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公开(公告)号：US20190105282A1
公开(公告)日：2019-04-11
申请号：US16087746
申请日：2017-03-22
申请人： Che-Ming Jack Hu , Academia Sinica
发明人： Che-Ming Jack Hu , Hui-Wen Chen , Bing-Yu Yao
IPC分类号： A61K9/51 , C12N15/113 , A61K31/708
摘要： A polymeric nanoparticle that has a size of 30-600 nm in outer diameter and contains a polymeric shell, less than 25 nm in thickness and impermeable to water, one or more aqueous cores enclosed by the polymeric shell, and a bioactive agent encapsulated in each of the one or more aqueous cores. Also disclosed are a method of preparing the polymeric nanoparticle and a method of using it for treating a disease.
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公开(公告)号：US11813326B2
公开(公告)日：2023-11-14
申请号：US16959758
申请日：2019-01-03
申请人： ACADEMIA SINICA
CPC分类号： A61K39/39 , A61K9/5153 , A61K2039/55561
摘要： This disclosure provides treatment kit that are capable of modulating the immune response. The treatment kit may also be used enhance the immunogenicity of antigens released from cell debris. Also provided are methods of using the treatment kit.
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公开(公告)号：US20240180845A1
公开(公告)日：2024-06-06
申请号：US18533542
申请日：2023-12-08
申请人： Academia Sinica
发明人： Che-Ming Jack Hu , Hui-Wen Chen , Bing-Yu Yao
IPC分类号： A61K9/51 , A61K31/708 , B82Y5/00 , C12N15/113 , C12N15/87
CPC分类号： A61K9/5153 , A61K9/5192 , A61K31/708 , C12N15/113 , C12N15/87 , B82Y5/00
摘要： A polymeric nanoparticle that has a size of 30-600 nm in outer diameter and contains a polymeric shell, less than 25 nm in thickness and impermeable to water, one or more aqueous cores enclosed by the polymeric shell, and a bioactive agent encapsulated in each of the one or more aqueous cores. Also disclosed are a method of preparing the polymeric nanoparticle and a method of using it for treating a disease.
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公开(公告)号：US20210315966A1
公开(公告)日：2021-10-14
申请号：US17265090
申请日：2019-07-30
申请人： Academia Sinica
发明人： Che-Ming Jack Hu , Yu-Han Liu , Te-Li Chen
摘要： A therapeutic nanoparticle containing a cationic polypeptide and a polyanionic molecule, in which the cationic polypeptide, exerting antibacterial activity, forms electrostatic interaction with the polyanionic molecule, and the therapeutic nanoparticle has a diameter of less than 50 nm. Also disclosed are a pharmaceutical composition, a treatment method, and a preparation method, all related to the therapeutic nanoparticle.
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公开(公告)号：US12109309B2
公开(公告)日：2024-10-08
申请号：US16322014
申请日：2017-07-28
申请人： Academia Sinica
发明人： Che-Ming Jack Hu , Hui-Wen Chen , Yuan-I Chen , Chen-Ying Chien , Jung-Chen Lin
IPC分类号： A61K9/127 , C12N5/078 , G01N33/50 , G01N33/543 , G01N33/556
CPC分类号： A61K9/127 , A61K9/1275 , A61K9/1277 , C12N5/0634 , G01N33/5008 , G01N33/5432 , G01N33/556 , G01N2500/02 , G01N2500/10
摘要： A method of generating an internally fixed lipid vesicle, comprising: providing a precursor lipid vesicle that contains an aqueous interior enclosed by a lipid membrane, wherein the lipid membrane of the precursor lipid vesicle is non-permeable to a crosslinker; permeabilizing the lipid membrane transiently to generate a permeable vesicle; contacting the permeable vesicle with an inactive activatable crosslinker, whereby the inactive activatable crosslinker enters the permeable vesicle; allowing the permeable vesicle to return to a non-permeable vesicle; removing any extravesicular crosslinker; and activating the inactive activatable crosslinker to allow crosslinking to occur inside the non-permeable vesicle, whereby an internally fixed lipid vesicle is generated.
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