利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

30 条记录 (耗时 0.03 秒)

    Compounds with (1 E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof
    7.
    发明授权
    Compounds with (1 E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof 有权
    具有（1E，6E）-1,7-双 - （3,4-二甲氧基苯基）-4,4-二取代 - 七-1,6-二烯-3,5-二酮结构支架的化合物，其生物活性，和 其用途

    公开(公告)号：US08710272B2

    公开(公告)日：2014-04-29

    申请号：US13525941

    申请日：2012-06-18

    申请人： Charles C. Y. Shih ,  Qian Shi ,  Hui-Kang Wang ,  Ching-Yuan Su

    发明人： Charles C. Y. Shih ,  Qian Shi ,  Hui-Kang Wang ,  Ching-Yuan Su

    IPC分类号： C07C49/255 ,  C07C235/78 ,  C07D277/46 ,  C07D295/192 ,  A61K31/12

    CPC分类号： C07C49/255 ,  A61K31/12 ,  A61K31/135 ,  A61K31/165 ,  A61K31/216 ,  A61K31/426 ,  A61K31/5375 ,  C07C235/78 ,  C07D277/46 ,  C07D295/192

    摘要： The present invention includes compounds, pharmaceuticals and cosmetics having at least one (substituted phenyl)-propenal moiety. The compounds and compositions of the present invention are useful in the treatment or prevention of medical conditions including androgen associated conditions, androgen associated inflammation, a wound (the compounds assist with wound healing), acne, rheumatoid arthritis, psoriasis, rosacea, and alopecia; Kennedy's disease (spinal and bulbar muscular atrophy, or SBMA), polyglutamine-mediated motor neuron degeneration; cancers such as prostate cancer, bladder cancer, breast cancer, ovarian cancer, hepatocellular (liver) cancer, and pancreatic cancer; and other medical conditions described herein. Treatment of such medical conditions includes administering to an individual suffering from a medical condition describe herein, a therapeutically effective amount of any of the disclosed compounds, their derivatives, or pharmaceutical compositions thereof.

    摘要翻译： 本发明包括具有至少一个（取代的苯基） - 丙烯酸部分的化合物，药物和化妆品。 本发明的化合物和组合物可用于治疗或预防包括雄激素相关病症，雄激素相关炎症，伤口（辅助伤口愈合的化合物），痤疮，类风湿性关节炎，牛皮癣，酒渣鼻和脱发的医学病症; 肯尼迪病（脊髓和延髓肌肉萎缩或SBMA），聚谷氨酰胺介导的运动神经元变性; 癌症如前列腺癌，膀胱癌，乳腺癌，卵巢癌，肝细胞癌（肝癌）和胰腺癌; 和本文所述的其它医学病症。 治疗这样的医学病症包括对患有本文所述的医学病症的个体施用治疗有效量的任何所公开的化合物，其衍生物或其药物组合物。

    Taxoid conjugates as antimitotic and antitumor agents
    10.
    发明授权
    Taxoid conjugates as antimitotic and antitumor agents 失效
    紫杉烷类缀合物作为抗生素和抗肿瘤剂

    公开(公告)号：US06624317B1

    公开(公告)日：2003-09-23

    申请号：US09669156

    申请日：2000-09-25

    申请人： Kuo-Hsiung Lee ,  Qian Shi ,  Kenneth F. Bastow ,  Hui-Kang Wang

    发明人： Kuo-Hsiung Lee ,  Qian Shi ,  Kenneth F. Bastow ,  Hui-Kang Wang

    IPC分类号： C07D30500

    CPC分类号： C07D405/12 ,  A61K47/55 ,  A61K47/552 ,  A61K47/555 ,  C07D305/14 ,  C07D471/04 ,  C07D493/04 ,  C07H15/26 ,  C07H17/02

    摘要： Compounds according to formula I: T1—L—T2   (I), wherein T1 is a taxoid group, preferably of Formula II: wherein R1 is C6H5; R2 is O; L is a linking group; and T2 is a substituent selected from the group consisting of epipodophyllotoxin, amsacrine, ellipticine, anthracycline antibiotic, mitoxantrone, and colchicine groups, and pharmaceutically acceptable salts thereof, are provided herein. The compounds are useful in, among other things, treating tumors or cancer in subjects in need thereof, inducing cellular differentiation, and inhibiting cellular mitosis.

    摘要翻译： 根据式I的化合物：其中T1是紫杉烷基，优选式II：其中R1是C6H5; R2是O; L是连接基团; 并且T2是选自表鬼臼毒素，amsacrine，玫瑰树碱，蒽环类抗生素，米托蒽醌和秋水仙素基团的取代基及其药学上可接受的盐。 除其他外，该化合物可用于治疗有需要的受试者的肿瘤或癌症，诱导细胞分化和抑制细胞有丝分裂。