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公开(公告)号：US11945805B2
公开(公告)日：2024-04-02
申请号：US17243872
申请日：2021-04-29
申请人： CHEMOCENTRYX, INC.
发明人： Xi Chen , Dean R. Dragoli , Junfa Fan , Jaroslaw Kalisiak , Manmohan Reddy Leleti , Viengkham Malathong , Jeffrey McMahon , Hiroko Tanaka , Ju Yang , Chao Yu , Penglie Zhang , Venkat Mali
IPC分类号： C07D405/12 , A61K31/4035 , A61K31/422 , A61K31/4439 , A61K45/06 , A61P11/00 , A61P17/06 , A61P35/00 , A61P37/00 , C07B59/00 , C07D405/14 , C07D413/12
CPC分类号： C07D405/12 , A61K31/4035 , A61K31/422 , A61K31/4439 , A61K45/06 , A61P11/00 , A61P17/06 , A61P35/00 , A61P37/00 , C07B59/002 , C07D405/14 , C07D413/12 , C07B2200/05 , A61K31/4035 , A61K2300/00 , A61K31/422 , A61K2300/00 , A61K31/4439 , A61K2300/00
摘要： Compounds are provided as inhibitors of CXCR2, having the structure:
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公开(公告)号：US11773091B2
公开(公告)日：2023-10-03
申请号：US17735283
申请日：2022-05-03
申请人： CHEMOCENTRYX, INC.
发明人： Pingchen Fan , Christopher W. Lange , Rebecca M. Lui , Viengkham Malathong , Venkat Reddy Mali , Sreenivas Punna , Rajinder Singh , Hiroko Tanaka , Yibin Zeng , Penglie Zhang
IPC分类号： C07D471/04 , A61P37/02 , C07D519/00
CPC分类号： C07D471/04 , A61P37/02 , C07D519/00
摘要： The present disclosure provides, inter alia, Compounds of Formula (I)
or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.-
公开(公告)号：US10988464B2
公开(公告)日：2021-04-27
申请号：US16414272
申请日：2019-05-16
申请人： CHEMOCENTRYX, INC.
发明人： Xi Chen , Dean R. Dragoli , Junfa Fan , Jaroslaw Kalisiak , Antoni Krasinski , Manmohan Reddy Leleti , Venkat Mali , Jeffrey McMahon , Rajinder Singh , Hiroko Tanaka , Ju Yang , Chao Yu , Penglie Zhang
IPC分类号： C07D405/14 , A61P35/00 , A61K31/341 , A61K31/4035 , A61K31/4155 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/506 , A61K45/06 , C07D209/46 , C07D307/52 , C07D405/12
摘要： Compounds are provided as chemokine inhibitors having the structure:
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公开(公告)号：US10786494B2
公开(公告)日：2020-09-29
申请号：US16150796
申请日：2018-10-03
申请人： CHEMOCENTRYX, INC.
发明人： Daniel Dairaghi , Dean R. Dragoli , Jaroslaw Kalisiak , Christopher W. Lange , Manmohan Reddy Leleti , Yandong Li , Rebecca M. Lui , Venkat Reddy Mali , Viengkham Malathong , Jay P. Powers , Hiroko Tanaka , Joanne Tan , Matthew J. Walters , Ju Yang , Penglie Zhang
IPC分类号： A61K31/47 , C07D215/48 , C07D405/04 , C07D405/14 , A61K31/4709
摘要： Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6:
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公开(公告)号：US10744118B2
公开(公告)日：2020-08-18
申请号：US15074976
申请日：2016-03-18
申请人： ChemoCentryx, Inc.
发明人： Xi Chen , Pingchen Fan , Yandong Li , Jay P. Powers , Viengkham Malathong , Sreenivas Punna , Hiroko Tanaka , Penglie Zhang , Dean Dragoli
IPC分类号： A61K31/4178 , A61K31/4155 , A61K45/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D471/04 , C07D487/04 , A61K31/4192 , A61K31/4196
摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.
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公开(公告)号：US10370363B2
公开(公告)日：2019-08-06
申请号：US15722785
申请日：2017-10-02
申请人： CHEMOCENTRYX, INC.
发明人： Xi Chen , Dean R. Dragoli , Junfa Fan , Jaroslaw Kalisiak , Manmohan Reddy Leleti , Viengkham Malathong , Jeffrey McMahon , Hiroko Tanaka , Ju Yang , Chao Yu , Penglie Zhang , Venkat Mali
IPC分类号： A61K45/06 , C07B59/00 , A61K31/422 , C07D405/12 , C07D405/14 , C07D413/12 , A61K31/4035 , A61K31/4439
摘要： Compounds are provided as inhibitors of CXCR2, having the structure:
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公开(公告)号：US09750722B2
公开(公告)日：2017-09-05
申请号：US14878784
申请日：2015-10-08
申请人： ChemoCentryx, Inc.
发明人： Xi Chen , Dean R. Dragoli , Pingchen Fan , Juan C. Jaen , Yandong Li , Jay P. Powers , Viengkham Malathong , Sreenivas Punna , Hiroko Tanaka , Penglie Zhang
IPC分类号： C07D233/88 , A61K31/437 , A61K31/4178 , A61K45/06 , C07D401/12 , A61K31/4155 , C07D231/40 , A61K31/4192 , A61K31/4196 , C07D471/04 , C07D403/12
CPC分类号： A61K31/4155 , A61K31/4178 , A61K31/4192 , A61K31/4196 , A61K31/437 , A61K45/06 , C07D231/40 , C07D233/88 , C07D401/12 , C07D403/12 , C07D471/04
摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.
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公开(公告)号：US20160340356A1
公开(公告)日：2016-11-24
申请号：US15158713
申请日：2016-05-19
申请人： CHEMOCENTRYX, INC.
发明人： Junfa Fan , Jaroslaw Kalisiak , Rebecca M. Lui , Venkat Reddy Mali , Jeffrey P. McMahon , Jay P. Powers , Hiroko Tanaka , Yibin Zeng , Penglie Zhang
IPC分类号： C07D471/04 , C07D405/04 , A61K31/453 , A61K31/4725 , C07D413/14 , A61K31/536 , C07D405/14 , A61K31/4545 , A61K31/496
CPC分类号： C07D471/04 , A61K31/453 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/536 , C07D405/04 , C07D405/14 , C07D413/14
摘要： Compounds are provided that are modulators of the CCR2 receptor. The compounds have the general formula (I): and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of CCR2 receptors.
摘要翻译： 并且可用于药物组合物，用于治疗涉及CCR2受体的病理性激活的疾病和病症的方法。
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公开(公告)号：US09340509B2
公开(公告)日：2016-05-17
申请号：US14557949
申请日：2014-12-02
申请人： ChemoCentryx, Inc.
发明人： Daniel Dairaghi , Dean R. Dragoli , Jarek Kalisiak , Christopher W. Lange , Manmohan Reddy Leleti , Yandong Li , Rebecca M. Lui , Venkat Reddy Mali , Viengkham Malathong , Jay P. Powers , Hiroko Tanaka , Joanne Tan , Matthew J. Walters , Ju Yang , Penglie Zhang
IPC分类号： C07D215/48 , C07D405/14 , C07D405/04
CPC分类号： A61K31/47 , A61K31/4709 , C07D215/48 , C07D405/04 , C07D405/14
摘要： Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6:
摘要翻译： 提供式（I）化合物，其可用于治疗至少部分由CCR6调节的疾病或病症：
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公开(公告)号：US11040960B2
公开(公告)日：2021-06-22
申请号：US16438880
申请日：2019-06-12
申请人： CHEMOCENTRYX, INC.
发明人： Xi Chen , Dean R. Dragoli , Junfa Fan , Jaroslaw Kalisiak , Manmohan Reddy Leleti , Viengkham Malathong , Jeffrey McMahon , Hiroko Tanaka , Ju Yang , Chao Yu , Penglie Zhang , Venkat Mali
IPC分类号： C07D405/12 , A61P11/00 , A61P37/00 , A61P17/06 , A61P35/00 , A61K31/4035 , A61K31/4439 , A61K45/06 , C07B59/00 , C07D405/14 , C07D413/12 , A61K31/422
摘要： Compounds are provided as inhibitors of CXCR2, having the structure:
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