利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

10 条记录 (耗时 0.091 秒)

    Compositions and methods for immunotherapy of cancer and infectious diseases
    1.
    发明授权
    Compositions and methods for immunotherapy of cancer and infectious diseases 有权
    癌症和传染病免疫治疗的组成和方法

    公开(公告)号：US07393534B2

    公开(公告)日：2008-07-01

    申请号：US10892659

    申请日：2004-07-15

    申请人： Charles Aylsworth ,  Siu-Cheong Ho ,  David Juckett ,  John W. Judge ,  Igor V. Zlatkin ,  Tatiana Zlatkin

    发明人： Charles Aylsworth ,  Siu-Cheong Ho ,  David Juckett ,  John W. Judge ,  Igor V. Zlatkin ,  Tatiana Zlatkin

    IPC分类号： A61K38/00 ,  A61K39/00

    CPC分类号： A61K39/39 ,  A61K38/16 ,  A61K39/012 ,  A61K2039/55516 ,  C07K14/455

    摘要： The present invention provides compositions and methods for the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases, for stimulating an immune response in a subject, and for use as an alternative to interleukin-12 (IL-12) treatment. In particular, the present invention provides Apicomplexa-related proteins (ARPs) that have immune stimulatory activity and thus have uses in the treatment and prevention of cancer and infectious diseases and in immune modulation. Compositions comprising an ARP are provided. Methods of use of an ARP for the prevention and/or treatment of cancer and/or infectious diseases, for use as an alternative to interleukin-12 (IL-12) treatment, and for eliciting an immune response in a subject, are also provided.

    摘要翻译： 本发明提供用于预防和治疗原发性和转移性肿瘤疾病和感染性疾病，用于刺激受试者的免疫应答并用作白细胞介素-12（IL-12）治疗的替代物的组合物和方法。 特别地，本发明提供了具有免疫刺激活性的Apicocplexa相关蛋白（ARP），因此具有用于治疗和预防癌症和感染性疾病以及免疫调节的用途。 提供了包含ARP的组合。 还提供了用于预防和/或治疗癌症和/或感染性疾病（用作白细胞介素-12（IL-12）治疗的替代物）和用于在受试者中引发免疫应答的方法 。

    Compositions and methods for immunotherapy of cancer and infectious diseases
    3.
    发明授权
    Compositions and methods for immunotherapy of cancer and infectious diseases 有权
    癌症和传染病免疫治疗的组成和方法

    公开(公告)号：US08257714B2

    公开(公告)日：2012-09-04

    申请号：US12102292

    申请日：2008-04-14

    申请人： Charles Aylsworth ,  Siu-Cheong Ho ,  David Juckett ,  John W. Judge ,  Barnett Rosenberg ,  Igor V. Zlatkin ,  Tatiana Zlatkin

    发明人： Charles Aylsworth ,  Siu-Cheong Ho ,  David Juckett ,  John W. Judge ,  Barnett Rosenberg ,  Igor V. Zlatkin ,  Tatiana Zlatkin

    IPC分类号： A61K39/00 ,  A61K39/002 ,  A61K35/68 ,  A61P31/16

    CPC分类号： A61K39/39 ,  A61K38/16 ,  A61K39/012 ,  A61K2039/55516 ,  C07K14/455

    摘要： The present invention provides compositions and methods for the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases, for stimulating an immune response in a subject, and for use as an alternative to interleukin-12 (IL-12) treatment. In particular, the present invention provides Apicomplexa-related proteins (ARPs) that have immune stimulatory activity and thus have uses in the treatment and prevention of cancer and infectious diseases and in immune modulation. Compositions comprising an ARP are provided. Methods of use of an ARP for the prevention and/or treatment of cancer and/or infectious diseases, for use as an alternative to interleukin-12 (IL-12) treatment, and for eliciting an immune response in a subject, are also provided.

    摘要翻译： 本发明提供用于预防和治疗原发性和转移性肿瘤疾病和感染性疾病，用于刺激受试者的免疫应答并用作白细胞介素-12（IL-12）治疗的替代物的组合物和方法。 特别地，本发明提供了具有免疫刺激活性的Apicocplexa相关蛋白（ARP），因此具有用于治疗和预防癌症和感染性疾病以及免疫调节的用途。 提供了包含ARP的组合。 还提供了用于预防和/或治疗癌症和/或感染性疾病（用作白细胞介素-12（IL-12）治疗的替代物）和用于在受试者中引发免疫应答的方法 。

    Compositions and methods for immunotherapy of cancer and infectious diseases
    4.
    发明申请
    Compositions and methods for immunotherapy of cancer and infectious diseases 有权
    癌症和传染病免疫治疗的组成和方法

    公开(公告)号：US20050169935A1

    公开(公告)日：2005-08-04

    申请号：US10892659

    申请日：2004-07-15

    申请人： Charles Aylsworth ,  Siu-Cheong Ho ,  David Juckett ,  John Judge ,  Barnett Rosenberg ,  Igor Zlatkin ,  Tatiana Zlatkin

    发明人： Charles Aylsworth ,  Siu-Cheong Ho ,  David Juckett ,  John Judge ,  Barnett Rosenberg ,  Igor Zlatkin ,  Tatiana Zlatkin

    IPC分类号： A61K38/16 ,  A61K39/00 ,  A61K39/012 ,  A61K39/39 ,  C07K14/455 ,  A61K38/17

    CPC分类号： A61K39/39 ,  A61K38/16 ,  A61K39/012 ,  A61K2039/55516 ,  C07K14/455

    摘要： The present invention provides compositions and methods for the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases, for stimulating an immune response in a subject, and for use as an alternative to interleukin-12 (IL-12) treatment. In particular, the present invention provides Apicomlexa-related proteins (ARPs) that have immune stimulatory activity and thus have uses in the treatment and prevention of cancer and infectious diseases and in immune modulation. Compositions comprising an ARP are provided. Methods of use of an ARP for the prevention and/or treatment of cancer and/or infectious diseases, for use as an alternative to interleukin-12 (IL-12) treatment, and for eliciting an immune response in a subject, are also provided.

    摘要翻译： 本发明提供用于预防和治疗原发性和转移性肿瘤疾病和感染性疾病，用于刺激受试者的免疫应答并用作白细胞介素-12（IL-12）治疗的替代物的组合物和方法。 特别地，本发明提供具有免疫刺激活性的Apicomlexa相关蛋白（ARP），因此具有用于治疗和预防癌症和感染性疾病以及免疫调节的用途。 提供了包含ARP的组合。 还提供了用于预防和/或治疗癌症和/或感染性疾病（用作白细胞介素-12（IL-12）治疗的替代物）和用于在受试者中引发免疫应答的方法 。

    HOSE SYSTEM FOR BILATERAL POSITIVE AIRWAY PRESSURE DEVICE
    6.
    发明申请
    HOSE SYSTEM FOR BILATERAL POSITIVE AIRWAY PRESSURE DEVICE 审中-公开
    双向气动空气压力装置软管系统

    公开(公告)号：US20070272240A1

    公开(公告)日：2007-11-29

    申请号：US11381612

    申请日：2006-05-04

    申请人： Alonzo Aylsworth ,  Charles Aylsworth

    发明人： Alonzo Aylsworth ,  Charles Aylsworth

    IPC分类号： A61M16/00

    CPC分类号： A61M16/0666 ,  A61M16/08 ,  A61M16/0816 ,  A61M2205/14 ,  A61M2205/6045 ,  A61M2205/6063

    摘要： At least some of the illustrative embodiments are hose systems for use with a positive airway pressure device comprising a first hose configured to fluidly couple on a device end to a first outlet of the positive airway pressure device and on a patient end to a first naris of a patient, and a second hose configured to fluidly couple on a device end to a second outlet of the positive airway pressure device and on a patient end to a second naris of the patient (wherein the second hose is fluidly independent from the first hose). The hose system is configured such that the first hose only couples to the first outlet and the second hose only couples to the second outlet.

    摘要翻译： 示例性实施例中的至少一些是用于与气道正压通道装置一起使用的软管系统，其包括第一软管，该第一软管被配置为在装置端部流体地耦合到正气道压力装置的第一出口和患者端到达第一鼻孔 患者和第二软管，所述第二软管构造成在装置端部流体地联接到所述正气道压力装置的第二出口和患者端到所述患者的第二鼻孔（其中所述第二软管与所述第一软管流体独立） 。 软管系统构造成使得第一软管仅耦合到第一出口，而第二软管仅耦合到第二出口。

    Dual chamber humidifier
    7.
    发明申请
    Dual chamber humidifier 审中-公开
    双室加湿器

    公开(公告)号：US20070272239A1

    公开(公告)日：2007-11-29

    申请号：US11409646

    申请日：2006-04-24

    申请人： Alonzo Aylsworth ,  Charles Aylsworth ,  Lawrence Spector

    发明人： Alonzo Aylsworth ,  Charles Aylsworth ,  Lawrence Spector

    IPC分类号： A61M16/00

    CPC分类号： A61M16/16 ,  A61M16/024 ,  A61M16/1075 ,  A61M16/109 ,  A61M2205/123 ,  A61M2205/3368 ,  A61M2209/086

    摘要： At least some of the illustrative embodiments are a humidifier system comprising an outer housing defining an internal volume, a dividing member within the internal volume that divides the internal volume into a first chamber and a second chamber (the first and second chambers fluidly independent of each other), a first inlet port and first outlet port (the first inlet and outlet ports in fluid communication with the first chamber), and second inlet port and a second outlet port (the second inlet and outlet ports in fluid communication with the second chamber).

    摘要翻译： 示例性实施例中的至少一些是加湿器系统，其包括限定内部容积的外部壳体，内部体积内的分隔构件，其将内部容积分成第一腔室和第二腔室（第一腔室和第二腔室流体地独立于每个腔室） 第一入口和第一出口（与第一室流体连通的第一入口和出口）和第二入口和第二出口（与第二室流体连通的第二入口和出口） ）。

    Method and system of coordinating an intensifier and sieve beds
    9.
    发明申请
    Method and system of coordinating an intensifier and sieve beds 有权
    协调增压器和筛床的方法和系统

    公开(公告)号：US20070214955A1

    公开(公告)日：2007-09-20

    申请号：US11377594

    申请日：2006-03-16

    申请人： Alonzo Aylsworth ,  Charles Aylsworth

    发明人： Alonzo Aylsworth ,  Charles Aylsworth

    IPC分类号： B01D46/46

    CPC分类号： B01D53/0454 ,  B01D53/0446 ,  B01D53/047 ,  B01D2259/402 ,  B01D2259/4533 ,  B01D2259/4541

    摘要： A method and system of coordinating an intensifier and sieve beds. At least some of the illustrative embodiments are methods comprising coordinating control of an intensifier with cycles of a sieve bed fluidly coupled to the intensifier such that there is at least one low pressure stroke of the intensifier and at least one high pressure stroke of the intensifier during a fill cycle of the sieve bed.

    摘要翻译： 协调增压器和筛床的方法和系统。 示例性实施例中的至少一些是包括将增压器与流体耦合到增压器的筛床的循环协调控制的方法，使得在增压器中存在至少一个低压冲程和增压器的至少一个高压冲程 筛床的填充循环。

    Nasal cannula
    10.
    发明申请
    Nasal cannula 有权
    鼻插管

    公开(公告)号：US20050257794A1

    公开(公告)日：2005-11-24

    申请号：US11053587

    申请日：2005-02-08

    申请人： Alonzo Aylsworth ,  Charles Aylsworth ,  Lawrence Spector

    发明人： Alonzo Aylsworth ,  Charles Aylsworth ,  Lawrence Spector

    IPC分类号： A61M15/08 ,  A61M16/00 ,  A61M16/06 ,  A61M16/10

    CPC分类号： A61M16/0666 ,  A61M16/1055 ,  A61M2210/0625

    摘要： An improved nasal cannula. Some illustrative embodiments are a cannula comprising a first nasal tube having a device end and an aperture end (wherein the cannula is configured to place the aperture end in fluid communication with the first naris of a patient), a second nasal tubing having a device end and an aperture end (wherein the cannula is configured to place the aperture end of the second nasal tubing in fluid communication with a second naris of the patient), and an oral tubing having a device end and an aperture end, and the oral tubing mechanically coupled to at least one of the first or second nasal tubing (wherein the cannula is configured to place the aperture end of the oral tubing in fluid communication with the mouth of a patient). The first nasal tubing, the second nasal tubing and the oral tubing are fluidly independent between their aperture ends and their device ends.

    摘要翻译： 改进的鼻插管。 一些说明性实施例是包括具有装置端和孔端的第一鼻管的插管（其中套管被配置为将开口端与患者的第一鼻孔流体连通），具有装置端部的第二鼻管 和孔径端（其中套管被配置为将第二鼻管的开口端与患者的第二鼻孔流体连通），以及具有装置端和孔端的口腔管，以及机械的口腔管 耦合到第一或第二鼻管中的至少一个（其中插管被配置为将口腔管的开口端与患者的口部流体连通）。 第一鼻管，第二鼻管和口腔管在它们的孔端和它们的装置端之间是流体上独立的。