公开(公告)号：US20190167651A1

公开(公告)日：2019-06-06

申请号：US16272401

申请日：2019-02-11

申请人： ChemoCentryx, Inc.

发明人： Solomon Ungashe ,  Zheng Wei ,  Arindrajit Basak ,  Trevor T. Charvat ,  Wei Chen ,  Jeff Jin ,  Jimmie Moore ,  Yibin Zeng ,  Sreenivas Punna ,  Daniel Dairaghi ,  Derek Hansen ,  Andrew M.K. Pennell ,  John J. Wright ,  Antoni Krasinski ,  Qiang Wang

IPC分类号： A61K31/444 ,  A61K45/06 ,  A61K31/4439 ,  A61K31/437 ,  C07D498/04 ,  C07D471/04 ,  C07D417/12 ,  C07C311/21 ,  C07D409/12 ,  C07D407/04 ,  C07D401/10 ,  C07D401/06 ,  C07D241/22 ,  C07D213/75 ,  C07D413/06

CPC分类号： A61K31/444 ,  A61K31/437 ,  A61K31/4439 ,  A61K45/06 ,  C07C311/21 ,  C07D213/75 ,  C07D241/22 ,  C07D401/06 ,  C07D401/10 ,  C07D407/04 ,  C07D409/12 ,  C07D413/06 ,  C07D417/12 ,  C07D471/04 ,  C07D498/04

摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.

公开(公告)号：US11433061B2

公开(公告)日：2022-09-06

申请号：US16739204

申请日：2020-01-10

申请人： ChemoCentryx, Inc.

发明人： Solomon Ungashe ,  Zheng Wei ,  Arindrajit Basak ,  Trevor T. Charvat ,  Wei Chen ,  Jeff Jin ,  Jimmie Moore ,  Yibin Zeng ,  Sreenivas Punna ,  Daniel Dairaghi ,  Derek Hansen ,  Andrew M. K. Pennell ,  John J. Wright ,  Antoni Krasinski ,  Qiang Wang

IPC分类号： A61K31/444 ,  C07C311/21 ,  C07D213/75 ,  C07D241/22 ,  C07D401/06 ,  C07D401/10 ,  C07D407/04 ,  C07D409/12 ,  C07D413/06 ,  C07D417/12 ,  C07D471/04 ,  C07D498/04 ,  A61K31/437 ,  A61K31/4439 ,  A61K45/06

摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.

公开(公告)号：US20170095458A1

公开(公告)日：2017-04-06

申请号：US15383788

申请日：2016-12-19

申请人： ChemoCentryx, Inc.

发明人： Solomon Ungashe ,  Zheng Wei ,  Arindrajit Basak ,  Trevor T. Charvat ,  Wei Chen ,  Jeff Jin ,  Jimmie Moore ,  Yibin Zeng ,  Sreenivas Punna ,  Daniel Dairaghi ,  Derek Hansen ,  Andrew M.K. Pennell ,  John J. Wright

IPC分类号： A61K31/444 ,  A61K31/4439 ,  A61K31/437 ,  A61K45/06

CPC分类号： A61K31/444 ,  A61K31/437 ,  A61K31/4439 ,  A61K45/06 ,  C07C311/21 ,  C07D213/75 ,  C07D241/22 ,  C07D401/06 ,  C07D401/10 ,  C07D407/04 ,  C07D409/12 ,  C07D413/06 ,  C07D417/12 ,  C07D471/04 ,  C07D498/04

摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.

公开(公告)号：US20200147066A1

公开(公告)日：2020-05-14

申请号：US16739204

申请日：2020-01-10

申请人： ChemoCentryx, Inc.

发明人： Solomon Ungashe ,  Zheng Wei ,  Arindrajit Basak ,  Trevor T. Charvat ,  Wei Chen ,  Jeff Jin ,  Jimmie Moore ,  Yibin Zeng ,  Sreenivas Punna ,  Daniel Dairaghi ,  Derek Hansen ,  Andrew M.K. Pennell ,  John J. Wright ,  Antoni Krasinski ,  Qiang Wang

IPC分类号： A61K31/444 ,  C07C311/21 ,  C07D213/75 ,  C07D241/22 ,  C07D401/06 ,  C07D401/10 ,  C07D407/04 ,  C07D409/12 ,  C07D413/06 ,  C07D417/12 ,  C07D471/04 ,  C07D498/04 ,  A61K31/437 ,  A61K31/4439 ,  A61K45/06

摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.

公开(公告)号：US10532044B2

公开(公告)日：2020-01-14

申请号：US16272401

申请日：2019-02-11

申请人： ChemoCentryx, Inc.

发明人： Solomon Ungashe ,  Zheng Wei ,  Arindrajit Basak ,  Trevor T. Charvat ,  Wei Chen ,  Jeff Jin ,  Jimmie Moore ,  Yibin Zeng ,  Sreenivas Punna ,  Daniel Dairaghi ,  Derek Hansen ,  Andrew M. K. Pennell ,  John J. Wright ,  Antoni Krasinski ,  Qiang Wang

IPC分类号： A61K31/444 ,  C07C311/21 ,  C07D213/75 ,  C07D241/22 ,  C07D401/06 ,  C07D401/10 ,  C07D407/04 ,  C07D409/12 ,  C07D413/06 ,  C07D417/12 ,  C07D471/04 ,  C07D498/04 ,  A61K31/437 ,  A61K31/4439 ,  A61K45/06

摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.

公开(公告)号：US10206912B2

公开(公告)日：2019-02-19

申请号：US15383788

申请日：2016-12-19

申请人： ChemoCentryx, Inc.

发明人： Solomon Ungashe ,  Zheng Wei ,  Arindrajit Basak ,  Trevor T. Charvat ,  Wei Chen ,  Jeff Jin ,  Jimmie Moore ,  Yibin Zeng ,  Sreenivas Punna ,  Daniel Dairaghi ,  Derek Hansen ,  Andrew M. K. Pennell ,  John J. Wright ,  Antoni Krasinski ,  Qiang Wang

IPC分类号： C07C311/21 ,  A61K31/444 ,  C07D213/75 ,  C07D241/22 ,  C07D401/06 ,  C07D401/10 ,  C07D407/04 ,  C07D409/12 ,  C07D413/06 ,  C07D417/12 ,  C07D471/04 ,  C07D498/04 ,  A61K31/437 ,  A61K31/4439 ,  A61K45/06

摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.

公开(公告)号：US20140031348A1

公开(公告)日：2014-01-30

申请号：US13938119

申请日：2013-07-09

申请人： ChemoCentryx, Inc.

发明人： Solomon Ungashe ,  Zheng Wei ,  Arindrajit Basak ,  Trevor T. Charvat ,  Wei Chen ,  Jeff Jin ,  Jimmie Moore ,  Yibin Zeng ,  Sreenivas Punna ,  Daniel Dairaghi ,  Derek Hansen ,  Andrew M.K. Pennell ,  John J. Wright

IPC分类号： A61K31/5383 ,  A61K31/5377 ,  A61K31/502 ,  A61K45/06 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/44 ,  A61K31/444 ,  A61K31/538 ,  A61K31/4965

CPC分类号： A61K31/5383 ,  A61K31/44 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4965 ,  A61K31/502 ,  A61K31/5377 ,  A61K31/538 ,  A61K45/06 ,  C07C311/21 ,  C07D213/75 ,  C07D241/22 ,  C07D401/06 ,  C07D401/10 ,  C07D407/04 ,  C07D409/12 ,  C07D413/06 ,  C07D417/12 ,  C07D471/04 ,  C07D498/04

摘要： Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.

摘要翻译： 提供了作为CCR2受体的有效拮抗剂的化合物。 动物实验表明，这些化合物可用于治疗炎症，CCR2的标志性疾病。 化合物通常为芳基磺酰胺衍生物，并且可用于药物组合物，用于治疗CCR2介导的疾病的方法，以及用于鉴定CCR2拮抗剂的测定中的对照。