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公开(公告)号：US20160296517A1
公开(公告)日：2016-10-13
申请号：US15050691
申请日：2016-02-23
申请人： CHEMOCENTRYX, INC.
发明人： Penglie ZHANG , Andrew M. K. Pennell , John J. Kim Wright , Wei Chen , Manmohan R. Leleti , Yandong Li , Lianfa Li , Yuan Xu , Mark M. Gleason , Yibin Zeng , Kevin Lloyd Greenman
IPC分类号： A61K31/496 , A61K31/5377 , A61K45/06
CPC分类号： A61K31/496 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D487/04
摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
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公开(公告)号：US08906938B2
公开(公告)日：2014-12-09
申请号：US13894209
申请日：2013-05-14
申请人： ChemoCentryx, Inc.
发明人： Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay P. Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
IPC分类号： A61K31/445 , C07D211/60 , A61K31/454 , C07D413/14 , C07D401/10 , A61K31/5377 , C07D405/10 , C07D401/06 , C07D401/14 , A61K31/451 , C07D413/12 , A61K31/4545
CPC分类号： A61K31/5377 , A61K31/445 , A61K31/451 , A61K31/454 , A61K31/4545 , C07D211/60 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D413/12 , C07D413/14
摘要： Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.
摘要翻译： 提供了作为C5a受体调节剂的化合物。 化合物是取代的哌啶并且可用于药物组合物，用于治疗涉及C5a受体的病理活化的疾病和病症的方法。
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公开(公告)号：US20210269398A1
公开(公告)日：2021-09-02
申请号：US17075131
申请日：2020-10-20
申请人： CHEMOCENTRYX, INC.
发明人： Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
IPC分类号： C07D211/60 , C07D401/14 , C07D413/14 , A61K31/445 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/5377 , C07D401/06 , C07D401/10 , C07D401/12 , C07D405/10 , C07D413/12 , C07D405/12
摘要： Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.
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公开(公告)号：US10660897B2
公开(公告)日：2020-05-26
申请号：US16030729
申请日：2018-07-09
申请人： CHEMOCENTRYX, INC.
发明人： Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
IPC分类号： A61K31/5377 , A61K31/445 , A61K31/451 , A61K31/454 , A61K31/4545 , C07D401/06 , C07D401/10 , C07D401/14 , C07D405/10 , C07D413/12 , C07D211/60 , C07D413/14 , C07D401/12
摘要： Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.
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公开(公告)号：US10035768B2
公开(公告)日：2018-07-31
申请号：US15722819
申请日：2017-10-02
申请人： CHEMOCENTRYX, INC.
发明人： Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
IPC分类号： C07D211/60 , C07D413/12 , C07D405/10 , C07D401/12 , C07D401/10 , C07D401/06 , A61K31/5377 , A61K31/4545 , A61K31/454 , A61K31/451 , A61K31/445 , C07D413/14 , C07D401/14 , C07D405/12
CPC分类号： C07D211/60 , A61K31/445 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/5377 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D405/12 , C07D413/12 , C07D413/14
摘要： Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.
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公开(公告)号：US20150141425A1
公开(公告)日：2015-05-21
申请号：US14531385
申请日：2014-11-03
申请人： ChemoCentryx, Inc.
发明人： Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
IPC分类号： C07D211/60 , C07D401/12 , C07D401/10 , C07D401/06
CPC分类号： A61K31/5377 , A61K31/445 , A61K31/451 , A61K31/454 , A61K31/4545 , C07D211/60 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D413/12 , C07D413/14
摘要： Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.
摘要翻译： 提供了作为C5a受体调节剂的化合物。 化合物是取代的哌啶并且可用于药物组合物，用于治疗涉及C5a受体的病理活化的疾病和病症的方法。
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公开(公告)号：US20130317028A1
公开(公告)日：2013-11-28
申请号：US13894209
申请日：2013-05-14
申请人： ChemoCentryx, Inc.
发明人： Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay Powers , Horoko Tanaka , Ju Yang , Yibin Zeng
IPC分类号： C07D211/60 , C07D413/14 , C07D401/06
CPC分类号： A61K31/5377 , A61K31/445 , A61K31/451 , A61K31/454 , A61K31/4545 , C07D211/60 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D413/12 , C07D413/14
摘要： Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.
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公开(公告)号：US20170065604A1
公开(公告)日：2017-03-09
申请号：US15354878
申请日：2016-11-17
申请人： CHEMOCENTRYX, INC.
发明人： Pingchen FAN , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong LI , Jay POWERS , Hiroko Tanaka , Ju YANG , Yibin ZENG
IPC分类号： A61K31/5377 , A61K31/454 , A61K31/445 , A61K31/451 , A61K31/4545
CPC分类号： A61K31/5377 , A61K31/445 , A61K31/451 , A61K31/454 , A61K31/4545 , C07D211/60 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D413/12 , C07D413/14
摘要： Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of C5a receptors.
摘要翻译： 提供了作为C5a受体调节剂的化合物。 化合物是取代的哌啶并且可用于药物组合物，用于治疗涉及C5a受体的病理活化的疾病和病症的方法。
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公开(公告)号：US09573897B2
公开(公告)日：2017-02-21
申请号：US14846487
申请日：2015-09-04
申请人： ChemoCentryx, Inc.
发明人： Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
IPC分类号： C07D211/60 , C07D401/14 , C07D413/14 , A61K31/445 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/5377 , C07D401/06 , C07D401/10 , C07D401/12 , C07D405/10 , C07D413/12 , C07D405/12
CPC分类号： C07D211/60 , A61K31/445 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/5377 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D405/12 , C07D413/12 , C07D413/14
摘要： Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.
摘要翻译： 提供了作为C5a受体调节剂的化合物。 化合物是取代的哌啶并且可用于药物组合物，用于治疗涉及C5a受体的病理活化的疾病和病症的方法。
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公开(公告)号：US09296740B2
公开(公告)日：2016-03-29
申请号：US13774938
申请日：2013-02-22
申请人： ChemoCentryx, Inc.
发明人： Penglie Zhang , Andrew M. K. Pennell , John J. Kim Wright , Wei Chen , Manmohan R. Leleti , Yandong Li , Lianfa Li , Yuan Xu , Mark M. Gleason , Yibin Zeng , Kevin Lloyd Greenman
IPC分类号： C07D471/04 , C07D487/04
CPC分类号： A61K31/496 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D487/04
摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
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