公开(公告)号：US08496835B2

公开(公告)日：2013-07-30

申请号：US11564951

申请日：2006-11-30

申请人： Charles Little ,  Barry L. Haymore

发明人： Charles Little ,  Barry L. Haymore

IPC分类号： B01D15/08 ,  C02F1/28 ,  G01N30/02

CPC分类号： B01D15/422 ,  B01D15/363 ,  C07C309/11 ,  C07C309/32 ,  C07C309/39 ,  C07C309/42 ,  C07C309/58 ,  C07C309/60 ,  C07C2603/26 ,  C07D251/70 ,  C07D263/57

摘要： A displacement chromatography process, including: loading onto a stationary phase comprising an anion-exchange material a mixture comprising one or more components to be separated; and displacing at least one of the one or more components from the stationary phase by applying to the stationary phase a mixture comprising an polyaromatic polyanionic displacer compound having a general formula Cen(Ar)w, in which Cen is a central bond or group, Ar is an aromatic nucleus, w=2 to the maximum number of sites one Cen, and Ar is substituted with a plurality of An−, in which each An− is independently defined as sulfonate, carboxylate, phosphonate, phosphate, sulfate; and Ar is further substituted with a plurality of G, in which G is defined as independently H, C1-C6 alkyl, halogen, nitro, hydroxy, or C1-C6 alkoxy. In addition, a group of polyaromatic polyanionic displacer compounds useful in the process is disclosed.

摘要翻译： 一种置换色谱方法，包括：将包含一种或多种要分离的组分的混合物装载到包含阴离子交换材料的固定相上; 并通过向固定相施加包含具有通式Cen（Ar）w的多芳族聚阴离子置换剂化合物的混合物，其中Cen为中心键或基团Ar，将来自固定相中的至少一种组分置换为Ar 是芳族核，w = 2至最大数目的一个Cen，Ar被多个An-取代，其中每个An-独立地定义为磺酸酯，羧酸酯，膦酸酯，磷酸酯，硫酸酯; 并且Ar进一步被多个G取代，其中G独立地定义为H，C 1 -C 6烷基，卤素，硝基，羟基或C 1 -C 6烷氧基。 此外，还公开了一组在该方法中有用的多芳族聚阴离子置换剂化合物。

公开(公告)号：US20100081844A1

公开(公告)日：2010-04-01

申请号：US12630985

申请日：2009-12-04

申请人： Charles Little ,  Victor van de Pas ,  Barry Haymore

发明人： Charles Little ,  Victor van de Pas ,  Barry Haymore

IPC分类号： C07C211/00

CPC分类号： B01D15/422 ,  C08G73/0226 ,  G01N30/96

摘要： A chemical compound having the general formula (I): wherein: each group R1, R2, R3, R′1, R′2, and R′3 is alkyl, aryl, or aralkyl; each R4, R′4, R5 and R′5 is alkyl, aryl, aralkyl or —(CH2)a—(CHY)b—(CH2)c—N+R1R2R3An−; each Y is —H, —OH, —OR6, halo, alkyl, aryl or aralkyl, wherein -R6 may be alkyl or —(CH2)a—(CHOH)b—(CH2)c—N+R1R2R3An−, and at least one Y is other than —OH or —OR6; each q and z is from 0 to about 6, and q+z is 1 to about 6; each a, b, and c is from 0 to 2, and a+b+c in any fragment is from 3 to 6; and each An− independently may be one or more or a mixture of organic or inorganic, monovalent or polyvalent anion as needed to obtain a neutral compound.

摘要翻译： 具有通式（I）的化合物：其中：R 1，R 2，R 3，R'1，R'2和R'3各自为烷基，芳基或芳烷基; 每个R 4，R'4，R 5和R 5是烷基，芳基，芳烷基或 - （CH 2）a - （CHY）b - （CH 2）c -N + R 1 R 2 R 3 AN-; 每个Y是-H，-OH，-OR 6，卤素，烷基，芳基或芳烷基，其中-R 6可以是烷基或 - （CH 2）a - （CHOH）b-（CH 2）c -N + R 1 R 2 R 3 A - 至少一个Y不是-OH或-OR6; 每个q和z为0至约6，q + z为1至约6; 每个a，b和c为0至2，任何片段中的a + b + c为3至6; 并且每个An-独立地可以是一种或多种或有机或无机，单价或多价阴离子的混合物，以获得中性化合物。

公开(公告)号：US20060288073A1

公开(公告)日：2006-12-21

申请号：US11158275

申请日：2005-06-20

申请人： Aditya Bansod ,  Charles Little ,  Jason Walter

发明人： Aditya Bansod ,  Charles Little ,  Jason Walter

IPC分类号： G06F15/16

CPC分类号： H04L63/061 ,  H04L67/02

摘要： Publicly accessible linking information is to establish a trusted relationship between reciprocally linked entities controlling web resources, such as websites or web logs. A method of establishing a trust relationship between two entities identifying a user-installed link to a second web resource in a first web resource. Next, the method determines when a reciprocal link is made in the second web resource directed to the first web resource and creates a trust relationship between the entities based on the reciprocal link.

摘要翻译： 可公开访问的链接信息是建立控制Web资源的相互联系的实体（如网站或Web日志）之间的可信关系。 一种在两个实体之间建立标识在第一web资源中的第二web资源的用户安装链接之间的信任关系的方法。 接下来，该方法确定何时在针对第一web资源的第二web资源中做出相互链接，并且基于相互链接在实体之间创建信任关系。

公开(公告)号：US20050251555A1

公开(公告)日：2005-11-10

申请号：US10828401

申请日：2004-04-20

申请人： Charles Little

发明人： Charles Little

IPC分类号： G06F15/16 ,  H04L29/08

CPC分类号： H04L69/329 ,  H04L51/043 ,  H04L67/24

摘要： Subject matter includes systems and methods for presence-based messaging. In one implementation an engine detects the real-time presence of a potential message recipient who can be reached via a communications medium that a sender composing a message is not currently using. The engine can either transition to an environment for composing and sending the message using the detected presence-based communications medium or offer the sender a choice of switching to the presence-based communication medium.

摘要翻译： 主题包括基于在线消息传递的系统和方法。 在一个实现中，引擎检测可以通过通信媒体到达组合消息的发送者当前未使用的潜在消息接收者的实时存在。 引擎可以转换到使用检测到的基于存在的通信介质来撰写和发送消息的环境，或者向发送者提供切换到基于存在的通信介质的选择。

公开(公告)号：US20050267944A1

公开(公告)日：2005-12-01

申请号：US10858963

申请日：2004-06-01

申请人： Charles Little

发明人： Charles Little

IPC分类号： G06F13/00 ,  G06Q10/00 ,  G06F15/16

CPC分类号： G06Q10/107

摘要： An email manager for an inbox directs emails to various categories based on importance assigned by an email recipient and provides a user interface for presenting emails to the recipient in groups prioritized by importance. In one implementation importance is based on the sending source and in one implementation importance is based on content.

摘要翻译： 收件箱的电子邮件管理器根据电子邮件收件人分配的重要性将电子邮件引导到各种类别，并提供用户界面，用于以重要性为重点的组以收件人的形式向收件人发送电子邮件。 在一个实现中，重要性基于发送源，并且在一个实现中，重要性基于内容。

公开(公告)号：US20050246420A1

公开(公告)日：2005-11-03

申请号：US10835373

申请日：2004-04-28

申请人： Charles Little

发明人： Charles Little

IPC分类号： G06F13/00 ,  G06Q10/00 ,  H04L12/58 ,  G06F15/16 ,  G06F15/173

CPC分类号： H04L51/12 ,  G06Q10/107

摘要： Social network email filtering is described. A user's address book includes a first group of email addresses. Those email addresses are used to identify address books that include another group of email addresses. Multiple iterations may be used to identify several groups of email addresses, representing a user's social network. When an email message addressed to the user is received, the message is trusted if the sending email address is within the user's social network. Otherwise, the message is flagged as junk mail. Varying trust levels may be applied to messages that are received based on a distance within a social network between the sending email address and the user and/or how often the sending email address appears within the social network.

摘要翻译： 描述社交网络电子邮件过滤。 用户的通讯录包括第一组电子邮件地址。 这些电子邮件地址用于识别包括另一组电子邮件地址的地址簿。 可以使用多次迭代来标识几组电子邮件地址，代表用户的社交网络。 当接收到发送给用户的电子邮件消息时，如果发送的电子邮件地址在用户的社交网络内，则该信息是信任的。 否则，该邮件将被标记为垃圾邮件。 不同的信任级别可以应用于基于发送电子邮件地址和用户之间的社交网络内的距离和/或发送电子邮件地址在社交网络中出现的频率而接收的消息。

公开(公告)号：US07632409B2

公开(公告)日：2009-12-15

申请号：US11551765

申请日：2006-10-23

申请人： Charles Little ,  Victor van de Pas ,  Barry Haymore

发明人： Charles Little ,  Victor van de Pas ,  Barry Haymore

IPC分类号： B01D15/08

CPC分类号： B01D15/422 ,  C08G73/0226 ,  G01N30/96

摘要： A displacement chromatography process and displacer compounds used in the process and having the general formula (I): wherein: each group R1, R2, R3, R′1, R′2, and R′3, independently may be selected from alkyl, aryl, and aralkyl, and in which a ring containing one or more quaternary nitrogen may be formed by any one or more of R1 and R2, R1 and R′1, R1 and R4, R4 and R′4, or R4 and R5; each R4, R′4, R5 and R′5 independently may be selected from alkyl, aryl, aralkyl and —(CH2)a—(CHY)b—(CH2)c—N+R1R2R3 An−, wherein R1, R2 and R3 are as defined above; each Y independently may be selected from —H, —OH, —OR6, halo, alkyl, aryl and aralkyl, wherein —R6 may be alkyl or —(CH2)a—(CHOH)b—(CH2)c—N+R1R2R3 An−, wherein R1, R2 and R3 are as defined above; each q and z independently may be any whole number from 0 to about 6, with the proviso that q+z is equal to or less than about 6; each a, b, and c independently may be any whole number from 0 to 2, with the proviso that the sum a+b+c in any fragment is at least 1; and each An− independently may be one or more organic or inorganic, monovalent or polyvalent anion as needed to obtain a neutral compound.

摘要翻译： 在该方法中使用的具有通式（I）的置换色谱法和置换剂化合物：其中：每个基团R 1，R 2，R 3，R'1，R'2和R'3独立地可选自烷基， 芳基和芳烷基，其中含有一个或多个季氮的环可以由R 1和R 2，R 1和R'1，R 1和R 4，R 4和R'4或R 4和R 5中的任何一个或多个形成。 每个R 4，R'4，R 5和R 5独立地可以选自烷基，芳基，芳烷基和 - （CH 2）a - （CHY）b - （CH 2）c -N + R 1 R 2 R 3 An-，其中R 1， R3如上所定义; 每个Y独立地可以选自-H，-OH，-OR6，卤素，烷基，芳基和芳烷基，其中-R6可以是烷基或 - （CH2）a-（CHOH）b-（CH2）c-N + R1R2R3 An-，其中R1，R2和R3如上定义; 每个q和z独立地可以是0至约6的任何整数，条件是q + z等于或小于约6; 每个a，b和c独立地可以是0至2的任何整数，条件是任何片段中的和a + b + c之和至少为1; 并且每个An-独立地可以是一种或多种获得中性化合物所需的有机或无机，一价或多价阴离子。

公开(公告)号：US20070136430A1

公开(公告)日：2007-06-14

申请号：US11301862

申请日：2005-12-13

申请人： Imran Qureshi ,  Thomas Leung ,  Pablo Stern ,  William Hoffman ,  Eliot Gillum ,  Omar Shahine ,  Michael Schackwitz ,  Roberto Figueroa ,  Vikram Sardesai ,  Robin Boyea ,  Charles Little

发明人： Imran Qureshi ,  Thomas Leung ,  Pablo Stern ,  William Hoffman ,  Eliot Gillum ,  Omar Shahine ,  Michael Schackwitz ,  Roberto Figueroa ,  Vikram Sardesai ,  Robin Boyea ,  Charles Little

IPC分类号： G06F15/16

CPC分类号： H04L51/30 ,  H04L51/34

摘要： A delivery confirmation is provided to the sender of an e-mail message. When the e-mail message is composed, a link, such as a hyperlink, is inserted into the e-mail message, such as in the body or header. The link can include information such as a message identifier and identifiers of the sender and the recipient, which are provided as a query string of the link, while a host field of the link includes the address of an e-mail/web server. When the recipient receives the e-mail message and opens it, the link is displayed along with text that instructs the user to use the link to confirm delivery. The confirmation can include displaying indicia for the e-mail message in a folder view on an interface of the sender, or sending a confirmation e-mail message to the sender, for instance. Voting by e-mail can also be provided.

摘要翻译： 向电子邮件的发送者提供发送确认。 当电子邮件组合时，诸如超链接的链接被插入电子邮件消息中，例如在主体或头部中。 链接可以包括作为链接的查询字符串提供的信息，例如消息标识符和发送者和接收者的标识符，而链接的主机字段包括电子邮件/ web服务器的地址。 当收件人收到电子邮件并打开邮件时，会显示链接以及指示用户使用链接确认传送的文字。 该确认可以包括在发送者的接口上的文件夹视图中显示电子邮件的标记，或者例如向发送者发送确认电子邮件消息。 也可以通过电子邮件投票。

公开(公告)号：US20070125712A1

公开(公告)日：2007-06-07

申请号：US11564951

申请日：2006-11-30

申请人： Charles Little ,  Barry Haymore

发明人： Charles Little ,  Barry Haymore

IPC分类号： B01D15/08

CPC分类号： B01D15/422 ,  B01D15/363 ,  C07C309/11 ,  C07C309/32 ,  C07C309/39 ,  C07C309/42 ,  C07C309/58 ,  C07C309/60 ,  C07C2603/26 ,  C07D251/70 ,  C07D263/57

摘要： A displacement chromatography process, including: loading onto a stationary phase comprising an anion-exchange material a mixture comprising one or more component to be separated; displacing at least one of the one or more component from the stationary phase by applying to the stationary phase a mixture comprising an polyaromatic polyanionic displacer compound having a general formula Cen (Ar)w, in which Cen is a central bond or group, Ar is an aromatic nucleus, w=2 to the maximum number of sites one Cen, and Ar is substituted with a plurality of An−, in which each An− is independently defined as sulfonate, carboxylate, phosphonate, phosphate, sulfate; and Ar is further substituted with a plurality of G, in which G is defined as independently H, C1-C6 alkyl, halogen, nitro, hydroxy, C1-C6 alkoxy In addition, a group of polyaromatic polyanionic displacer compounds useful in the process is disclosed.

摘要翻译： 一种置换色谱方法，包括：将包含一种或多种待分离组分的混合物的包含阴离子交换材料的固定相载入; 通过向固定相施加包含具有通式Cen（Ar）W的多芳族聚阴离子置换剂化合物的混合物，将来自固定相的一种或多种组分中的至少一种组分置换，其中Cen为 中心键或基团，Ar是芳香核，w = 2，最大数目为1个Cen，Ar被多个An取代，其中每个An < / SUP>独立地定义为磺酸盐，羧酸盐，膦酸盐，磷酸盐，硫酸盐; 并且Ar进一步被多个G取代，其中G独立地被定义为C 1 -C 6烷基，卤素，硝基，羟基，C > 1 -C 6烷氧基另外，公开了一种在该方法中有用的一种多芳族聚阴离子置换剂化合物。

公开(公告)号：US20070102363A1

公开(公告)日：2007-05-10

申请号：US11551765

申请日：2006-10-23

申请人： Charles Little ,  Victor van de Pas ,  Barry Haymore

发明人： Charles Little ,  Victor van de Pas ,  Barry Haymore

IPC分类号： B01D15/08

CPC分类号： B01D15/422 ,  C08G73/0226 ,  G01N30/96

摘要： A displacement chromatography process and displacer compounds used in the process and having the general formula (I): wherein: each group R1, R2, R3, R′1, R′2, and R′3, independently may be selected from alkyl, aryl, and aralkyl, and in which a ring containing one or more quaternary nitrogen may be formed by any one or more of R1 and R2, R1 and R′1, R1 and R4, R4 and R′4, or R4 and R5; each R4, R′4, R5 and R′5 independently may be selected from alkyl, aryl, aralkyl and —(CH2)a—(CHY)b—(CH2)c—N+R1R2R3 An−, wherein R1, R2 and R3 are as defined above; each Y independently may be selected from —H, —OH, —OR6, halo, alkyl, aryl and aralkyl, wherein —R6 may be alkyl or —(CH2)a—(CHOH)b—(CH2)c—N+R1R2R3 An−, wherein R1, R2 and R3 are as defined above; each q and z independently may be any whole number from 0 to about 6, with the proviso that q+z is equal to or less than about 6; each a, b, and c independently may be any whole number from 0 to 2, with the proviso that the sum a+b+c in any fragment is at least 1; and each An− independently may be one or more organic or inorganic, monovalent or polyvalent anion as needed to obtain a neutral compound.