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    IL-1 Gene Cluster and Associated Inflammatory Polymorphisms and Haplotypes
    1.
    发明申请
    IL-1 Gene Cluster and Associated Inflammatory Polymorphisms and Haplotypes 有权
    IL-1基因簇和相关炎症多态性和单倍型

    公开(公告)号：US20090298063A1

    公开(公告)日：2009-12-03

    申请号：US12084181

    申请日：2006-10-25

    申请人： Kenneth S. Kornman ,  Kenneth Huttner ,  John Rogus

    发明人： Kenneth S. Kornman ,  Kenneth Huttner ,  John Rogus

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

    摘要： The invention provides methods and compositions relating to identification and use of genetic information from the IL-1 gene cluster—including the structure and organization of novel IL-1-like genes found within the IL-1 locus as well as polymorphisms and associated haplotypes within these genes. The invention thereby expands the repertoire of useful genetic information available from the IL-1 locus—which contains the previously-identified IL-1α, EL-1β and IL-1RN genes, for predicting IL-1 associated phenotypes (e.g. increased or decreased risks of inflammatory disease) and for treating IL-1 haplotype associated inflammatory phenotypes.

    摘要翻译： 本发明提供了与IL-1基因簇的遗传信息的鉴定和使用有关的方法和组合，包括在IL-1基因座内发现的新型IL-1样基因的结构和组织以及多态性和相关单体型 这些基因。 因此，本发明扩展了可用于预测IL-1相关表型的IL-1基因座（其含有先前鉴定的IL-1α，EL-1β和IL-1RN基因）的有用遗传信息的所有组成成分（例如增加或减少的风险 的炎性疾病）和用于治疗IL-1单倍型相关的炎症表型。

    IL-1 gene cluster and associated inflammatory polymorphisms and haplotypes
    2.
    发明授权
    IL-1 gene cluster and associated inflammatory polymorphisms and haplotypes 有权
    IL-1基因簇和相关的炎症多态性和单倍型

    公开(公告)号：US08105775B2

    公开(公告)日：2012-01-31

    申请号：US12084181

    申请日：2006-10-25

    申请人： Kenneth S. Kornman ,  Kenneth Huttner ,  John Rogus

    发明人： Kenneth S. Kornman ,  Kenneth Huttner ,  John Rogus

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

    摘要： The invention provides methods and compositions relating to identification and use of genetic information from the IL-I gene cluster—including the structure and organization of novel IL-I-like genes found within the IL-I locus as well as polymorphisms and associated haplotypes within these genes. The invention thereby expands the repertoire of useful genetic information available from the IL-I locus—which contains the previously-identified IL-1α, EL-1β and IL-IRN genes, for predicting IL-I associated phenotypes (e.g. increased or decreased risks of inflammatory disease) and for treating IL-I haplotype associated inflammatory phenotypes.

    摘要翻译： 本发明提供了关于识别和使用来自IL-1基因簇的遗传信息的方法和组合物，包括在IL-1基因座内发现的新型IL-1样基因的结构和组织以及多态性和相关单体型 这些基因。 因此，本发明扩展了可从IL-1基因座获得的有用遗传信息的所有组成成分，其含有先前鉴定的IL-1α，EL-1和bgr; 和IL-1RN基因，用于预测IL-1相关表型（例如增加或减少的炎性疾病的风险）和用于治疗IL-1单倍型相关的炎症表型。

    IL-1 gene cluster, insulin resistance and coronary artery disease associated polymorphisms and haplotypes and methods of using same
    4.
    发明授权
    IL-1 gene cluster, insulin resistance and coronary artery disease associated polymorphisms and haplotypes and methods of using same 有权
    IL-1基因簇，胰岛素抵抗和冠状动脉疾病相关多态性和单元型及其使用方法

    公开(公告)号：US08101360B2

    公开(公告)日：2012-01-24

    申请号：US11985614

    申请日：2007-11-15

    申请人： Kenneth S. Kornman ,  Kenneth Huttner

    发明人： Kenneth S. Kornman ,  Kenneth Huttner

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/04

    CPC分类号： C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

    摘要： The invention provides methods and compositions relating to identification and use of genetic information from the IL-1 gene cluster—including the structure and organization of novel IL-1-like genes found within the IL-1 locus as well as polymorphisms and associated haplotypes within these genes. The invention thereby expands the repertoire of useful genetic information available from the IL-1 locus—which contains the previously-identified IL-1α, IL-1β and IL-1RN genes, for predicting IL-1 associated phenotypes (e.g. increased or decreased risks of insulin resistance associated pathologies) and for treating IL-1 haplotype associated insulin resistance associated pathologies.

    摘要翻译： 本发明提供了与IL-1基因簇的遗传信息的鉴定和使用有关的方法和组合，包括在IL-1基因座内发现的新型IL-1样基因的结构和组织以及多态性和相关单体型 这些基因。 本发明从而扩展了可用于IL-1基因座的有用的遗传信息，其含有先前鉴定的IL-1α，IL-1和bgr; 和IL-1RN基因，用于预测IL-1相关表型（例如增加或降低胰岛素抵抗相关病理学的风险）和用于治疗IL-1单倍型相关的胰岛素抵抗相关病理学。

    IL-1 gene cluster, insulin resistance and coronary artery disease associated polymorphisms and haplotypes and methods of using same
    5.
    发明申请
    IL-1 gene cluster, insulin resistance and coronary artery disease associated polymorphisms and haplotypes and methods of using same 有权
    IL-1基因簇，胰岛素抵抗和冠状动脉疾病相关多态性和单元型及其使用方法

    公开(公告)号：US20090098141A1

    公开(公告)日：2009-04-16

    申请号：US11985614

    申请日：2007-11-15

    申请人： Kenneth S. Kornman ,  Kenneth Huttner

    发明人： Kenneth S. Kornman ,  Kenneth Huttner

    IPC分类号： A61K39/395 ,  C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

    摘要： The invention provides methods and compositions relating to identification and use of genetic information from the IL-1 gene cluster—including the structure and organization of novel IL-1-like genes found within the IL-1 locus as well as polymorphisms and associated haplotypes within these genes. The invention thereby expands the repertoire of useful genetic information available from the IL-1 locus—which contains the previously-identified IL-1α, IL-1β and IL-1RN genes, for predicting IL-1 associated phenotypes (e.g. increased or decreased risks of insulin resistance associated pathologies) and for treating IL-1 haplotype associated insulin resistance associated pathologies.

    摘要翻译： 本发明提供了与IL-1基因簇的遗传信息的鉴定和使用有关的方法和组合，包括在IL-1基因座内发现的新型IL-1样基因的结构和组织以及多态性和相关单体型 这些基因。 因此，本发明扩展了可用于预测IL-1相关表型的IL-1基因座（其含有先前鉴定的IL-1α，IL-1β和IL-1RN基因）的有用遗传信息的所有组成成分（例如增加或减少的风险 的胰岛素抵抗相关病理）和用于治疗IL-1单倍型相关的胰岛素抵抗相关病理学。