公开(公告)号：US08623348B2

公开(公告)日：2014-01-07

申请号：US13260490

申请日：2009-03-27

申请人： Chan Kyu Lee ,  Seonyoung Yang ,  Eun Ju Kang ,  Kang Ryu ,  Hyun Soo Lee ,  Yong Soo Bae

发明人： Chan Kyu Lee ,  Seonyoung Yang ,  Eun Ju Kang ,  Kang Ryu ,  Hyun Soo Lee ,  Yong Soo Bae

IPC分类号： A61K38/21 ,  A61K39/00 ,  A61K39/385 ,  C07K14/56 ,  C12P21/04

CPC分类号： C07K14/56 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/10

摘要： Disclosed is an interferon-α (IFN-α) fused protein having IFN-α fused to a cytoplasmic transduction peptide (CTP). The disclosure relates to a fused protein wherein a CTP, which binds well to cell-membrane barriers and enables translocation into the liver, is genetically fused to a human IFN-α, thereby enhancing the conjugation capacity of cell membranes and antiviral activity, inhibiting CTP transport into the cell nucleus, and enhancing the translocation and settlement of the fused protein into the liver and of transduction to the liver tissue. Accordingly, it is possible to develop protein-based medicines effective for preventing or treating various liver diseases associated with viral infection at low doses.

摘要翻译： 公开了具有与细胞质转导肽（CTP）融合的IFN-α的干扰素-α（IFN-α）融合蛋白。 本公开涉及融合蛋白，其中与细胞膜屏障良好结合并能够转运到肝脏中的CTP与人IFN-α遗传融合，从而增强细胞膜的共轭能力和抗病毒活性，抑制CTP 运输到细胞核，并增强融合蛋白的转运和沉降进入肝脏和向肝组织转导。 因此，可以开发有效预防或治疗与低剂量病毒感染相关的各种肝脏疾病的蛋白质类药物。

公开(公告)号：US20120134961A1

公开(公告)日：2012-05-31

申请号：US13260490

申请日：2009-03-27

申请人： Chan Kyu Lee ,  Seonyoung Yang ,  Ju Kang ,  Kang Ryu ,  Hyun Soo Lee ,  Yong Soo Bae

发明人： Chan Kyu Lee ,  Seonyoung Yang ,  Ju Kang ,  Kang Ryu ,  Hyun Soo Lee ,  Yong Soo Bae

IPC分类号： A61K38/21 ,  C12N15/21 ,  C12N15/63 ,  A61P35/00 ,  C12N1/19 ,  C12N5/10 ,  C12P21/00 ,  A61P1/16 ,  C07K14/56 ,  C12N1/21

CPC分类号： C07K14/56 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/10

摘要： Disclosed is an interferon-α (IFN-α) fused protein having IFN-α fused to a cytoplasmic transduction peptide (CTP). The disclosure relates to a fused protein wherein a CTP, which binds well to cell-membrane barriers and enables translocation into the liver, is genetically fused to a human IFN-α, thereby enhancing the conjugation capacity of cell membranes and antiviral activity, inhibiting CTP transport into the cell nucleus, and enhancing the translocation and settlement of the fused protein into the liver and of transduction to the liver tissue. Accordingly, it is possible to develop protein-based medicines effective for preventing or treating various liver diseases associated with viral infection at low doses.

摘要翻译： 公开了具有与细胞质转导肽（CTP）融合的IFN-α的干扰素-α（IFN-α）融合蛋白。 本公开涉及融合蛋白，其中与细胞膜屏障良好结合并能够转运到肝脏中的CTP与人IFN-α遗传融合，从而增强细胞膜的共轭能力和抗病毒活性，抑制CTP 运输到细胞核，并增强融合蛋白的转运和沉降进入肝脏和向肝组织转导。 因此，可以开发有效预防或治疗与低剂量病毒感染相关的各种肝脏疾病的蛋白质类药物。

公开(公告)号：US20110137486A1

公开(公告)日：2011-06-09

申请号：US12788520

申请日：2010-05-27

申请人： Eun Muk Lim ,  Chan Kyu Lee ,  Dae Youn Um ,  Suk Hwan Cho ,  Si Hyoung Lee

发明人： Eun Muk Lim ,  Chan Kyu Lee ,  Dae Youn Um ,  Suk Hwan Cho ,  Si Hyoung Lee

IPC分类号： G06F7/00

CPC分类号： G01S13/931 ,  B60W30/16 ,  G01S7/41 ,  G01S13/52 ,  G01S13/726 ,  G01S2013/9375

摘要： Disclosed herein is a forward vehicle sensing system for a vehicle. The system includes a sensor and a control unit. The sensor monitors conditions of a road ahead of the vehicle. The control unit detects stationary objects placed on edges of the road, calculates an imaginary line from the consecutive stationary objects, and recognize a prior transverse position of a forward vehicle as a current transverse position of the forward vehicle when determining that an absolute value of a transverse position of the forward vehicle detected on the road is greater than an absolute value of a transverse position of the imaginary line. Therefore, the system of the present invention can prevent the forward vehicle from being incorrectly sensed in such a way as to determine the imaginary line from the stationary objects and compare the transverse position of the forward vehicle to that of the imaginary line.

摘要翻译： 本文公开了一种用于车辆的前进车辆感测系统。 该系统包括传感器和控制单元。 传感器监测车辆前方道路的状况。 控制单元检测放置在道路边缘上的静止物体，计算来自连续静止物体的假想线，并且当确定前方车辆的绝对值时，将前方车辆的先前横向位置识别为前方车辆的当前横向位置 在道路上检测到的前方车辆的横向位置大于假想线的横向位置的绝对值。 因此，本发明的系统可以防止前方车辆被错误地感测，从而确定来自静止物体的假想线，并将前方车辆的横向位置与假想线路的横向位置进行比较。

公开(公告)号：US20110257862A1

公开(公告)日：2011-10-20

申请号：US12947353

申请日：2010-11-16

申请人： Chan Kyu Lee ,  Dae Youn Um ,  Eun Muk Lim ,  Suk Hwan Cho ,  Si Hyoung Lee

发明人： Chan Kyu Lee ,  Dae Youn Um ,  Eun Muk Lim ,  Suk Hwan Cho ,  Si Hyoung Lee

IPC分类号： B60W40/10

CPC分类号： B60T7/22 ,  B60T2201/022 ,  B60W30/17 ,  B60W2550/302 ,  B60W2550/308

摘要： Disclosed is a control method for use in a system for controlling a distance between vehicles. The method comprises a) controlling, in response to the leading vehicle's deceleration, deceleration of the control vehicle; b) controlling stop speed of the control vehicle so that the control vehicle approaches the leading vehicle at a constant speed without stopping; c) controlling the control vehicle to stop smoothly exactly at a position spaced from the leading vehicle by a predetermined stop distance; and d) controlling the start of the control vehicle after determining whether the leading vehicle has started or moved forward.

摘要翻译： 公开了一种用于控制车辆之间的距离的系统中的控制方法。 该方法包括：a）响应于前方车辆的减速度控制控制车辆的减速; b）控制控制车辆的停止速度，使得控制车辆以恒定的速度接近前方车辆而不停止; c）控制所述控制车辆在与所述前方车辆间隔开的位置处准确地停止预定的停止距离; 以及d）在确定前方车辆是开始还是向前移动之后控制控制车辆的起动。