摘要:
The present invention relates to purinone derivatives which are agonists of the HM74a receptor. Further provided are compositions and methods of using the compounds herein, and their pharmaceutically acceptable salts for the treatment of disease.
摘要:
The invention provides histone deacetylase (HDAC) inhibitors shown as Formula I, where R1 to R8 are as defined in the specification. The invention also provides methods for synthesis of these compounds and applications of these compounds in preparing pharmaceuticals for preventing or treating mammal diseases related to the dysregulation of HDAC.
摘要:
The invention provides histone deacetylase (HDAC) inhibitors shown as Formula I, where R1 to R8 are as defined in the specification. The invention also provides methods for synthesis of these compounds and applications of these compounds in preparing pharmaceuticals for preventing or treating mammal diseases related to the dysregulation of HDAC.
摘要:
Disclosed is a process for indicating the presence of soluble fluoride ions in oral care compositions comprising making a signal solution and then bringing the signal solution into contact with an oral care composition and a color change occurs if an effective amount of soluble fluoride ion is present in the oral care composition. Further disclosed are test compositions for use in such process.
摘要:
The present invention provides a unit dose treatment product comprising: a) a sealed disposable package comprising a laminate wherein the laminate comprises; i) an aluminium barrier layer; and ii) a polymer contact layer selected from polypropylene, polyamide and nylon 12; b) a liquid treatment product contained within the package, wherein the liquid treatment product comprises: i) a film-forming polymer; ii) an organic solvent for the film-forming polymer having a boiling point of less than 150° C. and a solubility parameter of less than 22 (MPa)0.5; and iii) an active agent; wherein the polymer contact layer of the laminate is in contact with the liquid treatment product. Kits comprising the unit dose treatment products and methods of treating the tissues of the oral cavity employing the unit dose treatment products are also provided. The products, kits and methods herein provide for convenient oral treatments, especially tooth whitening treatments using an extended regimen.
摘要:
A hard disk mounting assembly includes a chassis (10), a first cage (20) mounted to the chassis, a hard disk drive(40) (HDD) and a second cage (60). The HDD defines a plurality of fixing openings (42). The first cage includes a plurality of mounting pillars (28) resilient connected with the cage and received in the fixing openings of the HDD at one end portion. The first cage further defines a pair of engaging apertures (34) at opposite sides thereof. The second cage has a base (62) and two connecting arms (68) depending from the base. the base forms a plurality of elastic fingers (66). The first cage is mounted to the chassis and the HDD is received in the first cage, the second cage hitches the first cage by the connecting arms with the elastic fingers pressing the HDD, thereby mounting the HDD to the chassis.
摘要:
Disclosed is a delivery system for delivering an oral care substance to the oral cavity, the delivery system comprising: (a) a removable backing strip having sufficient flexibility so as to be readily conformable to an oral surface when the delivery system is placed thereagainst; and (b) an oral care composition applied to the strip of material such that when the delivery system is placed on the oral surface the oral care composition contacts the oral surface, the oral care composition comprising: (i) an organosiloxane resin; (ii) a theology modifier; and (iii) at least one oral care substance; wherein the oral care composition remains on the oral surface after the backing strip is removed. Further disclosed are such delivery systems in which the oral care composition further comprises fluid diorganopolysiloxane-based polymers; such compositions may further comprise carriers for solubilizing the organosiloxane resin and the fluid diorganopolysiloxane-based polymers. Still further disclosed are methods of using the delivery systems.
摘要:
Disclosed is a delivery system for delivering an oral care substance to the oral cavity, the delivery system comprising: (a) a removable backing strip having sufficient flexibility so as to be readily conformable to an oral surface when the delivery system is placed thereagainst; and (b) an oral care composition applied to the strip of material such that when the delivery system is placed on the oral surface the oral care composition contacts the oral surface, the oral care composition comprising: (i) an organosiloxane resin; (ii) a theology modifier; and (iii) at least one oral care substance; wherein the oral care composition remains on the oral surface after the backing strip is removed. Further disclosed are such delivery systems in which the oral care composition further comprises fluid diorganopolysiloxane-based polymers; such compositions may further comprise carriers for solubilizing the organosiloxane resin and the fluid diorganopolysiloxane-based polymers. Still further disclosed are methods of using the delivery systems.