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    Compositions and methods for immunotherapy of cancer and infectious diseases
    2.
    发明授权
    Compositions and methods for immunotherapy of cancer and infectious diseases 有权
    癌症和传染病免疫治疗的组成和方法

    公开(公告)号：US08257714B2

    公开(公告)日：2012-09-04

    申请号：US12102292

    申请日：2008-04-14

    申请人： Charles Aylsworth ,  Siu-Cheong Ho ,  David Juckett ,  John W. Judge ,  Barnett Rosenberg ,  Igor V. Zlatkin ,  Tatiana Zlatkin

    发明人： Charles Aylsworth ,  Siu-Cheong Ho ,  David Juckett ,  John W. Judge ,  Barnett Rosenberg ,  Igor V. Zlatkin ,  Tatiana Zlatkin

    IPC分类号： A61K39/00 ,  A61K39/002 ,  A61K35/68 ,  A61P31/16

    CPC分类号： A61K39/39 ,  A61K38/16 ,  A61K39/012 ,  A61K2039/55516 ,  C07K14/455

    摘要： The present invention provides compositions and methods for the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases, for stimulating an immune response in a subject, and for use as an alternative to interleukin-12 (IL-12) treatment. In particular, the present invention provides Apicomplexa-related proteins (ARPs) that have immune stimulatory activity and thus have uses in the treatment and prevention of cancer and infectious diseases and in immune modulation. Compositions comprising an ARP are provided. Methods of use of an ARP for the prevention and/or treatment of cancer and/or infectious diseases, for use as an alternative to interleukin-12 (IL-12) treatment, and for eliciting an immune response in a subject, are also provided.

    摘要翻译： 本发明提供用于预防和治疗原发性和转移性肿瘤疾病和感染性疾病，用于刺激受试者的免疫应答并用作白细胞介素-12（IL-12）治疗的替代物的组合物和方法。 特别地，本发明提供了具有免疫刺激活性的Apicocplexa相关蛋白（ARP），因此具有用于治疗和预防癌症和感染性疾病以及免疫调节的用途。 提供了包含ARP的组合。 还提供了用于预防和/或治疗癌症和/或感染性疾病（用作白细胞介素-12（IL-12）治疗的替代物）和用于在受试者中引发免疫应答的方法 。

    Compositions and methods for immunotherapy of cancer and infectious diseases
    3.
    发明授权
    Compositions and methods for immunotherapy of cancer and infectious diseases 有权
    癌症和传染病免疫治疗的组成和方法

    公开(公告)号：US07393534B2

    公开(公告)日：2008-07-01

    申请号：US10892659

    申请日：2004-07-15

    申请人： Charles Aylsworth ,  Siu-Cheong Ho ,  David Juckett ,  John W. Judge ,  Igor V. Zlatkin ,  Tatiana Zlatkin

    发明人： Charles Aylsworth ,  Siu-Cheong Ho ,  David Juckett ,  John W. Judge ,  Igor V. Zlatkin ,  Tatiana Zlatkin

    IPC分类号： A61K38/00 ,  A61K39/00

    CPC分类号： A61K39/39 ,  A61K38/16 ,  A61K39/012 ,  A61K2039/55516 ,  C07K14/455

    摘要： The present invention provides compositions and methods for the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases, for stimulating an immune response in a subject, and for use as an alternative to interleukin-12 (IL-12) treatment. In particular, the present invention provides Apicomplexa-related proteins (ARPs) that have immune stimulatory activity and thus have uses in the treatment and prevention of cancer and infectious diseases and in immune modulation. Compositions comprising an ARP are provided. Methods of use of an ARP for the prevention and/or treatment of cancer and/or infectious diseases, for use as an alternative to interleukin-12 (IL-12) treatment, and for eliciting an immune response in a subject, are also provided.

    摘要翻译： 本发明提供用于预防和治疗原发性和转移性肿瘤疾病和感染性疾病，用于刺激受试者的免疫应答并用作白细胞介素-12（IL-12）治疗的替代物的组合物和方法。 特别地，本发明提供了具有免疫刺激活性的Apicocplexa相关蛋白（ARP），因此具有用于治疗和预防癌症和感染性疾病以及免疫调节的用途。 提供了包含ARP的组合。 还提供了用于预防和/或治疗癌症和/或感染性疾病（用作白细胞介素-12（IL-12）治疗的替代物）和用于在受试者中引发免疫应答的方法 。