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公开(公告)号：US20080045554A1
公开(公告)日：2008-02-21
申请号：US11766981
申请日：2007-06-22
申请人： Changsheng Zheng , Chu-Biao Xue , Ganfeng Cao , Michael Xia , Anlai Wang , Hai Ye , Brian Metcalf
发明人： Changsheng Zheng , Chu-Biao Xue , Ganfeng Cao , Michael Xia , Anlai Wang , Hai Ye , Brian Metcalf
IPC分类号： A61K31/495 , A61P3/00 , C07D239/00
CPC分类号： C07D487/14
摘要： The present invention relates to purinone derivatives which are agonists of the HM74a receptor. Further provided are compositions and methods of using the compounds herein, and their pharmaceutically acceptable salts for the treatment of disease.
摘要翻译： 本发明涉及作为HM74a受体的激动剂的嘌呤酮衍生物。 还提供了使用本文化合物及其药学上可接受的盐来治疗疾病的组合物和方法。
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公开(公告)号：US07511050B2
公开(公告)日：2009-03-31
申请号：US11766981
申请日：2007-06-22
申请人： Changsheng Zheng , Chu-Biao Xue , Ganfeng Cao , Michael Xia , Anlai Wang , Hai Fen Ye , Brian Metcalf
发明人： Changsheng Zheng , Chu-Biao Xue , Ganfeng Cao , Michael Xia , Anlai Wang , Hai Fen Ye , Brian Metcalf
IPC分类号： A01N43/54 , A61K31/505 , C07D239/00 , C07D471/00 , C07D487/00 , C07D491/00
CPC分类号： C07D487/14
摘要： The present invention relates to purinone derivatives which are agonists of the HM74a receptor. Further provided are compositions and methods of using the compounds herein, and their pharmaceutically acceptable salts for the treatment of disease.
摘要翻译： 本发明涉及作为HM74a受体的激动剂的嘌呤酮衍生物。 还提供了使用本文化合物及其药学上可接受的盐来治疗疾病的组合物和方法。
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公开(公告)号：US08703783B2
公开(公告)日：2014-04-22
申请号：US13275214
申请日：2011-10-17
申请人： Changsheng Zheng , Chu-Biao Xue , Ganfeng Cao , Michael Xia , Anlai Wang , Hai Fen Ye , Brian Metcalf
发明人： Changsheng Zheng , Chu-Biao Xue , Ganfeng Cao , Michael Xia , Anlai Wang , Hai Fen Ye , Brian Metcalf
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D487/14
摘要： The present invention relates to purinone derivatives which are agonists of the HM74a receptor. Further provided are compositions and methods of using the compounds herein, and their pharmaceutically acceptable salts for the treatment of disease.
摘要翻译： 本发明涉及作为HM74a受体的激动剂的嘌呤酮衍生物。 还提供了使用本文化合物及其药学上可接受的盐来治疗疾病的组合物和方法。
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公开(公告)号：US20120035172A1
公开(公告)日：2012-02-09
申请号：US13275214
申请日：2011-10-17
申请人： Changsheng Zheng , Chu-Biao Xue , Ganfeng Cao , Michael Xia , Anlai Wang , Hai Fen Ye , Brian Metcalf
发明人： Changsheng Zheng , Chu-Biao Xue , Ganfeng Cao , Michael Xia , Anlai Wang , Hai Fen Ye , Brian Metcalf
IPC分类号： A61K31/5377 , C07D413/14 , A61P9/12 , A61P3/10 , A61P9/10 , A61P3/06 , C07D471/14 , A61K31/519
CPC分类号： C07D487/14
摘要： The present invention relates to purinone derivatives which are agonists of the HM74a receptor. Further provided are compositions and methods of using the compounds herein, and their pharmaceutically acceptable salts for the treatment of disease.
摘要翻译： 本发明涉及作为HM74a受体的激动剂的嘌呤酮衍生物。 还提供了使用本文化合物及其药学上可接受的盐来治疗疾病的组合物和方法。
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公开(公告)号：US08039478B2
公开(公告)日：2011-10-18
申请号：US12263990
申请日：2008-11-03
申请人： Changsheng Zheng , Chu-Biao Xue , Ganfeng Cao , Michael Xia , Anlai Wang , Hai Fen Ye , Brian Metcalf
发明人： Changsheng Zheng , Chu-Biao Xue , Ganfeng Cao , Michael Xia , Anlai Wang , Hai Fen Ye , Brian Metcalf
IPC分类号： A01N43/54 , A61K31/505 , C07D239/00 , C07D487/00
CPC分类号： C07D487/14
摘要： The present invention relates to purinone derivatives which are agonists of the HM74a receptor. Further provided are compositions and methods of using the compounds herein, and their pharmaceutically acceptable salts for the treatment of disease.
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公开(公告)号：US07462624B2
公开(公告)日：2008-12-09
申请号：US11766990
申请日：2007-06-22
申请人： Chu-Biao Xue , Brian Metcalf , Anlai Wang , Changsheng Zheng , Ganfeng Cao , Ke Zhang
发明人： Chu-Biao Xue , Brian Metcalf , Anlai Wang , Changsheng Zheng , Ganfeng Cao , Ke Zhang
IPC分类号： A01N43/54 , A61K31/505 , C07D239/00 , C07D471/00 , C07D487/00 , C07D491/00
CPC分类号： C07D487/14 , C07D403/14 , C07D487/04
摘要： The present invention relates to purinone derivatives which are agonists of the HM74a receptor. Further provided are compositions and methods of using the compounds herein, and their pharmaceutically acceptable salts for the treatment of disease.
摘要翻译： 本发明涉及作为HM74a受体的激动剂的嘌呤酮衍生物。 还提供了使用本文化合物及其药学上可接受的盐来治疗疾病的组合物和方法。
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公开(公告)号：US20080045555A1
公开(公告)日：2008-02-21
申请号：US11766990
申请日：2007-06-22
申请人： Chu-Biao Xue , Brian Metcalf , Anlai Wang , Changsheng Zheng , Ganfeng Cao , Ke Zhang
发明人： Chu-Biao Xue , Brian Metcalf , Anlai Wang , Changsheng Zheng , Ganfeng Cao , Ke Zhang
IPC分类号： A61K31/505 , A61P7/00 , C07D239/00
CPC分类号： C07D487/14 , C07D403/14 , C07D487/04
摘要： The present invention relates to purinone derivatives which are agonists of the HM74a receptor. Further provided are compositions and methods of using the compounds herein, and their pharmaceutically acceptable salts for the treatment of disease.
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公开(公告)号：US07902205B2
公开(公告)日：2011-03-08
申请号：US12237794
申请日：2008-09-25
申请人： Chu-Biao Xue , Brian Metcalf , Anlai Wang , Changsheng Zheng , Ganfeng Cao , Ke Zhang
发明人： Chu-Biao Xue , Brian Metcalf , Anlai Wang , Changsheng Zheng , Ganfeng Cao , Ke Zhang
IPC分类号： A01N43/54 , A61K31/505 , C07D491/00
CPC分类号： C07D487/14 , C07D403/14 , C07D487/04
摘要： The present invention relates to purinone derivatives which are agonists of the HM74a receptor. Further provided are compositions and methods of using the compounds herein, and their pharmaceutically acceptable salts for the treatment of disease.
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公开(公告)号：US07863285B2
公开(公告)日：2011-01-04
申请号：US12237807
申请日：2008-09-25
申请人： Chu-Biao Xue , Brian Metcalf , Anlai Wang , Changsheng Zheng , Ganfeng Cao , Ke Zhang
发明人： Chu-Biao Xue , Brian Metcalf , Anlai Wang , Changsheng Zheng , Ganfeng Cao , Ke Zhang
IPC分类号： A61K31/505
CPC分类号： C07D487/14 , C07D403/14 , C07D487/04
摘要： The present invention relates to purinone derivatives which are agonists of the HM74a receptor. Further provided are compositions and methods of using the compounds herein, and their pharmaceutically acceptable salts for the treatment of disease.
摘要翻译： 本发明涉及作为HM74a受体的激动剂的嘌呤酮衍生物。 还提供了使用本文化合物及其药学上可接受的盐来治疗疾病的组合物和方法。
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公开(公告)号：US20060020133A1
公开(公告)日：2006-01-26
申请号：US11167329
申请日：2005-06-27
申请人： Chu-Biao Xue , Changsheng Zheng , Hao Feng , Michael Xia , Joseph Glenn , Ganfeng Cao , Brian Metcalf
发明人： Chu-Biao Xue , Changsheng Zheng , Hao Feng , Michael Xia , Joseph Glenn , Ganfeng Cao , Brian Metcalf
IPC分类号： C07D405/14
CPC分类号： C07D309/14 , C07D405/12 , C07D405/14
摘要： The present invention is directed to compounds of Formula I: which are modulators of chemokine receptors. The compounds of the invention, and compositions thereof, are useful in the treatment of diseases related to chemokine receptor expression and/or activity.
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