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公开(公告)号：US20110244514A1
公开(公告)日：2011-10-06
申请号：US12721463
申请日：2010-03-10
申请人： Charles S. Zuker , Nicholas J.P. Ryba , Gregory A. Nelson , Mark A. Hoon , Jayaram Chandrashekar , Yifeng Zhang
发明人： Charles S. Zuker , Nicholas J.P. Ryba , Gregory A. Nelson , Mark A. Hoon , Jayaram Chandrashekar , Yifeng Zhang
CPC分类号： C07K14/705
摘要： The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.
摘要翻译： 本发明提供了包含来自感官G蛋白偶联受体的T1R家族的两种异源G蛋白偶联受体多肽，这种受体的抗体，检测这种核酸和受体的方法的甜味受体的分离的核酸和氨基酸序列， 以及筛选甜味受体调节剂的方法。
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公开(公告)号：US20090098580A1
公开(公告)日：2009-04-16
申请号：US12147415
申请日：2008-06-26
申请人： Charles S. Zuker , Nicholas J.P. Ryba , Gregory A. Nelson , Mark A. Hoon , Jayaram Chandrashekar , Yifeng Zhang
发明人： Charles S. Zuker , Nicholas J.P. Ryba , Gregory A. Nelson , Mark A. Hoon , Jayaram Chandrashekar , Yifeng Zhang
CPC分类号： C07K14/705
摘要： The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.
摘要翻译： 本发明提供了包含来自感官G蛋白偶联受体的T1R家族的两种异源G蛋白偶联受体多肽，这种受体的抗体，检测这种核酸和受体的方法的甜味受体的分离的核酸和氨基酸序列， 以及筛选甜味受体调节剂的方法。
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公开(公告)号：US20080318251A1
公开(公告)日：2008-12-25
申请号：US12121576
申请日：2008-05-15
申请人： Charles S. Zuker , Jayaram Chandrashekar , Greg Nelson , Yifeng Zhang , Nicholas J.P. Ryba , Mark A. Hoon
发明人： Charles S. Zuker , Jayaram Chandrashekar , Greg Nelson , Yifeng Zhang , Nicholas J.P. Ryba , Mark A. Hoon
IPC分类号： G01N33/566 , C07K14/47 , C12N5/06 , C12N5/08
CPC分类号： G01N33/5076 , C07K14/705
摘要： The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
摘要翻译： 本发明提供了包含来自感觉G蛋白偶联受体的T1R家族的两种异源G蛋白偶联受体多肽的分离的核酸和氨基酸味道受体的氨基酸序列，这些受体的抗体，检测此类核酸的方法 和受体以及筛选甜味和氨基酸味觉受体调节剂的方法。
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公开(公告)号：US07977060B2
公开(公告)日：2011-07-12
申请号：US12147415
申请日：2008-06-26
申请人： Charles S. Zuker , Nicholas J. P. Ryba , Gregory A. Nelson , Mark A. Hoon , Jayaram Chandrashekar , Yifeng Zhang
发明人： Charles S. Zuker , Nicholas J. P. Ryba , Gregory A. Nelson , Mark A. Hoon , Jayaram Chandrashekar , Yifeng Zhang
IPC分类号： C07K14/705 , C12N15/12 , G01N33/566
CPC分类号： C07K14/705
摘要： The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.
摘要翻译： 本发明提供了包含来自感官G蛋白偶联受体的T1R家族的两种异源G蛋白偶联受体多肽，这种受体的抗体，检测这种核酸和受体的方法的甜味受体的分离的核酸和氨基酸序列， 以及筛选甜味受体调节剂的方法。
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公开(公告)号：US07507793B2
公开(公告)日：2009-03-24
申请号：US10645441
申请日：2003-08-20
申请人： Charles S. Zuker , Nicholas J. P. Ryba , Gregory A. Nelson , Mark A. Hoon , Jayaram Chandrashekar , Yifeng Zhang
发明人： Charles S. Zuker , Nicholas J. P. Ryba , Gregory A. Nelson , Mark A. Hoon , Jayaram Chandrashekar , Yifeng Zhang
IPC分类号： C07H21/04 , G01N33/53 , G01N33/567 , C12P21/06 , C07K14/00
CPC分类号： C07K14/705
摘要： The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.
摘要翻译： 本发明提供了包含来自感官G蛋白偶联受体的T1R家族的两种异源G蛋白偶联受体多肽，这种受体的抗体，检测这种核酸和受体的方法的甜味受体的分离的核酸和氨基酸序列， 以及筛选甜味受体调节剂的方法。
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公开(公告)号：US07402400B2
公开(公告)日：2008-07-22
申请号：US09927315
申请日：2001-08-10
申请人： Charles S. Zuker , Nicholas J. P. Ryba , Gregory A. Nelson , Mark A. Hoon , Jayaram Chandrashekar , Yifeng Zhang
发明人： Charles S. Zuker , Nicholas J. P. Ryba , Gregory A. Nelson , Mark A. Hoon , Jayaram Chandrashekar , Yifeng Zhang
IPC分类号： G01N33/566 , C07K14/705
CPC分类号： C07K14/705
摘要： The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.
摘要翻译： 本发明提供了包含来自感官G蛋白偶联受体的T1R家族的两种异源G蛋白偶联受体多肽，这种受体的抗体，检测这种核酸和受体的方法的甜味受体的分离的核酸和氨基酸序列， 以及筛选甜味受体调节剂的方法。
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公开(公告)号：US08198048B2
公开(公告)日：2012-06-12
申请号：US12721463
申请日：2010-03-10
申请人： Charles S. Zuker , Nicholas J. P. Ryba , Gregory A. Nelson , Mark A. Hoon , Jayaram Chandrashekar , Yifeng Zhang
发明人： Charles S. Zuker , Nicholas J. P. Ryba , Gregory A. Nelson , Mark A. Hoon , Jayaram Chandrashekar , Yifeng Zhang
IPC分类号： C12N15/12 , C07K14/705
CPC分类号： C07K14/705
摘要： The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.
摘要翻译： 本发明提供了包含来自感官G蛋白偶联受体的T1R家族的两种异源G蛋白偶联受体多肽，这种受体的抗体，检测这种核酸和受体的方法的甜味受体的分离的核酸和氨基酸序列， 以及筛选甜味受体调节剂的方法。
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8.发明申请Mammalian Sweet and Amino Acid Heterodimeric Taste Receptors Comprising T1R3 and T1R1 有权包含T1R3和T1R1的哺乳动物甜氨基酸异二聚味道感受器公开(公告)号：US20110151483A1
公开(公告)日：2011-06-23
申请号：US12944515
申请日：2010-11-11
申请人： Charles S. Zuker , Jayaram Chandrashekar , Greg Nelson , Yifeng Zhang , Nicholas J. P. Ryba , Mark A. Hoon
发明人： Charles S. Zuker , Jayaram Chandrashekar , Greg Nelson , Yifeng Zhang , Nicholas J. P. Ryba , Mark A. Hoon
CPC分类号： G01N33/5076 , C07K14/705
摘要： The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising T1R3 and T1R1, two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
摘要翻译： 本发明提供了包含T1R3和T1R1的甜或氨基酸味受体的分离的核酸和氨基酸序列，来自感官G蛋白偶联受体的T1R家族的两种异源G蛋白偶联受体多肽，对这种受体的抗体， 检测这种核酸和受体，以及筛选甜味和氨基酸味觉受体调节剂的方法。
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9.发明授权Mammalian sweet and amino acid heterodimeric taste receptors comprising T1R3 and T1R1 有权包含T1R3和T1R1的哺乳动物甜味和氨基酸异二聚体味觉受体公开(公告)号：US08470970B2
公开(公告)日：2013-06-25
申请号：US12944515
申请日：2010-11-11
申请人： Charles S. Zuker , Jayaram Chandrashekar , Greg Nelson , Yifeng Zhang , Nicholas J. P. Ryba , Mark A. Hoon
发明人： Charles S. Zuker , Jayaram Chandrashekar , Greg Nelson , Yifeng Zhang , Nicholas J. P. Ryba , Mark A. Hoon
IPC分类号： C07K14/705 , C07K19/00 , C12N15/62
CPC分类号： G01N33/5076 , C07K14/705
摘要： The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising T1R3 and T1R1, two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
摘要翻译： 本发明提供了包含T1R3和T1R1的甜或氨基酸味受体的分离的核酸和氨基酸序列，来自感官G蛋白偶联受体的T1R家族的两种异源G蛋白偶联受体多肽，对这种受体的抗体， 检测这种核酸和受体，以及筛选甜味和氨基酸味觉受体调节剂的方法。
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公开(公告)号：US20090155819A1
公开(公告)日：2009-06-18
申请号：US12257290
申请日：2008-10-23
IPC分类号： G01N33/53
CPC分类号： C07K14/705 , G01N2333/726
摘要： The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors, the receptors comprising consisting of a monomer or homodimer of a T1R3 G-protein coupled receptor polypeptide, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
摘要翻译： 本发明提供了分离的甜味受体的核酸和氨基酸序列，所述受体包括由T1R3G-蛋白偶联受体多肽的单体或同二聚体组成，对这种受体的抗体，检测此类核酸和受体的方法，以及 筛选甜味和氨基酸味道受体调节剂的方法。
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