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    Compounds for modulating cell proliferation
    5.
    发明授权
    Compounds for modulating cell proliferation 有权
    用于调节细胞增殖的化合物

    公开(公告)号：US07563820B2

    公开(公告)日：2009-07-21

    申请号：US10501699

    申请日：2003-01-17

    申请人： Chaim M. Roifman ,  Peter Demin ,  Thomas Grunberger ,  Olga Rounova ,  Octavian Laurand Cimpean

    发明人： Chaim M. Roifman ,  Peter Demin ,  Thomas Grunberger ,  Olga Rounova ,  Octavian Laurand Cimpean

    IPC分类号： C07C255/03 ,  A61K31/275

    CPC分类号： C07C255/41 ,  C07C317/46 ,  C07D213/71

    摘要： The following compounds of formulae (I) and (III) which may be useful in treating a variety of cell proliferative disorders are disclosed: Formula (I), (II), wherein R1, R2 and R3 are each independently selected from H, OH, C1-6alkyl, C1-6alkoxy, NH2, NH—C1-6alkyl, N(C1-6alkyl), SH, S—C1-6alkyl, NO2, CF3, OCF3 and halo; R4 is unsubstituted Ar, or Ar substituted with 1-4 substituents, independently selected from C1-6alkyl, C1-6alkoxy and halo; X is selected from (CH2CH2O)n and (CH2)n, and n=1-4.

    摘要翻译： 公开了可用于治疗各种细胞增殖性疾病的以下式（I）和（III）化合物：式（I），（II）其中R 1，R 2和R 3各自独立地选自H，OH ，C 1-6烷基，C 1-6烷氧基，NH 2，NH-C 1-6烷基，N（C 1-6烷基），SH，S-C 1-6烷基，NO 2，CF 3，OCF 3和卤素; R4是未取代的Ar或被1-4个取代基取代的Ar，其独立地选自C 1-6烷基，C 1-6烷氧基和卤素; X选自（CH 2 CH 2 O）n和（CH 2）n，n = 1-4。

    Compounds for modulating cell proliferation
    7.
    发明申请
    Compounds for modulating cell proliferation 审中-公开
    用于调节细胞增殖的化合物

    公开(公告)号：US20070197660A1

    公开(公告)日：2007-08-23

    申请号：US10566815

    申请日：2004-07-30

    申请人： Chaim Roifman ,  Peter Demin ,  Olga Rounova ,  Thomas Grunberger ,  Octavian Cimpean

    发明人： Chaim Roifman ,  Peter Demin ,  Olga Rounova ,  Thomas Grunberger ,  Octavian Cimpean

    IPC分类号： A61K31/135

    CPC分类号： A61K31/4402 ,  C07C255/41 ,  C07C323/46 ,  C07D213/71

    摘要： Compounds having the Formula (I) or (III) wherein R1, R2 and R3 are each independently selected from H, OH, C1-6alkyl, C1-6alkoxy, NH2, NH—(C1-6alkyl), N(C1-6alkyl)(C1-6alkyl), SH, S—C1-6alkyl, NO2, CF3, OCF3, and halo; R4 is unsubstituted Ar or Ar substituted with 1-4 substituents independently selected from C1-6alkyl, C1-6alkoxy and halo; X is selected from (CH2CH2O)n and (CH)n, and n=1-4, salts, solvates and hydrates thereof, useful for modulating or inhibiting cell proliferation, are described.

    摘要翻译： 具有式（I）或（III）的化合物，其中R 1，R 2和R 3各自独立地选自H，OH， C 1-6烷基，C 1-6烷氧基，NH 2，NH-（C 1-6）烷基， 烷基），N（C 1-6烷基）（C 1-6烷基），SH，SC 1-6烷基， CH 2，CF 3，OCF 3 N和卤素; R 4是未取代的Ar或Ar，其被1-4个独立地选自C 1-6 - 烷基，C 1-6 - 烷氧基和卤代 ; X选自（CH 2 CH 2 CH 2）n和（CH）n N，且n = 1 -4，其盐，溶剂化物和水合物，可用于调节或抑制细胞增殖。

    Compounds useful for modulating abnormal cell proliferation
    9.
    发明授权
    Compounds useful for modulating abnormal cell proliferation 有权
    可用于调节异常细胞增殖的化合物

    公开(公告)号：US07202383B2

    公开(公告)日：2007-04-10

    申请号：US10940010

    申请日：2004-09-14

    申请人： Chaim Roifman ,  Peter Demin ,  Olga Rounova ,  Tom Grunberger

    发明人： Chaim Roifman ,  Peter Demin ,  Olga Rounova ,  Tom Grunberger

    IPC分类号： C07C233/09 ,  A61K31/165

    CPC分类号： C07C235/34

    摘要： There is described compounds of Formula I, and salts, solvates and hydrates thereof: wherein: R1, R2 and R3 are each independently selected from OH, C1-6alkyl, OC1-6alkyl, OC(O)C1-6alkyl, C(O)OC1-6alkyl, NH2, NH—C1-6alkyl, N(C1-6alkyl)(C1-6alkyl), C(O)NHC1-6alkyl, C(O)N(C1-6alkyl)(C1-6alkyl), SH, SC1-6alkyl, NO2, CF3, OCF3 and halogen; and Ar is an aromatic or heteroaromatic group chosen from benzene, naphthalene, quinoline, isoquinoline, indole, pyridine, pyrasine, pyrimidine, imidazole, furan and thiophene, unsubstituted or substituted with 1–4 substituents independently selected from OH, C1-6alkyl, C1-6alkoxy, C1-3alkylenedioxy, NH2, NH—C1-6alkyl, N(C1-6alkyl)(C1-6)(C1-6alkyl), SH, S—C1-6alkyl, NO2, CF3, OCF3 and halogen. The compounds of Formula I are useful: in therapeutic methods and compositions for modulating cell proliferation, in diagnostic assays and as research tools.

    摘要翻译： 描述了式I的化合物及其盐，溶剂化物和水合物：