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公开(公告)号：US20240285603A1
公开(公告)日：2024-08-29
申请号：US18394252
申请日：2023-12-22
IPC分类号： A61K31/4545 , A61K9/00 , A61P23/00
CPC分类号： A61K31/4545 , A61K9/0019 , A61P23/00
摘要： The invention provides compositions and methods for intrathecal administration of the compound MCOPPB or a pharmaceutically acceptable salt thereof for treating pain, such as neuropathic pain suffered by an adult human.
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公开(公告)号：US11820727B1
公开(公告)日：2023-11-21
申请号：US17852693
申请日：2022-06-29
发明人： James N. Campbell , Scott M. Duncan
IPC分类号： C07C233/20 , C07D401/02 , A61K45/06
CPC分类号： C07C233/20 , C07D401/02 , A61K45/06 , C07C2601/14
摘要： The invention provides capsaicinoid prodrug compounds, pharmaceutical compositions, and their use in the treatment of medical conditions, such as pain, and in agonizing TRPV1 activity.
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公开(公告)号：US11447444B1
公开(公告)日：2022-09-20
申请号：US16745636
申请日：2020-01-17
发明人： James N. Campbell , Scott M. Duncan
IPC分类号： C07C233/20 , C07D401/02 , A61K45/06
摘要： The invention provides capsaicinoid prodrug compounds, pharmaceutical compositions, and their use in the treatment of medical conditions, such as pain, and in agonizing TRPV1 activity.
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公开(公告)号：US20190022036A1
公开(公告)日：2019-01-24
申请号：US16070889
申请日：2017-01-20
IPC分类号： A61K31/165 , A61P29/02 , A61K47/10 , A61K9/00
摘要： A method of ameliorating pain for a duration of at least 3 months due to an intermetatarsal neuroma in a patient, comprising administering by injection into or adjacent to the patient's intermetatarsal space having an intermetatarsal neuroma at least a first dose of capsaicin and a second dose of capsaicin, no sooner than one month after the first dose, to ameliorate pain due to the intermetatarsal neuroma.
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公开(公告)号：US11045459B1
公开(公告)日：2021-06-29
申请号：US16589218
申请日：2019-10-01
IPC分类号： A61K31/4545 , A61P23/00 , A61K9/00
摘要： The invention provides compositions and methods for intrathecal administration of the compound MCOPPB or a pharmaceutically acceptable salt thereof for treating pain, such as neuropathic pain suffered by an adult human.
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公开(公告)号：US11026903B2
公开(公告)日：2021-06-08
申请号：US16984384
申请日：2020-08-04
摘要： The invention provides methods and compositions for treatment of pain, such as joint pain, using capsaicin in a procedure that attenuates transient burning sensation experienced by patients due to capsaicin administration. The methods desirably provide relief from joint pain, such as osteoarthritic knee joint pain, for an extended duration, such as at least about 3 months, 6 months, 9 months, or 1 year. To attenuate the adverse side effect of a transient burning sensation caused by capsaicin-induced neuronal excitation, the methods utilize a cooling article, such as a material wrap cooled via a circulating fluid, to reduce the temperature of tissue to be exposed to capsaicin to within a certain range for certain durations of time, optionally in combination with administering a local anesthetic agent, resulting in the substantial reduction or even elimination of transient burning sensation caused by capsaicin.
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公开(公告)号：US20210145772A1
公开(公告)日：2021-05-20
申请号：US16937810
申请日：2020-07-24
发明人： James N. Campbell , Peter D. Hanson
IPC分类号： A61K31/165 , A61P17/00 , A61K9/00
摘要： The invention provides methods for treating acral lick granuloma in a canine using a capsaicinoid, such as capsaicin. The invention also provides methods for deactivating a nerve fiber selected from the group consisting of a C-fiber and an A-delta fiber, each being located in or proximal to an acral lick granuloma in a canine, using a capsaicinoid, such as capsaicin.
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公开(公告)号：US20210386728A1
公开(公告)日：2021-12-16
申请号：US17327888
申请日：2021-05-24
IPC分类号： A61K31/4545 , A61P23/00 , A61K9/00
摘要： The invention provides compositions and methods for intrathecal administration of the compound MCOPPB or a pharmaceutically acceptable salt thereof for treating pain, such as neuropathic pain suffered by an adult human.
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公开(公告)号：US20210299072A1
公开(公告)日：2021-09-30
申请号：US17339414
申请日：2021-06-04
IPC分类号： A61K31/167 , A61P19/02 , A61F7/10 , A61K9/00
摘要： The invention provides methods and compositions for treatment of pain, such as joint pain, using capsaicin in a procedure that attenuates transient burning sensation experienced by patients due to capsaicin administration. The methods desirably provide relief from joint pain, such as osteoarthritic knee joint pain, for an extended duration, such as at least about 3 months, 6 months, 9 months, or 1 year. To attenuate the adverse side effect of a transient burning sensation caused by capsaicin-induced neuronal excitation, the methods utilize a cooling article, such as a material wrap cooled via a circulating fluid, to reduce the temperature of tissue to be exposed to capsaicin to within a certain range for certain durations of time, optionally in combination with administering a local anesthetic agent, resulting in the substantial reduction or even elimination of transient burning sensation caused by capsaicin.
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公开(公告)号：US20200338064A1
公开(公告)日：2020-10-29
申请号：US16774490
申请日：2020-01-28
IPC分类号： A61K31/47 , A61K31/167 , A61K31/445 , A61K47/44 , A61K47/14 , A61K47/26 , A61K47/10 , A61K9/00 , A61K31/24 , A61K31/245
摘要： A transdermal topical anesthetic formulation, which can be used to ameliorate or inhibit neuropathic pain, has been developed. In the preferred embodiment, the topical anesthetic is a local anesthetic such as lidocaine, most preferably lidocaine free-base in a gel, and the dosage of the local anesthetic is effective in the painful area or immediately adjacent areas, to ameliorate or eliminate the pain. High concentration of local anesthetic in solution in the carrier is used to drive rapid release and uptake of the drug. Relief is typically obtained for a period of several hours.
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