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公开(公告)号：US11845729B2
公开(公告)日：2023-12-19
申请号：US17667289
申请日：2022-02-08
申请人： CHEMOCENTRYX, INC.
发明人： Pingchen Fan , Jaroslaw Kalisiak , Antoni Krasinski , Rebecca M. Lui , Jay Powers , Sreenivas Punna , Hiroko Tanaka , Penglie Zhang
IPC分类号： C07D211/60
CPC分类号： C07D211/60
摘要： Intermediates and methods are provided for the preparation of selected C5aR antagonist compounds.
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公开(公告)号：US11433061B2
公开(公告)日：2022-09-06
申请号：US16739204
申请日：2020-01-10
申请人： ChemoCentryx, Inc.
发明人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor T. Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew M. K. Pennell , John J. Wright , Antoni Krasinski , Qiang Wang
IPC分类号： A61K31/444 , C07C311/21 , C07D213/75 , C07D241/22 , C07D401/06 , C07D401/10 , C07D407/04 , C07D409/12 , C07D413/06 , C07D417/12 , C07D471/04 , C07D498/04 , A61K31/437 , A61K31/4439 , A61K45/06
摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.
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公开(公告)号：US10532982B2
公开(公告)日：2020-01-14
申请号：US16360195
申请日：2019-03-21
申请人： CHEMOCENTRYX, INC.
发明人： Pingchen Fan , Jaroslaw Kalisiak , Antoni Krasinski , Rebecca M. Lui , Jay Powers , Sreenivas Punna , Hiroko Tanaka , Penglie Zhang
IPC分类号： C07D211/60
摘要： Intermediates and methods are provided for the preparation of selected C5aR antagonist compounds.
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公开(公告)号：US09783544B2
公开(公告)日：2017-10-10
申请号：US14836172
申请日：2015-08-26
申请人： ChemoCentryx, Inc.
发明人： Junfa Fan , Antoni Krasinski , Christopher W. Lange , Rebecca M. Lui , Jeffrey P. McMahon , Jay P. Powers , Yibin Zeng , Penglie Zhang
IPC分类号： A61K51/04 , C07D487/04 , G01N33/574
CPC分类号： C07D487/04 , A61K51/0459 , G01N33/57492 , G01N2333/7158
摘要： Compounds having formula I, or pharmaceutically acceptable salts, hydrates or N-oxides thereof are provided and are useful for binding to CXCR7, and treating diseases that are dependent, at least in part, on CXCR7 activity. Accordingly, the present invention provides in further aspects, compositions containing one or more of the above-noted compounds in admixture with a pharmaceutically acceptable excipient.
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公开(公告)号：US10988464B2
公开(公告)日：2021-04-27
申请号：US16414272
申请日：2019-05-16
申请人： CHEMOCENTRYX, INC.
发明人： Xi Chen , Dean R. Dragoli , Junfa Fan , Jaroslaw Kalisiak , Antoni Krasinski , Manmohan Reddy Leleti , Venkat Mali , Jeffrey McMahon , Rajinder Singh , Hiroko Tanaka , Ju Yang , Chao Yu , Penglie Zhang
IPC分类号： C07D405/14 , A61P35/00 , A61K31/341 , A61K31/4035 , A61K31/4155 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/506 , A61K45/06 , C07D209/46 , C07D307/52 , C07D405/12
摘要： Compounds are provided as chemokine inhibitors having the structure:
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公开(公告)号：US20200147066A1
公开(公告)日：2020-05-14
申请号：US16739204
申请日：2020-01-10
申请人： ChemoCentryx, Inc.
发明人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor T. Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew M.K. Pennell , John J. Wright , Antoni Krasinski , Qiang Wang
IPC分类号： A61K31/444 , C07C311/21 , C07D213/75 , C07D241/22 , C07D401/06 , C07D401/10 , C07D407/04 , C07D409/12 , C07D413/06 , C07D417/12 , C07D471/04 , C07D498/04 , A61K31/437 , A61K31/4439 , A61K45/06
摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.
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公开(公告)号：US10532044B2
公开(公告)日：2020-01-14
申请号：US16272401
申请日：2019-02-11
申请人： ChemoCentryx, Inc.
发明人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor T. Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew M. K. Pennell , John J. Wright , Antoni Krasinski , Qiang Wang
IPC分类号： A61K31/444 , C07C311/21 , C07D213/75 , C07D241/22 , C07D401/06 , C07D401/10 , C07D407/04 , C07D409/12 , C07D413/06 , C07D417/12 , C07D471/04 , C07D498/04 , A61K31/437 , A61K31/4439 , A61K45/06
摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.
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公开(公告)号：US10208050B2
公开(公告)日：2019-02-19
申请号：US15669410
申请日：2017-08-04
申请人： ChemoCentryx, Inc.
发明人： Antoni Krasinski , Sreenivas Punna , Solomon Ungashe , Qiang Wang , Yibin Zeng
IPC分类号： A61K31/519 , C07D487/04 , C07D471/04 , C07D471/12 , C07D473/00 , C07D213/79 , C07D213/81 , C07D213/84
摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases and as controls in assays for the identification of CCR2 antagonists.
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公开(公告)号：US10206912B2
公开(公告)日：2019-02-19
申请号：US15383788
申请日：2016-12-19
申请人： ChemoCentryx, Inc.
发明人： Solomon Ungashe , Zheng Wei , Arindrajit Basak , Trevor T. Charvat , Wei Chen , Jeff Jin , Jimmie Moore , Yibin Zeng , Sreenivas Punna , Daniel Dairaghi , Derek Hansen , Andrew M. K. Pennell , John J. Wright , Antoni Krasinski , Qiang Wang
IPC分类号： C07C311/21 , A61K31/444 , C07D213/75 , C07D241/22 , C07D401/06 , C07D401/10 , C07D407/04 , C07D409/12 , C07D413/06 , C07D417/12 , C07D471/04 , C07D498/04 , A61K31/437 , A61K31/4439 , A61K45/06
摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.
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10.发明授权公开(公告)号：US09745312B2
公开(公告)日：2017-08-29
申请号：US15195777
申请日：2016-06-28
申请人： ChemoCentryx, Inc.
发明人： Antoni Krasinski , Sreenivas Punna , Solomon Ungashe , Qiang Wang , Yibin Zeng
IPC分类号： C07D487/00 , C07D239/02 , C07D239/72 , C07D487/04 , C07D471/04 , C07D471/12 , C07D473/00 , C07D213/79 , C07D213/81 , C07D213/84
CPC分类号： C07D487/04 , C07D213/79 , C07D213/81 , C07D213/84 , C07D471/04 , C07D471/12 , C07D473/00
摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases and as controls in assays for the identification of CCR2 antagonists.
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