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公开(公告)号：US20210269398A1
公开(公告)日：2021-09-02
申请号：US17075131
申请日：2020-10-20
申请人： CHEMOCENTRYX, INC.
发明人： Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
IPC分类号： C07D211/60 , C07D401/14 , C07D413/14 , A61K31/445 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/5377 , C07D401/06 , C07D401/10 , C07D401/12 , C07D405/10 , C07D413/12 , C07D405/12
摘要： Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.
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公开(公告)号：US10342781B2
公开(公告)日：2019-07-09
申请号：US15659488
申请日：2017-07-25
申请人： CHEMOCENTRYX, INC.
发明人： Xi Chen , Dean R. Dragoli , Pingchen Fan , Juan C. Jaen , Yandong Li , Jay P. Powers , Viengkham Malathong , Sreenivas Punna , Hiroko Tanaka , Penglie Zhang
IPC分类号： A61K45/06 , A61K31/437 , C07D231/40 , C07D233/88 , C07D401/12 , C07D403/12 , C07D471/04 , A61K31/4155 , A61K31/4178 , A61K31/4192 , A61K31/4196
摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.
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公开(公告)号：US20160296508A1
公开(公告)日：2016-10-13
申请号：US15074965
申请日：2016-03-18
申请人： ChemoCentryx, Inc.
发明人： Daniel Dairaghi , Dean R. Dragoli , Jarek Kalisiak , Christopher W. Lange , Manmohan Reddy Leleti , Yandong Li , Rebecca M. Lui , Venkat Reddy Mali , Viengkham Malathong , Jay P. Powers , Hiroko Tanaka , Joanne Tan , Matthew J. Walters , Ju Yang , Penglie Zhang
IPC分类号： A61K31/47 , A61K31/4709
CPC分类号： A61K31/47 , A61K31/4709 , C07D215/48 , C07D405/04 , C07D405/14
摘要： Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6:
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公开(公告)号：US11142521B2
公开(公告)日：2021-10-12
申请号：US16526338
申请日：2019-07-30
申请人： CHEMOCENTRYX, INC.
发明人： Trevor T. Charvat , Junfa Fan , Christopher W. Lange , Manmohan Reddy Leleti , Yandong Li , Venkat Reddy Mali , Jeffrey P. McMahon , Jay Powers , Sreenivas Punna , Ju Yang
IPC分类号： C07D413/06 , C07D401/04 , C07D403/06 , C07D405/06 , C07D417/04 , C07D211/56 , C07D295/135 , C07D211/62 , C07D401/06 , C07D211/26 , C07D211/70 , C07D241/04 , C07D207/16 , C07D211/34 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/495 , A61K31/496 , A61K31/5377
摘要： Aniline compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.
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公开(公告)号：US10786494B2
公开(公告)日：2020-09-29
申请号：US16150796
申请日：2018-10-03
申请人： CHEMOCENTRYX, INC.
发明人： Daniel Dairaghi , Dean R. Dragoli , Jaroslaw Kalisiak , Christopher W. Lange , Manmohan Reddy Leleti , Yandong Li , Rebecca M. Lui , Venkat Reddy Mali , Viengkham Malathong , Jay P. Powers , Hiroko Tanaka , Joanne Tan , Matthew J. Walters , Ju Yang , Penglie Zhang
IPC分类号： A61K31/47 , C07D215/48 , C07D405/04 , C07D405/14 , A61K31/4709
摘要： Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6:
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公开(公告)号：US10744118B2
公开(公告)日：2020-08-18
申请号：US15074976
申请日：2016-03-18
申请人： ChemoCentryx, Inc.
发明人： Xi Chen , Pingchen Fan , Yandong Li , Jay P. Powers , Viengkham Malathong , Sreenivas Punna , Hiroko Tanaka , Penglie Zhang , Dean Dragoli
IPC分类号： A61K31/4178 , A61K31/4155 , A61K45/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D471/04 , C07D487/04 , A61K31/4192 , A61K31/4196
摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.
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公开(公告)号：US09790204B2
公开(公告)日：2017-10-17
申请号：US14834836
申请日：2015-08-25
申请人： ChemoCentryx, Inc.
发明人： Manmohan Reddy Leleti , Yandong Li , Venkat Reddy Mali , Jay Powers , Ju Yang
IPC分类号： C07D401/14 , C07D235/06 , C07D401/04 , C07D403/12 , C07D403/14 , C07D403/04 , C07D405/14
CPC分类号： C07D401/14 , C07D235/06 , C07D401/04 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14
摘要： Benzimidazole, benzopyrazole and benzotriazole compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.
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公开(公告)号：US09750722B2
公开(公告)日：2017-09-05
申请号：US14878784
申请日：2015-10-08
申请人： ChemoCentryx, Inc.
发明人： Xi Chen , Dean R. Dragoli , Pingchen Fan , Juan C. Jaen , Yandong Li , Jay P. Powers , Viengkham Malathong , Sreenivas Punna , Hiroko Tanaka , Penglie Zhang
IPC分类号： C07D233/88 , A61K31/437 , A61K31/4178 , A61K45/06 , C07D401/12 , A61K31/4155 , C07D231/40 , A61K31/4192 , A61K31/4196 , C07D471/04 , C07D403/12
CPC分类号： A61K31/4155 , A61K31/4178 , A61K31/4192 , A61K31/4196 , A61K31/437 , A61K45/06 , C07D231/40 , C07D233/88 , C07D401/12 , C07D403/12 , C07D471/04
摘要： Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.
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公开(公告)号：US09567323B2
公开(公告)日：2017-02-14
申请号：US14452341
申请日：2014-08-05
申请人： ChemoCentryx, Inc.
发明人： Trevor T. Charvat , Junfa Fan , Christopher W. Lange , Manmohan Reddy Leleti , Yandong Li , Venkat Reddy Mali , Jeffrey P. McMahon , Jay Powers , Sreenivas Punna , Ju Yang
IPC分类号： A01N43/00 , A61K31/55 , C07D413/06 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/06 , C07D417/04 , C07D211/56 , C07D295/135 , C07D211/62 , C07D211/26 , C07D211/70 , C07D241/04 , C07D207/16 , C07D211/34
CPC分类号： C07D413/06 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/495 , A61K31/496 , A61K31/5377 , C07D207/16 , C07D211/26 , C07D211/34 , C07D211/56 , C07D211/62 , C07D211/70 , C07D241/04 , C07D295/135 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/06 , C07D417/04
摘要： Aniline compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.
摘要翻译： 提供了与CCR（4）结合的苯胺化合物，可用于治疗过敏性疾病，自身免疫性疾病，移植物排斥反应和癌症等疾病。
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公开(公告)号：US09340509B2
公开(公告)日：2016-05-17
申请号：US14557949
申请日：2014-12-02
申请人： ChemoCentryx, Inc.
发明人： Daniel Dairaghi , Dean R. Dragoli , Jarek Kalisiak , Christopher W. Lange , Manmohan Reddy Leleti , Yandong Li , Rebecca M. Lui , Venkat Reddy Mali , Viengkham Malathong , Jay P. Powers , Hiroko Tanaka , Joanne Tan , Matthew J. Walters , Ju Yang , Penglie Zhang
IPC分类号： C07D215/48 , C07D405/14 , C07D405/04
CPC分类号： A61K31/47 , A61K31/4709 , C07D215/48 , C07D405/04 , C07D405/14
摘要： Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6:
摘要翻译： 提供式（I）化合物，其可用于治疗至少部分由CCR6调节的疾病或病症：
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