公开(公告)号：US10100036B2

公开(公告)日：2018-10-16

申请号：US15713934

申请日：2017-09-25

申请人： Chengyuan Liang ,  Minyi Jia ,  Xingke Ju ,  Lei Tian ,  Danni Tian ,  Shunjun Ding

发明人： Chengyuan Liang ,  Minyi Jia ,  Xingke Ju ,  Lei Tian ,  Danni Tian ,  Shunjun Ding

IPC分类号： C07D401/12

摘要： A lappaconitine aza-cinnamic acid derivative having the following formula (I): X is C or N, and R1, R2, and R3 are independently H or lower alkyl. A method of preparing the lappaconitine aza-cinnamic acid derivative of formula (I) is also disclosed.

公开(公告)号：US10494377B1

公开(公告)日：2019-12-03

申请号：US16120403

申请日：2018-09-03

申请人： Bin Tian ,  Xingke Ju ,  Lei Tian ,  Jie Li ,  Songsong Ruan ,  Minyi Jia ,  Danni Tian ,  Han Li ,  Qianqian Zhao ,  Xuechuan Wang ,  Chengyuan Liang

发明人： Bin Tian ,  Xingke Ju ,  Lei Tian ,  Jie Li ,  Songsong Ruan ,  Minyi Jia ,  Danni Tian ,  Han Li ,  Qianqian Zhao ,  Xuechuan Wang ,  Chengyuan Liang

IPC分类号： C07D493/04

摘要： A compound having the formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.

公开(公告)号：US10023765B2

公开(公告)日：2018-07-17

申请号：US15605985

申请日：2017-05-26

申请人： Chengyuan Liang ,  Minyi Jia ,  Danni Tian ,  Shunjun Ding ,  Xuechuan Wang ,  Han Li ,  Wei Liu

发明人： Chengyuan Liang ,  Minyi Jia ,  Danni Tian ,  Shunjun Ding ,  Xuechuan Wang ,  Han Li ,  Wei Liu

IPC分类号： C09H3/02 ,  B05D3/00 ,  B05D1/18 ,  B65D65/46

摘要： A method of preparing a sturgeon skin gelatin with antioxidant activity includes: 1) soaking sturgeon skin in water, and sonicating the sturgeon skin; 2) cutting the sturgeon skin, soaking the sturgeon skin in a NaOH solution, and soaking the sturgeon skin in an HCl solution; 3) washing the sturgeon skin of step 2) to neutral, placing the sturgeon skin in an extraction solution for extracting sturgeon skin protein; and 4) obtaining the sturgeon skin gelatin. A method of preparing a sturgeon skin gelatin film includes: 1) dissolving sturgeon skin gelatin in water to obtain a sturgeon skin gelatin solution; 2) adding glycerine to the sturgeon skin gelatin solution; and 3) obtaining the sturgeon skin gelatin film.

公开(公告)号：US09758486B1

公开(公告)日：2017-09-12

申请号：US15489713

申请日：2017-04-17

申请人： Chengyuan Liang ,  Danni Tian ,  Minyi Jia ,  Xiaolin Xie ,  Dezhu Zhang ,  Weihui Ju ,  Shunjun Ding ,  Xuechuan Wang

发明人： Chengyuan Liang ,  Danni Tian ,  Minyi Jia ,  Xiaolin Xie ,  Dezhu Zhang ,  Weihui Ju ,  Shunjun Ding ,  Xuechuan Wang

IPC分类号： C07D231/36 ,  C07D231/22 ,  C07D231/26

CPC分类号： C07D231/36 ,  C07D231/22 ,  C07D231/26

摘要： A compound with antitumor activities represented by formula I: In formula I, R1 is alkyl, alkoxy, or ethenyl; and R2 is alkyl, alkoxy, or halogen.

公开(公告)号：US09975849B1

公开(公告)日：2018-05-22

申请号：US15798877

申请日：2017-10-31

申请人： Xiaolin Xie ,  Dezhu Zhang ,  Chengyuan Liang ,  Lei Tian ,  Shunjun Ding ,  Xingke Ju

发明人： Xiaolin Xie ,  Dezhu Zhang ,  Chengyuan Liang ,  Lei Tian ,  Shunjun Ding ,  Xingke Ju

IPC分类号： C07C279/14 ,  C07C277/08

CPC分类号： C07C279/14 ,  C07B2200/07 ,  C07B2200/13 ,  C07C277/08

摘要： A compound with antitumor activities is represented by formula I: A method of preparing the compound of formula I is also disclosed.

公开(公告)号：US10343988B1

公开(公告)日：2019-07-09

申请号：US16359988

申请日：2019-03-20

申请人： Chengyuan Liang ,  Lei Tian ,  Danni Tian ,  Yuzhi Liu ,  Xingke Ju ,  Nan Hui ,  Mi Wu ,  Juan Li ,  Han Li ,  Bin Tian ,  Qianqian Zhao

发明人： Chengyuan Liang ,  Lei Tian ,  Danni Tian ,  Yuzhi Liu ,  Xingke Ju ,  Nan Hui ,  Mi Wu ,  Juan Li ,  Han Li ,  Bin Tian ,  Qianqian Zhao

IPC分类号： C07C323/56 ,  C07C319/20 ,  C09K15/14

摘要： A compound having the following formula I: is disclosed. A method of preparing the compound of formula I is also disclosed.

公开(公告)号：US10815348B2

公开(公告)日：2020-10-27

申请号：US16027193

申请日：2018-07-03

申请人： Xuechuan Wang ,  Ouyang Yue ,  Xinhua Liu ,  Taotao Qiang ,  Longfang Ren ,  Lei Tian ,  Minyi Jia ,  Xingke Ju ,  Chengyuan Liang

发明人： Xuechuan Wang ,  Ouyang Yue ,  Xinhua Liu ,  Taotao Qiang ,  Longfang Ren ,  Lei Tian ,  Minyi Jia ,  Xingke Ju ,  Chengyuan Liang

IPC分类号： C09H3/00 ,  C08J5/18 ,  B65D65/46 ,  C08L89/06 ,  G01N33/569

摘要： A method of preparing an aesculin sturgeon skin gelatin with antioxidant activity and Enterococcus faecalis detection ability includes: 1) mixing a sturgeon skin gelatin and distilled water in a ratio of 1:15-1:25 (w/v) at 50-70° C. and filtering to obtain a sturgeon skin gelatin solution; 2) adding aesculin and a glycerin solution to the sturgeon skin gelatin solution, stirring the resulted sturgeon skin gelatin solution at 30-50° C. for 30 minutes, and filtering; and 3) removing air bubbles from the sturgeon skin gelatin solution of step 2) under reduced pressure, placing the sturgeon skin gelatin solution on an acrylic glass, and drying the sturgeon skin gelatin solution at in a vented oven 25° C. and 45-55% relative humidity for 24 hours to obtain the aesculin sturgeon skin gelatin film.

公开(公告)号：US10729675B2

公开(公告)日：2020-08-04

申请号：US16270567

申请日：2019-02-07

申请人： Chengyuan Liang ,  Xingke Ju ,  Shunjun Ding ,  Lei Tian ,  Yuzhi Liu ,  Xiaolin Xie ,  Dezhu Zhang ,  Wenbo Yao ,  Dan Yang

发明人： Chengyuan Liang ,  Xingke Ju ,  Shunjun Ding ,  Lei Tian ,  Yuzhi Liu ,  Xiaolin Xie ,  Dezhu Zhang ,  Wenbo Yao ,  Dan Yang

IPC分类号： A61K31/404 ,  A61P35/00 ,  G01N33/50

摘要： A gossypol isatin Schiff base compound with antitumor activities represented by formula I: R1 and R2 are independently hydrogen, alkyl, cycloalkyl, alkoxy, nitro, halogen, unsubstituted or substituted phenyl, or unsubstituted or substituted benzyl. A method of preparing the compound of formula I is also disclosed.

公开(公告)号：US10059698B2

公开(公告)日：2018-08-28

申请号：US15719924

申请日：2017-09-29

申请人： Chengyuan Liang ,  Minyi Jia ,  Yuecheng Lyu ,  Xingke Ju ,  Lei Tian

发明人： Chengyuan Liang ,  Minyi Jia ,  Yuecheng Lyu ,  Xingke Ju ,  Lei Tian

IPC分类号： C07D405/12

CPC分类号： C07D405/12

摘要： A hesperetin aza-cinnamic acid derivative has the following formula (I): R1 is H or alkyl, and R2 and R2 are independently H, alkyl, hydroxy, halogen, nitro, or alkoxy.

公开(公告)号：US10072020B1

公开(公告)日：2018-09-11

申请号：US15957867

申请日：2018-04-19

申请人： Chengyuan Liang ,  Danni Tian ,  Shunjun Ding

发明人： Chengyuan Liang ,  Danni Tian ,  Shunjun Ding

IPC分类号： C07D491/107

CPC分类号： C07D491/107

摘要： An isatin spiro compound having the following formula (I): R1 is halogen or C1-3 alkyl; R2 is C1-3 alkyl or benzyl; and R3 and R3′ are independently H, C1-3 alkyl or phenyl.