摘要:
The present invention relates to a recombinant adenovirus capable of regulating angiogenesis, which comprises (a) an adenoviral ITR (inverted terminal repeat) nucleotide sequence; and (b) a transcription regulatory sequence for a VEGF-A (vascular endothelial growth factor-A) gene comprising (i) a nucleotide sequence encoding a DNA binding domain comprising a zinc finger domain to bind to a site in a VEGF-A promoter sequence as set forth in nucleotides 1-2362 of SEQ ID NO:1, and (ii) a transcription activation domain or a transcription inhibitory domain linked to the nucleotide sequence encoding the DNA binding domain; and a pharmaceutical composition comprising the recombinant adenovirus.
摘要翻译:本发明涉及能够调节血管生成的重组腺病毒,其包含(a)腺病毒ITR(反向末端重复)核苷酸序列; (b)VEGF-A(血管内皮生长因子-A)基因的转录调控序列,其包含(i)编码包含锌指结构域的DNA结合域的核苷酸序列以结合VEGF-A启动子中的位点 序列,如SEQ ID NO:1的核苷酸1-2362所示,和(ii)与编码DNA结合结构域的核苷酸序列连接的转录活化结构域或转录抑制结构域; 和包含重组腺病毒的药物组合物。
摘要:
The present invention relates to a recombinant adenovirus capable of regulating angiogenesis, which comprises (a) an adenoviral UR (inverted terminal repeat) nucleotide sequence; and (b) a transcription regulatory sequence for a VEGF-A (vascular endothelial growth factor-A) gene comprising (i) a nucleotide sequence encoding a DNA binding domain comprising a zinc finger domain to bind to a site in a VEGF-A promoter sequence as set forth in nucleotides 1-2362 of SEQ ID NO:1, and (ii) a transcription activation domain or a transcription inhibitory domain linked to the nucleotide sequence encoding the DNA binding domain; and a pharmaceutical composition comprising the recombinant adenovirus.
摘要:
An anisotropic texture filtering method using area coverage weight of sub-texel precision includes the steps of executing filtering by applying weights to texels; representing four sides of the footprint by four linear equations for computing area coverage weight; obtaining sub-texel masks from a table by addresses given by values of line equations; and calculating the final area coverage weight with four sub-texel masks obtained in the previous step.
摘要:
Disclosed are a method and system for proposing an advertisement keyword. The method includes receiving an input of a keyword associated with a new advertiser, extracting a representative keyword from among advertisement keywords of an existing advertiser having an outcome of a prescribed reference value or more, comparing a keyword inputted in association with the new advertiser and the representative keyword of the existing advertiser, determining whether the new advertiser has the same business category as that of the existing advertiser based on the compared result, designating a predetermined keyword-set as a business category keyword based on the determined result, and proposing the advertisement keyword to the new advertiser based on a result obtained by analyzing the business category keyword.
摘要:
A signal recording apparatus for a video instrument using a magnetic recording medium which is capable of more accurately computing the signal to be recorded on the tape by correcting the output signal when affixing "1" or "0" after computing the output signal to which the pilot tone is affixed. In addition, one line block is used on the assumption that "1" or "0" is always affixed to the code word.