公开(公告)号：US20190316132A1

公开(公告)日：2019-10-17

申请号：US16305858

申请日：2017-06-06

申请人： Cepheid

发明人： Sergey G. Lokhov ,  Alexander A. Gall ,  Vera Baraznenok ,  Ekaterina V. Viazovkina ,  Irina Shishkina ,  David H. Persing

IPC分类号： C12N15/115 ,  C12Q1/6853 ,  C12Q1/686

摘要： The present disclosure relates to aptamers for temperature-dependent reversible inhibition of thermostable polymerase activity in order to improve sensitivity and specificity of various reactions and assays involving hot start polynucleotide synthesis. Methods for use of the aptamers and related compositions and kits are also provided.

公开(公告)号：US11299739B2

公开(公告)日：2022-04-12

申请号：US16305858

申请日：2017-06-06

申请人： Cepheid

发明人： Sergey G. Lokhov ,  Alexander A. Gall ,  Vera Baraznenok ,  Ekaterina V. Viazovkina ,  Irina Shishkina ,  David H. Persing

IPC分类号： C12Q1/6853 ,  C12Q1/686 ,  C12N15/115

摘要： The present disclosure relates to aptamers for temperature-dependent reversible inhibition of thermostable polymerase activity in order to improve sensitivity and specificity of various reactions and assays involving hot start polynucleotide synthesis. Methods for use of the aptamers and related compositions and kits are also provided.

公开(公告)号：US20220389427A1

公开(公告)日：2022-12-08

申请号：US17687473

申请日：2022-03-04

申请人： Cepheid

发明人： Sergey G. Lokhov ,  Alexander A. Gall ,  Vera Baraznenok ,  Ekaterina V. Viazovkina ,  Irina Shishkina ,  David H. Persing

IPC分类号： C12N15/115 ,  C12Q1/6853 ,  C12Q1/686

摘要： The present disclosure relates to aptamers for temperature-dependent reversible inhibition of thermostable polymerase activity in order to improve sensitivity and specificity of various reactions and assays involving hot start polynucleotide synthesis. Methods for use of the aptamers and related compositions and kits are also provided.