05

申请号：US15107437

申请日：2014-12-23

Applicant: CENTRE FOR ADDICTION AND MENTAL HEALTH

Inventor： Clement C. Zai ,  James L. Kennedy

IPC: C12Q1/68 ,  G06F19/00 ,  G06F19/22

CPC classification number: C12Q1/6883 ,  C12Q2600/156 ,  G16B30/00 ,  G16C99/00 ,  G16H50/30 ,  Y02A90/26

Abstract: Provided are polymorphic markers defined by SEQ ID Nos:1-5 which are associated with suicide risk. Also provided are methods of use of such markers as well as kits for identifying the presence of markers.

Abstract translation: 提供了与自杀风险相关的SEQ ID NO：1-5定义的多态性标记。 还提供了使用这种标记物的方法以及用于鉴定标记物存在的试剂盒。

公开(公告)号：US20160237499A1

公开(公告)日：2016-08-18

申请号：US15029955

申请日：2014-10-17

Applicant: CENTRE FOR ADDICTION AND MENTAL HEALTH

Inventor： Clement C. Zai ,  James L. Kennedy ,  Daniel J. Mueller

IPC: C12Q1/68 ,  A61K31/5513

CPC classification number: C12Q1/6883 ,  A61K31/5513 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158

Abstract: Provided is a method of predicting a subject's weight response to antipsychotic drug treatment by obtaining a biological sample comprising genomic DNA from the subject and determining the presence or absence of one or more polymorphisms in the GABRA2 gene of the subject, wherein the presence of said one or more polymorphisms is predictive of the subject's weight change in response to antipsychotic drug treatment. The method also may comprise additional steps including treating the subject. Kits and components thereof are also provided.

Abstract translation: 提供了一种通过获得包含来自受试者的基因组DNA的生物学样品并确定受试者的GABRA2基因中存在或不存在一种或多种多态性的方法来预测受试者对抗精神病药物治疗的重量反应的方法，其中所述一种 或更多的多态性是预测受试者响应于抗精神病药物治疗的体重变化。 该方法还可以包括另外的步骤，包括治疗受试者。 还提供了套件及其部件。