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公开(公告)号:US20090155819A1
公开(公告)日:2009-06-18
申请号:US12257290
申请日:2008-10-23
IPC分类号: G01N33/53
CPC分类号: C07K14/705 , G01N2333/726
摘要: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors, the receptors comprising consisting of a monomer or homodimer of a T1R3 G-protein coupled receptor polypeptide, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
摘要翻译: 本发明提供了分离的甜味受体的核酸和氨基酸序列,所述受体包括由T1R3G-蛋白偶联受体多肽的单体或同二聚体组成,对这种受体的抗体,检测此类核酸和受体的方法,以及 筛选甜味和氨基酸味道受体调节剂的方法。
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公开(公告)号:US20080318251A1
公开(公告)日:2008-12-25
申请号:US12121576
申请日:2008-05-15
申请人: Charles S. Zuker , Jayaram Chandrashekar , Greg Nelson , Yifeng Zhang , Nicholas J.P. Ryba , Mark A. Hoon
发明人: Charles S. Zuker , Jayaram Chandrashekar , Greg Nelson , Yifeng Zhang , Nicholas J.P. Ryba , Mark A. Hoon
IPC分类号: G01N33/566 , C07K14/47 , C12N5/06 , C12N5/08
CPC分类号: G01N33/5076 , C07K14/705
摘要: The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
摘要翻译: 本发明提供了包含来自感觉G蛋白偶联受体的T1R家族的两种异源G蛋白偶联受体多肽的分离的核酸和氨基酸味道受体的氨基酸序列,这些受体的抗体,检测此类核酸的方法 和受体以及筛选甜味和氨基酸味觉受体调节剂的方法。
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公开(公告)号:US20110244514A1
公开(公告)日:2011-10-06
申请号:US12721463
申请日:2010-03-10
申请人: Charles S. Zuker , Nicholas J.P. Ryba , Gregory A. Nelson , Mark A. Hoon , Jayaram Chandrashekar , Yifeng Zhang
发明人: Charles S. Zuker , Nicholas J.P. Ryba , Gregory A. Nelson , Mark A. Hoon , Jayaram Chandrashekar , Yifeng Zhang
CPC分类号: C07K14/705
摘要: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.
摘要翻译: 本发明提供了包含来自感官G蛋白偶联受体的T1R家族的两种异源G蛋白偶联受体多肽,这种受体的抗体,检测这种核酸和受体的方法的甜味受体的分离的核酸和氨基酸序列, 以及筛选甜味受体调节剂的方法。
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公开(公告)号:US20090098580A1
公开(公告)日:2009-04-16
申请号:US12147415
申请日:2008-06-26
申请人: Charles S. Zuker , Nicholas J.P. Ryba , Gregory A. Nelson , Mark A. Hoon , Jayaram Chandrashekar , Yifeng Zhang
发明人: Charles S. Zuker , Nicholas J.P. Ryba , Gregory A. Nelson , Mark A. Hoon , Jayaram Chandrashekar , Yifeng Zhang
CPC分类号: C07K14/705
摘要: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.
摘要翻译: 本发明提供了包含来自感官G蛋白偶联受体的T1R家族的两种异源G蛋白偶联受体多肽,这种受体的抗体,检测这种核酸和受体的方法的甜味受体的分离的核酸和氨基酸序列, 以及筛选甜味受体调节剂的方法。
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公开(公告)号:US07465550B2
公开(公告)日:2008-12-16
申请号:US10962365
申请日:2004-10-07
IPC分类号: G01N33/53 , G01N33/567
CPC分类号: G01N33/74 , C07K14/705 , C07K14/723 , C12Q1/025 , G01N33/5041 , G01N33/5044 , G01N33/68 , G01N2333/726
摘要: The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.
摘要翻译: 本发明提供了一种新的味道转导性G蛋白偶联受体家族的核酸和氨基酸序列,这种受体的抗体,检测此类核酸和受体的方法,以及筛选风味转导G蛋白偶联受体调节剂的方法 。
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