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21 条记录 (耗时 0.037 秒)

    IL-1 Gene Cluster and Associated Inflammatory Polymorphisms and Haplotypes
    1.
    发明申请
    IL-1 Gene Cluster and Associated Inflammatory Polymorphisms and Haplotypes 有权
    IL-1基因簇和相关炎症多态性和单倍型

    公开(公告)号：US20090298063A1

    公开(公告)日：2009-12-03

    申请号：US12084181

    申请日：2006-10-25

    申请人： Kenneth S. Kornman ,  Kenneth Huttner ,  John Rogus

    发明人： Kenneth S. Kornman ,  Kenneth Huttner ,  John Rogus

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

    摘要： The invention provides methods and compositions relating to identification and use of genetic information from the IL-1 gene cluster—including the structure and organization of novel IL-1-like genes found within the IL-1 locus as well as polymorphisms and associated haplotypes within these genes. The invention thereby expands the repertoire of useful genetic information available from the IL-1 locus—which contains the previously-identified IL-1α, EL-1β and IL-1RN genes, for predicting IL-1 associated phenotypes (e.g. increased or decreased risks of inflammatory disease) and for treating IL-1 haplotype associated inflammatory phenotypes.

    摘要翻译： 本发明提供了与IL-1基因簇的遗传信息的鉴定和使用有关的方法和组合，包括在IL-1基因座内发现的新型IL-1样基因的结构和组织以及多态性和相关单体型 这些基因。 因此，本发明扩展了可用于预测IL-1相关表型的IL-1基因座（其含有先前鉴定的IL-1α，EL-1β和IL-1RN基因）的有用遗传信息的所有组成成分（例如增加或减少的风险 的炎性疾病）和用于治疗IL-1单倍型相关的炎症表型。

    IL-1 gene cluster and associated inflammatory polymorphisms and haplotypes
    3.
    发明授权
    IL-1 gene cluster and associated inflammatory polymorphisms and haplotypes 有权
    IL-1基因簇和相关的炎症多态性和单倍型

    公开(公告)号：US08105775B2

    公开(公告)日：2012-01-31

    申请号：US12084181

    申请日：2006-10-25

    申请人： Kenneth S. Kornman ,  Kenneth Huttner ,  John Rogus

    发明人： Kenneth S. Kornman ,  Kenneth Huttner ,  John Rogus

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

    摘要： The invention provides methods and compositions relating to identification and use of genetic information from the IL-I gene cluster—including the structure and organization of novel IL-I-like genes found within the IL-I locus as well as polymorphisms and associated haplotypes within these genes. The invention thereby expands the repertoire of useful genetic information available from the IL-I locus—which contains the previously-identified IL-1α, EL-1β and IL-IRN genes, for predicting IL-I associated phenotypes (e.g. increased or decreased risks of inflammatory disease) and for treating IL-I haplotype associated inflammatory phenotypes.

    摘要翻译： 本发明提供了关于识别和使用来自IL-1基因簇的遗传信息的方法和组合物，包括在IL-1基因座内发现的新型IL-1样基因的结构和组织以及多态性和相关单体型 这些基因。 因此，本发明扩展了可从IL-1基因座获得的有用遗传信息的所有组成成分，其含有先前鉴定的IL-1α，EL-1和bgr; 和IL-1RN基因，用于预测IL-1相关表型（例如增加或减少的炎性疾病的风险）和用于治疗IL-1单倍型相关的炎症表型。

    IL-1 gene cluster, insulin resistance and coronary artery disease associated polymorphisms and haplotypes and methods of using same
    4.
    发明授权
    IL-1 gene cluster, insulin resistance and coronary artery disease associated polymorphisms and haplotypes and methods of using same 有权
    IL-1基因簇，胰岛素抵抗和冠状动脉疾病相关多态性和单元型及其使用方法

    公开(公告)号：US08101360B2

    公开(公告)日：2012-01-24

    申请号：US11985614

    申请日：2007-11-15

    申请人： Kenneth S. Kornman ,  Kenneth Huttner

    发明人： Kenneth S. Kornman ,  Kenneth Huttner

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/04

    CPC分类号： C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

    摘要： The invention provides methods and compositions relating to identification and use of genetic information from the IL-1 gene cluster—including the structure and organization of novel IL-1-like genes found within the IL-1 locus as well as polymorphisms and associated haplotypes within these genes. The invention thereby expands the repertoire of useful genetic information available from the IL-1 locus—which contains the previously-identified IL-1α, IL-1β and IL-1RN genes, for predicting IL-1 associated phenotypes (e.g. increased or decreased risks of insulin resistance associated pathologies) and for treating IL-1 haplotype associated insulin resistance associated pathologies.

    摘要翻译： 本发明提供了与IL-1基因簇的遗传信息的鉴定和使用有关的方法和组合，包括在IL-1基因座内发现的新型IL-1样基因的结构和组织以及多态性和相关单体型 这些基因。 本发明从而扩展了可用于IL-1基因座的有用的遗传信息，其含有先前鉴定的IL-1α，IL-1和bgr; 和IL-1RN基因，用于预测IL-1相关表型（例如增加或降低胰岛素抵抗相关病理学的风险）和用于治疗IL-1单倍型相关的胰岛素抵抗相关病理学。

    IL-1 gene cluster, insulin resistance and coronary artery disease associated polymorphisms and haplotypes and methods of using same
    5.
    发明申请
    IL-1 gene cluster, insulin resistance and coronary artery disease associated polymorphisms and haplotypes and methods of using same 有权
    IL-1基因簇，胰岛素抵抗和冠状动脉疾病相关多态性和单元型及其使用方法

    公开(公告)号：US20090098141A1

    公开(公告)日：2009-04-16

    申请号：US11985614

    申请日：2007-11-15

    申请人： Kenneth S. Kornman ,  Kenneth Huttner

    发明人： Kenneth S. Kornman ,  Kenneth Huttner

    IPC分类号： A61K39/395 ,  C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

    摘要： The invention provides methods and compositions relating to identification and use of genetic information from the IL-1 gene cluster—including the structure and organization of novel IL-1-like genes found within the IL-1 locus as well as polymorphisms and associated haplotypes within these genes. The invention thereby expands the repertoire of useful genetic information available from the IL-1 locus—which contains the previously-identified IL-1α, IL-1β and IL-1RN genes, for predicting IL-1 associated phenotypes (e.g. increased or decreased risks of insulin resistance associated pathologies) and for treating IL-1 haplotype associated insulin resistance associated pathologies.

    摘要翻译： 本发明提供了与IL-1基因簇的遗传信息的鉴定和使用有关的方法和组合，包括在IL-1基因座内发现的新型IL-1样基因的结构和组织以及多态性和相关单体型 这些基因。 因此，本发明扩展了可用于预测IL-1相关表型的IL-1基因座（其含有先前鉴定的IL-1α，IL-1β和IL-1RN基因）的有用遗传信息的所有组成成分（例如增加或减少的风险 的胰岛素抵抗相关病理）和用于治疗IL-1单倍型相关的胰岛素抵抗相关病理学。

    SYSTEM FOR PROVIDING ANONYMOUS ACCESS TO HEALTH INFORMATION
    7.
    发明申请
    SYSTEM FOR PROVIDING ANONYMOUS ACCESS TO HEALTH INFORMATION 审中-公开
    提供健康信息获取的系统

    公开(公告)号：US20090216559A1

    公开(公告)日：2009-08-27

    申请号：US12367272

    申请日：2009-02-06

    申请人： David W. Krempin ,  Kenneth S. Kornman ,  Russell K. Randolph ,  Haeri Roh-Schmidt

    发明人： David W. Krempin ,  Kenneth S. Kornman ,  Russell K. Randolph ,  Haeri Roh-Schmidt

    IPC分类号： G06Q50/00 ,  G06F17/30 ,  G06F17/40

    CPC分类号： G06Q50/24 ,  G16H10/20 ,  G16H50/70 ,  Y02A90/22 ,  Y02A90/26

    摘要： A system for providing anonymous access to health information may include an interface, a memory and a web portal. The interface may be operative to receive a test result of a biological sample of an individual and a unique identifier associated with the test result. The individual may not be identifiable by the unique identifier. The memory may be operative to store a record in a database. The record may include the test result and the unique identifier associated with the test result. The web portal may be coupled with the database and may be operative to receive the unique identifier from a user. The web portal may retrieve the record comprising of the unique identifier, and display the test result stored in the record to the user.

    摘要翻译： 用于提供对健康信息的匿名访问的系统可以包括接口，存储器和web门户。 接口可以操作以接收个体的生物样品的测试结果和与测试结果相关联的唯一标识符。 个人可能无法通过唯一标识符来识别。 存储器可以用于将数据库中的记录存储起来。 记录可以包括测试结果和与测试结果相关联的唯一标识符。 网络门户可以与数据库耦合，并且可以用于从用户接收唯一的标识符。 门户网站可以检索包含唯一标识符的记录，并将存储在记录中的测试结果显示给用户。

    Diagnostics for Aging-Related Dermatologic Disorders
    8.
    发明申请
    Diagnostics for Aging-Related Dermatologic Disorders 审中-公开
    老年相关皮肤病障碍诊断

    公开(公告)号：US20090170105A1

    公开(公告)日：2009-07-02

    申请号：US12268233

    申请日：2008-11-10

    申请人： Kenneth S. Kornman ,  Leon Wilkins

    发明人： Kenneth S. Kornman ,  Leon Wilkins

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/172

    摘要： The present invention provides methods for the early prediction of aging-related dermatologic conditions of including skin changes associated with intrinsic aging or skin damages caused by extrinsic aging such as photoaging. The present invention also provides kits for the early determination of the propensity to develop such disorder and conditions. The method consists of detecting the presence of one or more alleles of an IL-1 haplotype or pattern, specifically the IL-1RN (+2018) and the IL-1B (−511) loci. The presence of allele 2 at the IL-1RN (+2018) and the IL-1B (−511) loci indicates decreased risk for a early onset of aging related dermatologic conditions.

    摘要翻译： 本发明提供了用于早期预测老化相关皮肤病学条件的方法，其包括与内在衰老相关的皮肤变化或由诸如光老化的外在老化引起的皮肤损伤。 本发明还提供用于早期确定发展这种病症和病症的倾向的试剂盒。 该方法包括检测IL-1单倍型或模式，特别是IL-1RN（+2018）和IL-1B（-511）基因座的一个或多个等位基因的存在。 在IL-1RN（+2018）和IL-1B（-511）位点处的等位基因2的存在表明衰老相关皮肤病学早期发病风险降低。

    Integrated disease information system
    10.
    发明授权
    Integrated disease information system 失效
    综合疾病信息系统

    公开(公告)号：US6108635A

    公开(公告)日：2000-08-22

    申请号：US858200

    申请日：1997-04-30

    申请人： L. Tandy Herren ,  Pamela K. Fink ,  Kenneth S. Kornman ,  Christopher J. Moehle ,  Debra J. Moore

    发明人： L. Tandy Herren ,  Pamela K. Fink ,  Kenneth S. Kornman ,  Christopher J. Moehle ,  Debra J. Moore

    IPC分类号： G06F19/00 ,  G06F17/60

    CPC分类号： G06F19/363 ,  G06F19/322 ,  G06F19/3406 ,  G06Q40/08 ,  G06Q50/22 ,  G06Q50/24 ,  G06F19/324 ,  G06F19/328 ,  G06F19/3456

    摘要： A system including a set of software based Explorers, and a computer assisted methodology support the development of new medical interventions for diseases. The system includes Explorer modules for discovering proposed interventions, designing clinical trials, performing pharmacoeconomic analysis, and illustrating disease progression for various patients over time including creating disease progression tutorials for patients. The Explorers support a bottom-up or data driven methodology that enables a user, such as medical researcher, to mine data sources of clinical, biologic, expert or other types of data to discover, test, evaluate, and understand a proposed intervention and its impact on disease progression in different patient types. A Target Discovery Explorer assists the user in identifying leverage points in disease progression in relationship to various patient attributes and interventions, thereby identifying a proposed intervention for the desease. A Clinical Trials Explorer assists the user in designing clinical trials based through identification of combinations of patient attributes and intervention attributes that yield efficacious changes in selected disease progression measures. A Pharmacoeconomic Explorer enables the user to determine relative costs-benefits of a proposed intervention for patients, practitioners, and payers, including quality of life results for patients, practice results for practitioners, and financial payment results for payers. A Disease Progression Explorer enables the user to visually project disease progression for specified patient attributes and interventions, in order to better understand and explain the effects of an intervention on a disease for such patients and their practitioners, and to select disease progression tutorials that are directed to the specific patient attributes and their corresponding effect on disease progression over time.

    摘要翻译： 包括一套基于软件的探索者的系统和计算机辅助的方法支持开发新的疾病医疗干预措施。 该系统包括用于发现拟议干预措施的资源管理器模块，设计临床试验，进行药物经济学分析，并说明不同患者随时间的疾病进展，包括为病人制定疾病进展教程。 探索者支持自下而上或数据驱动的方法，使用户（如医学研究员）能够挖掘临床，生物学，专家或其他类型数据的数据来源，以发现，测试，评估和了解拟议的干预措施及其 对不同患者类型疾病进展的影响。 目标发现浏览器可帮助用户识别与各种患者属性和干预相关的疾病进展中的杠杆点，从而确定拟议的疾病干预。 临床试验探索者通过识别患者属性和干预属性的组合来帮助用户设计临床试验，从而在选定的疾病进展措施中产生有效的变化。 药物经济探索者使用户能够确定针对患者，从业者和付款人的拟议干预措施的相对成本效益，包括患者的生活质量结果，从业人员的实践结果以及付款人的财务支付结果。 疾病进展探查者使用户可以直观地预测特定患者属性和干预的疾病进展情况，以便更好地了解和解释干预对这种患者及其从业者的疾病的影响，并选择指导的疾病进展教程 具体患者属性及其对疾病进展的相应影响。