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7 条记录 (耗时 0.031 秒)

    Interferon-α (IFN-α) fused proteins comprising IFN-α and a cytoplasmic transduction peptide (CTP)
    1.
    发明授权
    Interferon-α (IFN-α) fused proteins comprising IFN-α and a cytoplasmic transduction peptide (CTP) 有权
    包含IFN-α和细胞质转导肽（CTP）的干扰素-α（IFN-α）融合蛋白

    公开(公告)号：US08623348B2

    公开(公告)日：2014-01-07

    申请号：US13260490

    申请日：2009-03-27

    申请人： Chan Kyu Lee ,  Seonyoung Yang ,  Eun Ju Kang ,  Kang Ryu ,  Hyun Soo Lee ,  Yong Soo Bae

    发明人： Chan Kyu Lee ,  Seonyoung Yang ,  Eun Ju Kang ,  Kang Ryu ,  Hyun Soo Lee ,  Yong Soo Bae

    IPC分类号： A61K38/21 ,  A61K39/00 ,  A61K39/385 ,  C07K14/56 ,  C12P21/04

    CPC分类号： C07K14/56 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/10

    摘要： Disclosed is an interferon-α (IFN-α) fused protein having IFN-α fused to a cytoplasmic transduction peptide (CTP). The disclosure relates to a fused protein wherein a CTP, which binds well to cell-membrane barriers and enables translocation into the liver, is genetically fused to a human IFN-α, thereby enhancing the conjugation capacity of cell membranes and antiviral activity, inhibiting CTP transport into the cell nucleus, and enhancing the translocation and settlement of the fused protein into the liver and of transduction to the liver tissue. Accordingly, it is possible to develop protein-based medicines effective for preventing or treating various liver diseases associated with viral infection at low doses.

    摘要翻译： 公开了具有与细胞质转导肽（CTP）融合的IFN-α的干扰素-α（IFN-α）融合蛋白。 本公开涉及融合蛋白，其中与细胞膜屏障良好结合并能够转运到肝脏中的CTP与人IFN-α遗传融合，从而增强细胞膜的共轭能力和抗病毒活性，抑制CTP 运输到细胞核，并增强融合蛋白的转运和沉降进入肝脏和向肝组织转导。 因此，可以开发有效预防或治疗与低剂量病毒感染相关的各种肝脏疾病的蛋白质类药物。

    Electrolyte of high temperature property and overcharge-prevention property and secondary battery employed with the same
    4.
    发明授权
    Electrolyte of high temperature property and overcharge-prevention property and secondary battery employed with the same 有权
    具有高温性和过充电特性的电解液以及与此相同的二次电池

    公开(公告)号：US08632919B2

    公开(公告)日：2014-01-21

    申请号：US12445601

    申请日：2007-09-21

    申请人： Eun Ju Kang ,  Kyoung-won Kang ,  Hyang Mok Lee ,  Jung Kyu Woo

    发明人： Eun Ju Kang ,  Kyoung-won Kang ,  Hyang Mok Lee ,  Jung Kyu Woo

    IPC分类号： H01M6/16

    CPC分类号： H01M10/0567 ,  H01M10/0569 ,  H01M2300/0025

    摘要： Provided is a secondary battery electrolyte having improved high temperature properties and overcharge-prevention properties, particularly improved overcharge-prevention properties under high voltage/high current conditions, in conjunction with a minimized deterioration of the battery performance, by adding 3 to 5% by weight of cyclohexyl benzene (CHB) and 0.2 to 1.5% by weight of 2-fluoro biphenyl (2-FBP) as overcharge-preventing additives to an electrolyte of a lithium secondary battery.

    摘要翻译： 本发明提供一种具有改善的高温性能和过充电防止性能的二次电池电解质，特别是在高电压/高电流条件下，特别是改进的过充电防止性能，同时最小化电池性能的劣化，通过加入3至5重量％ 的环己基苯（CHB）和0.2〜1.5重量％的作为过充电防止添加剂的2-氟联苯（2-FBP）的锂二次电池的电解质。

    Electrochemical device with high safety at over-voltage and high temperature
    7.
    发明授权
    Electrochemical device with high safety at over-voltage and high temperature 有权
    具有高电压，高温安全性的电化学装置

    公开(公告)号：US07833648B2

    公开(公告)日：2010-11-16

    申请号：US11829226

    申请日：2007-07-27

    申请人： Young Sun Park ,  Myoung Hun Lee ,  Pil Kyu Park ,  Eun Ju Kang ,  Gi Cheul Kim

    发明人： Young Sun Park ,  Myoung Hun Lee ,  Pil Kyu Park ,  Eun Ju Kang ,  Gi Cheul Kim

    IPC分类号： H01M10/42

    CPC分类号： H01M2/34 ,  H01M2/1264 ,  H01M2/1282 ,  H01M2/345 ,  H01M2/348 ,  H01M10/052 ,  H01M10/4235 ,  H01M2200/00 ,  H01M2200/10 ,  Y10T428/2998

    摘要： Disclosed is an electrochemical device including a gas discharge member disposed in inner volumes thereof or used as an element for forming the device, wherein the gas discharge member comprises: (a) a core portion containing a compound that discharges gases other than oxygen at a predetermined temperature range; and (b) a polymeric shell portion for encapsulating the compound and surrounding the core portion. A center pin for an electrochemical device having the gas discharge member inserted into the interstitial volumes of the device is also disclosed. The electrochemical device comprising the gas discharge member, which discharges a large amount of gas at a predetermined temperature and is inserted into the inner volumes of the device, is prevented from ignition or explosion under overcharge and high-temperature storage conditions with no drop in the performance.

    摘要翻译： 公开了一种电化学装置，其包括设置在其内部体积中的气体排出构件或用作用于形成装置的元件，其中气体排出构件包括：（a）芯部，其包含将预定的氧气以外的气体排出的化合物 温度范围; 和（b）用于封装化合物并围绕芯部分的聚合物壳部分。 还公开了一种用于具有插入到装置的间隙体积中的气体放电构件的电化学装置的中心销。 包括气体放电构件的电化学装置在过充电和高温储存条件下防止在预定温度下排放大量气体并插入装置的内部容积中的点火或爆炸，而不会下降 性能。