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    Elliptical step distance measurement
    3.
    发明申请
    Elliptical step distance measurement 有权
    椭圆步距测量

    公开(公告)号：US20050209056A1

    公开(公告)日：2005-09-22

    申请号：US10787788

    申请日：2004-02-26

    申请人： Juliette Daly ,  John Rogus ,  John Hsing ,  Gregory Joseph

    发明人： Juliette Daly ,  John Rogus ,  John Hsing ,  Gregory Joseph

    IPC分类号： A63B22/04 ,  A63B23/04 ,  A63B24/00 ,  A63B71/00

    CPC分类号： A63B22/001 ,  A63B22/0017 ,  A63B22/0664 ,  A63B24/00 ,  A63B2022/002 ,  A63B2022/067 ,  A63B2220/34

    摘要： In an elliptical step exercise apparatus distance traveled can be approximated by determining the portion of the ellipse traversed by a foot pedal where the user applies force to the pedal. This portion can be considered equivalent to the amount of foot travel on a treadmill and modified as a function of speed to simulate the gait of a user at various speeds so as to provide an approximation of the distance traveled by a user as if he were running on a treadmill. This process can be further modified for use with an elliptical exercise apparatus where the stride length can be changed such that the simulated distance will be increased with increased stride length.

    摘要翻译： 在椭圆台阶锻炼装置中，行进距离可以通过确定由脚踏板穿过的椭圆的部分来近似，其中用户向踏板施加力。 该部分可以被认为等同于在跑步机上的行走量，并根据速度进行修改，以模拟用户各种速度的步态，以便提供用户近似行进的距离，就好像他正在跑步 在跑步机上 该过程可以进一步修改以用于可以改变步幅长度的椭圆运动装置，使得模拟距离将随着步幅长度的增加而增加。

    Method and Kit for Determining Severity and Progression of Periodontal Disease
    4.
    发明申请
    Method and Kit for Determining Severity and Progression of Periodontal Disease 审中-公开
    确定牙周病严重程度和进展的方法和试剂盒

    公开(公告)号：US20120208187A1

    公开(公告)日：2012-08-16

    申请号：US13316198

    申请日：2011-12-09

    申请人： Kenneth Kornman ,  Xiaodong Wu ,  Hwa-Ying Wang ,  Steven Offenbacher ,  James Beck ,  John Rogus

    发明人： Kenneth Kornman ,  Xiaodong Wu ,  Hwa-Ying Wang ,  Steven Offenbacher ,  James Beck ,  John Rogus

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q1/6827 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/172 ,  G01N2800/18

    摘要： An improved method and kit of determining whether a patient is predisposed to having severe periodontal disease and/or having high risk of progression of periodontal disease, comprising the steps of (i) taking a biological sample from said patient; (ii) genotyping said biological sample for genetic polymorphism pattern comprising IL 1B (rs16944), IL 1B (rs1143623) and IL 1B (rs4848306); and (iii) comparing said genetic polymorphism patterns to a reference composite genotype pattern; wherein the similarity of said genetic polymorphism patterns to said reference pattern indicate said patient's predisposition to having severe periodontal disease and/or having high risk of progression of periodontal disease.

    摘要翻译： 一种改进的方法和试剂盒，用于确定患者是否倾向于具有严重的牙周疾病和/或具有高风险的牙周病，包括以下步骤：（i）从所述患者取得生物样品; （ii）对包含IL 1B（rs16944），IL 1B（rs1143623）和IL 1B（rs4848306）的遗传多态性模式的所述生物样品进行基因分型; 和（iii）将所述遗传多态性模式与参考复合基因型模式进行比较; 其中所述遗传多态性模式与所述参考模式的相似性指示所述患者患有严重牙周疾病和/或具有高牙周病进展风险的倾向。

    IL-1 Gene Cluster and Associated Inflammatory Polymorphisms and Haplotypes
    5.
    发明申请
    IL-1 Gene Cluster and Associated Inflammatory Polymorphisms and Haplotypes 有权
    IL-1基因簇和相关炎症多态性和单倍型

    公开(公告)号：US20090298063A1

    公开(公告)日：2009-12-03

    申请号：US12084181

    申请日：2006-10-25

    申请人： Kenneth S. Kornman ,  Kenneth Huttner ,  John Rogus

    发明人： Kenneth S. Kornman ,  Kenneth Huttner ,  John Rogus

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

    摘要： The invention provides methods and compositions relating to identification and use of genetic information from the IL-1 gene cluster—including the structure and organization of novel IL-1-like genes found within the IL-1 locus as well as polymorphisms and associated haplotypes within these genes. The invention thereby expands the repertoire of useful genetic information available from the IL-1 locus—which contains the previously-identified IL-1α, EL-1β and IL-1RN genes, for predicting IL-1 associated phenotypes (e.g. increased or decreased risks of inflammatory disease) and for treating IL-1 haplotype associated inflammatory phenotypes.

    摘要翻译： 本发明提供了与IL-1基因簇的遗传信息的鉴定和使用有关的方法和组合，包括在IL-1基因座内发现的新型IL-1样基因的结构和组织以及多态性和相关单体型 这些基因。 因此，本发明扩展了可用于预测IL-1相关表型的IL-1基因座（其含有先前鉴定的IL-1α，EL-1β和IL-1RN基因）的有用遗传信息的所有组成成分（例如增加或减少的风险 的炎性疾病）和用于治疗IL-1单倍型相关的炎症表型。

    IL-GENE CLUSTER AND ASSOCIATED INFLAMMATORY POLYMORPHISMS AND HAPLOTYPES
    7.
    发明申请
    IL-GENE CLUSTER AND ASSOCIATED INFLAMMATORY POLYMORPHISMS AND HAPLOTYPES 审中-公开
    白介素基因簇和相关炎症多态性和嗜酸性粒细胞

    公开(公告)号：US20080254478A1

    公开(公告)日：2008-10-16

    申请号：US12139139

    申请日：2008-06-13

    申请人： Kenneth KORNMAN ,  Ken Huttner ,  John Rogus

    发明人： Kenneth KORNMAN ,  Ken Huttner ,  John Rogus

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/172

    摘要： The invention provides methods and compositions relating to identification and use of genetic information from the IL-1 gene cluster—including the structure and organization of novel IL-1-like genes found within the IL-1 locus as well as polymorphisms and associated haplotypes within these genes. The invention thereby expands the repertoire of useful genetic information available from the IL-1 locus—which contains the previously-identified IL-1α, IL-1β and IL-1RN genes, for predicting IL-1 associated phenotypes (e.g. increased or decreased risks of inflammatory disease) and for treating IL-1 haplotype associated inflammatory phenotypes.

    摘要翻译： 本发明提供了与IL-1基因簇的遗传信息的鉴定和使用有关的方法和组合，包括在IL-1基因座内发现的新型IL-1样基因的结构和组织以及多态性和相关单体型 这些基因。 因此，本发明扩展了可用于预测IL-1相关表型的IL-1基因座（其含有先前鉴定的IL-1α，IL-1β和IL-1RN基因）的有用遗传信息的所有组成成分（例如增加或减少的风险 的炎性疾病）和用于治疗IL-1单倍型相关的炎症表型。

    IL-1 GENE CLUSTER AND ASSOCIATED INFLAMMATORY POLYMORPHISMS AND HAPLOTYPES
    8.
    发明申请
    IL-1 GENE CLUSTER AND ASSOCIATED INFLAMMATORY POLYMORPHISMS AND HAPLOTYPES 审中-公开

    公开(公告)号：US20080254477A1

    公开(公告)日：2008-10-16

    申请号：US12139069

    申请日：2008-06-13

    申请人： Kenneth KORNMAN ,  Ken Huttner ,  John Rogus

    发明人： Kenneth KORNMAN ,  Ken Huttner ,  John Rogus

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/172

    摘要： The invention provides methods and compositions relating to identification and use of genetic information from the IL-1 gene cluster—including the structure and organization of novel IL-1-like genes found within the IL-1 locus as well as polymorphisms and associated haplotypes within these genes. The invention thereby expands the repertoire of useful genetic information available from the IL-1 locus—which contains the previously-identified IL-1α, IL-1β and IL-1RN genes, for predicting IL-1 associated phenotypes (e.g. increased or decreased risks of inflammatory disease) and for treating IL-1 haplotype associated inflammatory phenotypes.

    Elliptical step mechanism
    9.
    发明申请
    Elliptical step mechanism 审中-公开
    椭圆步机制

    公开(公告)号：US20060189446A1

    公开(公告)日：2006-08-24

    申请号：US11338788

    申请日：2006-01-25

    申请人： John Rogus

    发明人： John Rogus

    IPC分类号： A63B22/04 ,  A63B22/06

    CPC分类号： A63B22/001 ,  A63B22/0015 ,  A63B22/0664 ,  A63B24/00 ,  A63B2022/002 ,  A63B2022/067

    摘要： In an exercise apparatus that includes a frame that is adapted for placement on the floor, a pivot axle supported by the frame, a pedal lever and a pedal, a mechanism is provided that allows the pedal to be selectively moved by a user relative to the pedal lever in order to produce a variety of elliptical paths. As a result, by varying the pedal position relative to the pedal lever, the corresponding elliptical path of the pedal can be changed, for example, relative to a fixed, horizontal plane, such as the floor, to simulate an uphill, horizontal or downhill gait.

    摘要翻译： 在包括适于放置在地板上的框架的运动装置中，由框架支撑的枢轴，踏板杆和踏板提供了一种机构，其允许踏板相对于使用者选择性地移动 踏板杆为了产生各种椭圆形路径。 结果，通过相对于踏板杆改变踏板位置，可以例如相对于诸如地板的固定的水平平面来改变踏板的相应椭圆形路径，以模拟上坡，水平或下坡 步态。

    IL-1 gene cluster and associated inflammatory polymorphisms and haplotypes
    10.
    发明授权
    IL-1 gene cluster and associated inflammatory polymorphisms and haplotypes 有权
    IL-1基因簇和相关的炎症多态性和单倍型

    公开(公告)号：US08105775B2

    公开(公告)日：2012-01-31

    申请号：US12084181

    申请日：2006-10-25

    申请人： Kenneth S. Kornman ,  Kenneth Huttner ,  John Rogus

    发明人： Kenneth S. Kornman ,  Kenneth Huttner ,  John Rogus

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

    摘要： The invention provides methods and compositions relating to identification and use of genetic information from the IL-I gene cluster—including the structure and organization of novel IL-I-like genes found within the IL-I locus as well as polymorphisms and associated haplotypes within these genes. The invention thereby expands the repertoire of useful genetic information available from the IL-I locus—which contains the previously-identified IL-1α, EL-1β and IL-IRN genes, for predicting IL-I associated phenotypes (e.g. increased or decreased risks of inflammatory disease) and for treating IL-I haplotype associated inflammatory phenotypes.

    摘要翻译： 本发明提供了关于识别和使用来自IL-1基因簇的遗传信息的方法和组合物，包括在IL-1基因座内发现的新型IL-1样基因的结构和组织以及多态性和相关单体型 这些基因。 因此，本发明扩展了可从IL-1基因座获得的有用遗传信息的所有组成成分，其含有先前鉴定的IL-1α，EL-1和bgr; 和IL-1RN基因，用于预测IL-1相关表型（例如增加或减少的炎性疾病的风险）和用于治疗IL-1单倍型相关的炎症表型。