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    Highly efficient delivery of a large therapeutic mass aerosol
    5.
    发明授权
    Highly efficient delivery of a large therapeutic mass aerosol 有权

    公开(公告)号：US07556798B2

    公开(公告)日：2009-07-07

    申请号：US09878146

    申请日：2001-06-08

    申请人： David A. Edwards ,  Richard P. Batycky ,  Lloyd Johnston

    发明人： David A. Edwards ,  Richard P. Batycky ,  Lloyd Johnston

    IPC分类号： A61K9/12 ,  A61K9/14

    CPC分类号： A61K9/14 ,  A61K9/0075 ,  A61K9/1617 ,  A61K31/198

    摘要： A method for delivering an agent to the pulmonary system, in a single, breath-activated step or a single breath, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50% of the mass of particles. The particles are capable of carrying agents. The agent is (1) part of the spray-drying pre-mixture and thereby incorporated into the particles, (2) added to separately-prepared particles so that the agent is in chemical association with the particles or (3) blended so that the agent is mixed with, and co-delivered with the particles.Respirable compositions comprising carrier particles having a tap density of less than 0.4 g/cm3 and a composition comprising an agent are also disclosed. Methods of delivering these respirable compositions are also included.

    Highly Efficient Delivery of a Large Therapeutic Mass Aerosol
    6.
    发明申请
    Highly Efficient Delivery of a Large Therapeutic Mass Aerosol 有权
    高效率地输送大型治疗性质量气溶胶

    公开(公告)号：US20120093893A1

    公开(公告)日：2012-04-19

    申请号：US13334236

    申请日：2011-12-22

    申请人： David A. Edwards ,  Richard P. Batycky ,  Lloyd Johnston

    发明人： David A. Edwards ,  Richard P. Batycky ,  Lloyd Johnston

    IPC分类号： A61K9/14 ,  A61P11/00 ,  A61K31/192 ,  A61K31/137 ,  A61K31/138 ,  A61K31/198

    CPC分类号： A61K9/14 ,  A61K9/0075 ,  A61K9/1617 ,  A61K31/198

    摘要： A method for delivering an agent to the pulmonary system, in a single, breath-activated step or a single breath, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50% of the mass of particles. The particles are capable of carrying agents. The agent is (1) part of the spray-drying pre-mixture and thereby incorporated into the particles, (2) added to separately-prepared particles so that the agent is in chemical association with the particles or (3) blended so that the agent is mixed with, and co-delivered with the particles.Respirable compositions comprising carrier particles having a tap density of less than 0.4 g/cm3 and a composition comprising an agent are also disclosed. Methods of delivering these respirable compositions are also included.

    摘要翻译： 用于在单个呼吸激活步骤或单次呼吸中将药物递送至肺部系统的方法包括从包围大量颗粒的容器向受试者的呼吸道施用具有小于 0.4克/厘米3，并输送至少约50％的颗粒。 颗粒能够携带。 试剂是（1）部分喷雾干燥预混合物，由此加入到颗粒中，（2）加入到单独制备的颗粒中，使得试剂与颗粒化学缔合，或（3）混合 试剂与颗粒混合并与颗粒共同传送。 还公开了包含振实密度小于0.4g / cm 3的载体颗粒和包含试剂的组合物的可吸入组合物。 还包括递送这些可呼吸组合物的方法。

    Control of process humidity to produce large, porous particles
    8.
    发明授权
    Control of process humidity to produce large, porous particles 有权
    控制工艺湿度以产生大的多孔颗粒

    公开(公告)号：US07469488B2

    公开(公告)日：2008-12-30

    申请号：US10977088

    申请日：2004-10-29

    申请人： Donghao Chen ,  Richard P. Batycky ,  Lloyd Johnston ,  Jeffrey Mintzes

    发明人： Donghao Chen ,  Richard P. Batycky ,  Lloyd Johnston ,  Jeffrey Mintzes

    IPC分类号： E02F5/10 ,  A01N25/02 ,  A61K9/14 ,  A05D7/00

    CPC分类号： A61K9/0075 ,  A61K9/1694 ,  Y10S514/951

    摘要： Spray dried particles having specified aerodynamic characteristics are produced by atomizing a liquid feed and contacting the liquid feed with a drying gas, such as, for example, air or nitrogen. The humidity of the drying gas is controlled to a value, expressed, for instance, as dew point, which is known to produce particles having a specified tap density or aerodynamic diameter. Particles having a volume median geometric diameter greater than about 5 microns and a tap density less than about 0.4 g/cm3 are preferred.

    摘要翻译： 通过雾化液体进料并使液体进料与例如空气或氮气的干燥气体接触来产生具有特定空气动力特性的喷雾干燥颗粒。 干燥气体的湿度被控制为例如表示为露点，其已知产生具有特定振实密度或空气动力学直径的颗粒。 体积中值几何直径大于约5微米且振实密度小于约0.4g / cm 3的颗粒是优选的。

    Highly efficient delivery of a large therapeutic mass aerosol
    9.
    发明授权
    Highly efficient delivery of a large therapeutic mass aerosol 有权
    高效率地传送大量治疗性气溶胶

    公开(公告)号：US08628754B2

    公开(公告)日：2014-01-14

    申请号：US13334236

    申请日：2011-12-22

    申请人： David A. Edwards ,  Richard P. Batycky ,  Lloyd Johnston

    发明人： David A. Edwards ,  Richard P. Batycky ,  Lloyd Johnston

    IPC分类号： A61K9/14

    CPC分类号： A61K9/14 ,  A61K9/0075 ,  A61K9/1617 ,  A61K31/198

    摘要： A method for delivering an agent to the pulmonary system, in a single, breath-activated step or a single breath, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50% of the mass of particles. The particles are capable of carrying agents. The agent is (1) part of the spray-drying pre-mixture and thereby incorporated into the particles, (2) added to separately-prepared particles so that the agent is in chemical association with the particles or (3) blended so that the agent is mixed with, and co-delivered with the particles.Respirable compositions comprising carrier particles having a tap density of less than 0.4 g/cm3 and a composition comprising an agent are also disclosed. Methods of delivering these respirable compositions are also included.

    摘要翻译： 用于在单个呼吸激活步骤或单次呼吸中将药物递送至肺部系统的方法包括从包围大量颗粒的容器向受试者的呼吸道施用具有小于 0.4克/厘米3，并输送至少约50％的颗粒。 颗粒能够携带。 试剂是（1）部分喷雾干燥预混合物，由此加入到颗粒中，（2）加入到单独制备的颗粒中，使得试剂与颗粒化学缔合，或（3）混合 试剂与颗粒混合并与颗粒共同传送。 还公开了包含振实密度小于0.4g / cm 3的载体颗粒和包含试剂的组合物的可吸入组合物。 还包括递送这些可呼吸组合物的方法。