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公开(公告)号:US08084222B2
公开(公告)日:2011-12-27
申请号:US12507051
申请日:2009-07-21
申请人: Cheng Liu , Jingyi Xiang , Su Yan , Pei Wang , Wei Chan Tai
发明人: Cheng Liu , Jingyi Xiang , Su Yan , Pei Wang , Wei Chan Tai
CPC分类号: C07K16/18 , C07K2317/73 , C07K2317/732 , C12N9/1048 , C12P21/005
摘要: The present disclosure provides compositions and methods comprising cells producing glycoproteins with variant glycosylation patterns. The methods and compositions may be used in producing antibodies and proteins of therapeutic value.
摘要翻译: 本公开提供包含产生具有变体糖基化模式的糖蛋白的细胞的组合物和方法。 所述方法和组合物可用于产生具有治疗价值的抗体和蛋白质。
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公开(公告)号:US08080415B2
公开(公告)日:2011-12-20
申请号:US12507046
申请日:2009-07-21
申请人: Cheng Liu , Jingyi Xiang , Su Yan , Pei Wang , Wei Chan Tai
发明人: Cheng Liu , Jingyi Xiang , Su Yan , Pei Wang , Wei Chan Tai
IPC分类号: C12M1/00
CPC分类号: C07K16/18 , C07K2317/73 , C07K2317/732 , C12N9/1048 , C12P21/005
摘要: The present disclosure provides compositions and methods comprising cells producing glycoproteins with variant glycosylation patterns. The methods and compositions may be used in producing antibodies and proteins of therapeutic value.
摘要翻译: 本公开提供包含产生具有变体糖基化模式的糖蛋白的细胞的组合物和方法。 所述方法和组合物可用于产生具有治疗价值的抗体和蛋白质。
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公开(公告)号:US20120107874A1
公开(公告)日:2012-05-03
申请号:US13306777
申请日:2011-11-29
申请人: Cheng Liu , Jingyi Xiang , Su Yan , Pei Wang , Wei Chan Tai
发明人: Cheng Liu , Jingyi Xiang , Su Yan , Pei Wang , Wei Chan Tai
IPC分类号: C12P21/00 , C07K14/00 , C07K16/30 , C07K16/00 , C07K16/18 , C07K16/40 , C08B37/00 , C12N9/96
CPC分类号: C07K16/18 , C07K2317/73 , C07K2317/732 , C12N9/1048 , C12P21/005
摘要: The present disclosure provides compositions and methods comprising cells producing glycoproteins with variant glycosylation patterns. The methods and compositions may be used in producing antibodies and proteins of therapeutic value.
摘要翻译: 本公开提供包含产生具有变体糖基化模式的糖蛋白的细胞的组合物和方法。 所述方法和组合物可用于产生具有治疗价值的抗体和蛋白质。
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公开(公告)号:US20100081794A1
公开(公告)日:2010-04-01
申请号:US12507044
申请日:2009-07-21
申请人: Cheng Liu , Jingyi Xiang , Su Yan , Pei Wang , Wei Chan Tai
发明人: Cheng Liu , Jingyi Xiang , Su Yan , Pei Wang , Wei Chan Tai
CPC分类号: C07K16/18 , C07K2317/73 , C07K2317/732 , C12N9/1048 , C12P21/005
摘要: The present disclosure provides compositions and methods comprising cells producing glycoproteins with variant glycosylation patterns. The methods and compositions may be used in producing antibodies and proteins of therapeutic value.
摘要翻译: 本公开提供包含产生具有变体糖基化模式的糖蛋白的细胞的组合物和方法。 所述方法和组合物可用于产生具有治疗价值的抗体和蛋白质。
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公开(公告)号:US08025879B2
公开(公告)日:2011-09-27
申请号:US12507044
申请日:2009-07-21
申请人: Cheng Liu , Jingyi Xiang , Su Yan , Pei Wang , Wei Chan Tai
发明人: Cheng Liu , Jingyi Xiang , Su Yan , Pei Wang , Wei Chan Tai
CPC分类号: C07K16/18 , C07K2317/73 , C07K2317/732 , C12N9/1048 , C12P21/005
摘要: The present disclosure provides compositions and methods comprising cells producing glycoproteins with variant glycosylation patterns. The methods and compositions may be used in producing antibodies and proteins of therapeutic value.
摘要翻译: 本公开提供包含产生具有变体糖基化模式的糖蛋白的细胞的组合物和方法。 所述方法和组合物可用于产生具有治疗价值的抗体和蛋白质。
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公开(公告)号:US20100081195A1
公开(公告)日:2010-04-01
申请号:US12507046
申请日:2009-07-21
申请人: Cheng Liu , Jingyi Xiang , Su Yan , Pei Wang , Wei Chan Tai
发明人: Cheng Liu , Jingyi Xiang , Su Yan , Pei Wang , Wei Chan Tai
CPC分类号: C07K16/18 , C07K2317/73 , C07K2317/732 , C12N9/1048 , C12P21/005
摘要: The present disclosure provides compositions and methods comprising cells producing glycoproteins with variant glycosylation patterns. The methods and compositions may be used in producing antibodies and proteins of therapeutic value.
摘要翻译: 本公开提供包含产生具有变体糖基化模式的糖蛋白的细胞的组合物和方法。 所述方法和组合物可用于产生具有治疗价值的抗体和蛋白质。
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公开(公告)号:US20100081150A1
公开(公告)日:2010-04-01
申请号:US12507051
申请日:2009-07-21
申请人: Cheng Liu , Jingyi Xiang , Su Yan , Pei Wang , Wei Chan Tai
发明人: Cheng Liu , Jingyi Xiang , Su Yan , Pei Wang , Wei Chan Tai
CPC分类号: C07K16/18 , C07K2317/73 , C07K2317/732 , C12N9/1048 , C12P21/005
摘要: The present disclosure provides compositions and methods comprising cells producing glycoproteins with variant glycosylation patterns. The methods and compositions may be used in producing antibodies and proteins of therapeutic value.
摘要翻译: 本公开提供包含产生具有变体糖基化模式的糖蛋白的细胞的组合物和方法。 所述方法和组合物可用于产生具有治疗价值的抗体和蛋白质。
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公开(公告)号:US20100081172A1
公开(公告)日:2010-04-01
申请号:US12507047
申请日:2009-07-21
申请人: Cheng Liu , Jingyi Xiang , Su Yan , Pei Wang , Wei Chan Tai
发明人: Cheng Liu , Jingyi Xiang , Su Yan , Pei Wang , Wei Chan Tai
CPC分类号: C07K16/18 , C07K2317/73 , C07K2317/732 , C12N9/1048 , C12P21/005
摘要: The present disclosure provides compositions and methods comprising cells producing glycoproteins with variant glycosylation patterns. The methods and compositions may be used in producing antibodies and proteins of therapeutic value.
摘要翻译: 本公开提供包含产生具有变体糖基化模式的糖蛋白的细胞的组合物和方法。 所述方法和组合物可用于产生具有治疗价值的抗体和蛋白质。
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公开(公告)号:US20120268408A1
公开(公告)日:2012-10-25
申请号:US13541450
申请日:2012-07-03
申请人: Zhigang Chen , Pei Wang
发明人: Zhigang Chen , Pei Wang
IPC分类号: G06F3/041
CPC分类号: H04M1/72544 , G06F3/0414 , G06F3/0488 , G06F2203/04806
摘要: A method for displaying a picture/interface on a screen of a terminal comprises obtaining relevant information on a pressure, when the pressure is detected to be applied on the screen, obtaining a corresponding display mode according to the relevant information on the pressure, and displaying the picture/interface according to the display mode. The terminal may adjust the display mode automatically according to the pressure applied on the screen of the terminal by the user, with strong real-time property, simplifying the operations by the user on the terminal and improving the user's experience.
摘要翻译: 一种用于在终端屏幕上显示图像/界面的方法包括获取有关压力的相关信息,当检测到压力被施加在屏幕上时,根据关于压力的相关信息获得相应的显示模式,并且显示 图片/界面根据显示模式。 终端可以根据用户屏幕上施加的压力自动调整显示模式,实时性强,简化了用户对终端的操作,提高了用户体验。
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公开(公告)号:US06995251B1
公开(公告)日:2006-02-07
申请号:US09830810
申请日:1999-10-28
申请人: Martin M. Matzuk , Pei Wang
发明人: Martin M. Matzuk , Pei Wang
IPC分类号: C07H21/00
摘要: Ovary-specific proteins O1-180, O1-184 and O1-236, polynucleotides encoding them, antibodies which are immunoreactive with them and vectors and host cells containing O1-180, O1-184 or O1-236 are provided. Also provided are methods for detecting cell proliferative or degenerative disorders of ovarian origin and which are associated with O1-180, O1-184 or O1-236. Further provided are methods for the evaluation of potential contraceptives using the proteins of the invention, as well as methods for the screening for genetic mutations in signaling pathways that are associated with some forms of human infertility or gynecological cancers, also using the proteins/mRNAs/genes of the invention. The proteins/mRNAs/genes of the invention may also be used as markers for identifying primary and metastatic neoplasms of ovarian origin and as indicators of developmental anomalies in prenatal screening procedures. Furthermore, assays of the proteins/mRNAs/genes of the invention can be used in diagnostic assays for detecting forms of infertility and other diseases, including germ cell tumors and polycystic ovary syndrome. The proteins of the invention may be useful targets for in vitro fertilization procedures or in enhancing the number of eggs that can be retrieved from the human donor, e.g., in enhancing the success rate.
摘要翻译: 提供卵巢特异性蛋白质O1-180,O1-184和O1-236,编码它们的多核苷酸,与它们免疫反应的抗体和载体以及含有O1-180,O1-184或O1-236的宿主细胞。 还提供了用于检测卵巢起源的细胞增殖或退行性疾病的方法,其与O1-180,O1-184或O1-236相关。 还提供了使用本发明的蛋白质评价潜在的避孕药物的方法,以及用于筛选与某些形式的人类不育症或妇科癌症相关的信号通路中的遗传突变的方法,也使用蛋白质/ mRNAs / 本发明的基因。 本发明的蛋白质/ mRNAs /基因也可用作识别卵巢原发性和转移性肿瘤的标志物,以及作为产前筛查程序发育异常的指标。 此外,本发明的蛋白质/ mRNA /基因的测定可用于检测不育症和其他疾病形式的诊断测定,包括生殖细胞肿瘤和多囊卵巢综合征。 本发明的蛋白质可以是体外受精程序的有用靶标,或增强可从人类供体获取的卵数,例如提高成功率。
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