公开(公告)号：US20050163725A1

公开(公告)日：2005-07-28

申请号：US10900992

申请日：2004-07-28

申请人： Charles Blizzard ,  John Chipman ,  Gordon Cutler ,  Blair Jackson ,  Lloyd Johnston ,  Richard Lucas ,  Jeffrey Mintzes

发明人： Charles Blizzard ,  John Chipman ,  Gordon Cutler ,  Blair Jackson ,  Lloyd Johnston ,  Richard Lucas ,  Jeffrey Mintzes

IPC分类号： A61K9/16 ,  A61K38/27 ,  A61K9/14 ,  A61L9/04

CPC分类号： A61K38/27 ,  A61K9/0073 ,  A61K9/1611

摘要： The claimed invention relates to a method of treating a human patient with growth hormone deficiency or a non-growth hormone deficiency disorder treatable with hGH, which comprises administering human growth hormone to the deep lung to said patient by a pulmonary device.

摘要翻译： 所要求保护的发明涉及用生长激素缺乏或非生长激素缺乏症治疗hGH可治疗人类患者的方法，所述方法包括通过肺部装置向所述患者施用人生长激素给深部肺。

公开(公告)号：US20080108554A1

公开(公告)日：2008-05-08

申请号：US12007041

申请日：2008-01-04

申请人： Blair Jackson ,  Lloyd Johnston ,  Ernest Penachio ,  Charles Blizzard ,  Marie Chung ,  Jean Sung

发明人： Blair Jackson ,  Lloyd Johnston ,  Ernest Penachio ,  Charles Blizzard ,  Marie Chung ,  Jean Sung

IPC分类号： A61K38/28

CPC分类号： A61K9/0075 ,  A61K9/1611 ,  A61K9/1617 ,  A61K9/1688 ,  A61K9/1694 ,  A61K31/137 ,  A61K38/27 ,  A61K38/28 ,  B01D1/18 ,  B01F3/0803 ,  B01F5/0619 ,  B01J2/04 ,  B01J2/10

摘要： Method and apparatus for producing dry particles. Two liquid components are combined in a static mixer, atomized into droplets, and the droplets dried to form dry particles. Use of the static mixer enables incompatible liquid components to be rapidly and homogeneously combined. The present invention optimizes process conditions for increasing and controlling particle porosity. The present invention also allows for optimization of particle size in real-time during particle production.

摘要翻译： 用于生产干颗粒的方法和设备 将两个液体组分在静态混合器中组合，雾化成液滴，并将液滴干燥以形成干燥颗粒。 使用静态混合器可使不兼容的液体组分快速均匀地组合。 本发明优化了增加和控制颗粒孔隙率的工艺条件。 本发明还允许在颗粒生产期间实时优化粒度。

公开(公告)号：US08409606B2

公开(公告)日：2013-04-02

申请号：US12704692

申请日：2010-02-12

申请人： Amarpreet S. Sawhney ,  Peter Jarrett ,  Michael Bassett ,  Charles Blizzard

发明人： Amarpreet S. Sawhney ,  Peter Jarrett ,  Michael Bassett ,  Charles Blizzard

IPC分类号： A61F2/00 ,  B29B9/06 ,  A01N43/42 ,  A01N37/08 ,  A61K31/44 ,  A61K31/215

CPC分类号： A61K9/0051 ,  A61B17/12099 ,  A61B17/12159 ,  A61B17/1219 ,  A61F9/00772 ,  A61F2250/0067 ,  A61K31/135 ,  A61K31/437

摘要： An embodiment is a medical prosthesis for blocking or reducing tear flow through a punctum or canaliculus of a human eye and delivering a drug to the eye that comprises a dehydrated covalently crosslinked synthetic hydrophilic polymer hydrogel with dimensions to pass through a puncta lacrimali, with the dehydrated hydrogel absorbing physiological water to swell to at least 1 mm in cross-sectional width and conformably fit a canaliculus, with the hydrogel comprising a therapeutic agent dispersed through the hydrogel for release to an eye, with the hydrogel having a water content of at least about 50% by weight or volume when allowed to fully hydrate in vitro in physiological saline.

摘要翻译： 一个实施方案是用于阻断或减少穿过人眼的泪点或泪管的泪液的药物假体，并将药物递送到眼睛，该药物包括脱水的共价交联的合成亲水性聚合物水凝胶，其尺寸通过泪点，脱水 水凝胶吸收生理水以横截面宽度膨胀至至少1mm，并且顺应地配合小孔，其中水凝胶包含分散在水凝胶中的治疗剂以释放至眼睛，水凝胶的水含量至少约为 当在生理盐水中体外充分水合时，其重量为50％或体积。

公开(公告)号：US20080063722A1

公开(公告)日：2008-03-13

申请号：US11838468

申请日：2007-08-14

申请人： Kevin Ward ,  Thean Yeoh ,  Rebecca Martin ,  Charles Blizzard

发明人： Kevin Ward ,  Thean Yeoh ,  Rebecca Martin ,  Charles Blizzard

IPC分类号： A61K9/14 ,  A61K33/14 ,  A61P31/16

CPC分类号： A61K31/351 ,  A61K9/0075 ,  A61K9/1611 ,  A61K9/1617 ,  A61K31/196

摘要： The present invention is related to pharmaceutical formulations and methods of treating a subject afflicted with the influenza virus, the method includes administering to the respiratory tract of the patient particles that include more than about 5% to about 50% weight percent (wt %) of a neuraminidase inhibitor. The particles are delivered to the patient's pulmonary system, including the upper airways, central airways and deep lung.

摘要翻译： 本发明涉及治疗患有流感病毒的受试者的药物制剂和方法，所述方法包括对患者颗粒的呼吸道施用包括大于约5％至约50％重​​量百分比（wt％）的 神经氨酸酶抑制剂。 颗粒被递送到患者的肺部系统，包括上呼吸道，中央气道和深肺。

公开(公告)号：US20100209478A1

公开(公告)日：2010-08-19

申请号：US12704692

申请日：2010-02-12

申请人： Amarpreet S. Sawhney ,  Peter Jarrett ,  Michael Bassett ,  Charles Blizzard

发明人： Amarpreet S. Sawhney ,  Peter Jarrett ,  Michael Bassett ,  Charles Blizzard

IPC分类号： A61F2/14 ,  A61K31/437 ,  A61K31/135 ,  A61P27/02 ,  A61P27/06 ,  B29B9/06

CPC分类号： A61K9/0051 ,  A61B17/12099 ,  A61B17/12159 ,  A61B17/1219 ,  A61F9/00772 ,  A61F2250/0067 ,  A61K31/135 ,  A61K31/437

摘要： An embodiment is a medical prosthesis for blocking or reducing tear flow through a punctum or canaliculus of a human eye and delivering a drug to the eye that comprises a dehydrated covalently crosslinked synthetic hydrophilic polymer hydrogel with dimensions to pass through a puncta lacrimali, with the dehydrated hydrogel absorbing physiological water to swell to at least 1 mm in cross-sectional width and conformably fit a canaliculus, with the hydrogel comprising a therapeutic agent dispersed through the hydrogel for release to an eye, with the hydrogel having a water content of at least about 50% by weight or volume when allowed to fully hydrate in vitro in physiological saline.

摘要翻译： 一个实施方案是用于阻断或减少穿过人眼的泪点或泪管的泪液的药物假体，并将药物递送到眼睛，所述药物包括脱水的共价交联的合成亲水性聚合物水凝胶，其尺寸通过泪点，脱水 水凝胶吸收生理水以横截面宽度膨胀至至少1mm，并且顺应地配合小孔，其中水凝胶包含分散在水凝胶中的治疗剂以释放至眼睛，水凝胶的水含量至少约为 当在生理盐水中体外充分水合时，其重量为50％或体积。