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    Serum or plasma microRNA as biomarkers for non-small cell lung cancer
    1.
    发明授权
    Serum or plasma microRNA as biomarkers for non-small cell lung cancer 有权
    血清或血浆microRNA作为非小细胞肺癌的生物标志物

    公开(公告)号：US09388470B2

    公开(公告)日：2016-07-12

    申请号：US12996967

    申请日：2009-12-14

    申请人： Chenyu Zhang ,  Ke Zeng ,  Junfeng Zhang ,  Yi Ba ,  Xi Chen ,  Haijin Li

    发明人： Chenyu Zhang ,  Ke Zeng ,  Junfeng Zhang ,  Yi Ba ,  Xi Chen ,  Haijin Li

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178

    摘要： The present invention provides non-small cell lung cancer markers and the use thereof in diagnosing and monitoring diseases in vitro. The non-small cell lung cancer markers include at least one of the 26 selected detectable mature microRNAs existing stably in human serum or plasma. The invention also provides probe combinations, a kit and biochip for detecting the non-small cell lung cancer markers. The invention further provides a method for detecting the said lung cancer markers. The method in the present invention enables extensive detection spectrum, high sensitivity, low cost, convenient sample taking and preservation. The method can be applied in the general survey of disease, solves problems of the low specificity and sensitivity encountered with previous single markers, and increases significantly the clinical detection rate of diseases; it forms an effective means for diagnosing diseases at an early stage.

    摘要翻译： 本发明提供非小细胞肺癌标志物及其在体外诊断和监测疾病中的应用。 非小细胞肺癌标志物包括稳定存在于人血清或血浆中的26种选择的可检测的成熟微RNA中的至少一种。 本发明还提供探针组合，用于检测非小细胞肺癌标志物的试剂盒和生物芯片。 本发明还提供了一种用于检测所述肺癌标志物的方法。 本发明的方法能够广泛的检测光谱，高灵敏度，低成本，便于取样和保存。 该方法可应用于疾病一般调查，解决了以前单个标记物遇到的低特异性和敏感性问题，大大提高了疾病的临床检出率; 它是早期诊断疾病的有效手段。

    SERUM/PLASMA MICRONAS AND USES THEREOF
    2.
    发明申请
    SERUM/PLASMA MICRONAS AND USES THEREOF 审中-公开

    公开(公告)号：US20100173288A1

    公开(公告)日：2010-07-08

    申请号：US12302196

    申请日：2007-12-06

    申请人： Chenyu Zhang ,  Junfeng Zhang ,  Xi Chen ,  Yi Ba ,  Jiangning Chen ,  Jin Wang ,  Ke Zeng ,  Hongjie Zhang

    发明人： Chenyu Zhang ,  Junfeng Zhang ,  Xi Chen ,  Yi Ba ,  Jiangning Chen ,  Jin Wang ,  Ke Zeng ,  Hongjie Zhang

    IPC分类号： C12Q1/68 ,  C12M1/34

    CPC分类号： C12Q1/6886 ,  C12Q1/6809 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Q2600/178 ,  C12Q2525/207

    摘要： This invention provides a combination of microRNAs for evaluating the physiological and/or pathological condition of a subject, wherein the combination comprises all detectable microRNAs stably existing in the serum/plasma of a subject; and a method for evaluating the physiological and/or pathological condition of a subject, wherein the method includes determining all detectable microRNAs stably existing in the serum/plasma of a subject; and a kit for evaluating the physiological and/or pathological condition of a subject, wherein the kit contains the tools for determining all detectable microRNAs that stably existing in the serum/plasma of a subject; and a biochip for evaluating the physiological and/or pathological condition of a subject, wherein the biochip contains the components for determining all detectable microRNAs stably existing in the serum/plasma of a subject. The aforementioned combination, method, kit and biochip can be used for diagnosis as well as differentially diagnosis of diseases including various tumors; various acute/chronic infectious diseases, e.g. viral diseases such as viral influenza, viral hepatitis, AIDS, SARS, bacterial diseases such as tuberculosis, bacterial pneumonia, and other acute/chronic infectious diseases caused by various pathogenic microorganisms; other acute/chronic diseases such as diseases of respiratory system, diseases of immune system, diseases of blood and hematopoietic system, diseases of circulatory system such as cardio-cerebrovascular diseases, metabolic diseases of endocrine system, diseases of digestive system, diseases of nervous system, diseases of urinary system, diseases of reproductive system and diseases of locomotor system, prediction of complications occurrence and malignant diseases relapse, evaluation of therapeutic effects, screening of pharmaceutical active ingredients, assessment of drug efficacy as well as forensic authentication and prohibited drug inspection and the like, possessing a number of advantages such as extensive detection spectrum, high sensitivity, low cost, convenience for sampling, ease for sample preservation, etc. The said method can be widely used in work related to general survey of diseases and so on, improve the low-specificity and low-sensitivity caused by individual differences which single markers are difficult to overcome, significantly increasing the clinical detection rate of diseases, all of which make it become an effective means for diagnosing diseases in an early phase.

    SERUM OR PLASMA MICRORNA AS BIOMARKERS FOR NON-SMALL CELL LUNG CANCER
    5.
    发明申请
    SERUM OR PLASMA MICRORNA AS BIOMARKERS FOR NON-SMALL CELL LUNG CANCER 有权
    血清或血浆MICRORNA作为非小细胞肺癌的生物标志物

    公开(公告)号：US20110117565A1

    公开(公告)日：2011-05-19

    申请号：US12996967

    申请日：2009-12-14

    申请人： Chenyu Zhang ,  Ke Zeng ,  Junfeng Zhang ,  Yi Ba ,  Xi Chen ,  Haijin Li

    发明人： Chenyu Zhang ,  Ke Zeng ,  Junfeng Zhang ,  Yi Ba ,  Xi Chen ,  Haijin Li

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178

    摘要： The present invention provides non-small cell lung cancer markers and the use thereof. The non-small cell lung cancer markers in the present invention include at least one of the 26 selected detectable mature microRNAs existing stably in human serum or plasma. The invention also provides a probe combination, kit and biochip for detecting the non-small cell lung cancer markers. The invention further provides a method for detecting microRNAs in the serum of lung cancer patients. By detecting the variations of microRNAs in the serum of lung cancer patients, the disease can be diagnosed in vitro; the progression course of the disease can be predicted; the occurrence of complications, the rate of relapse and the prognosis of the disease can be monitored; the drug efficacy and therapeutic effects can be analyzed. The method in the present invention enables extensive detection spectrum, high sensitivity, low cost, convenient sample taking and preservation. The method can be applied in the general survey of disease, solves problems of the low specificity and sensitivity encountered with previous single markers, and increases significantly the clinical detection rate of diseases, all of which make it an effective means for diagnosing diseases at an early stage.

    摘要翻译： 本发明提供非小细胞肺癌标志物及其用途。 本发明中的非小细胞肺癌标志物包括稳定存在于人血清或血浆中的26种选择的可检测的成熟微RNA中的至少一种。 本发明还提供了用于检测非小细胞肺癌标志物的探针组合，试剂盒和生物芯片。 本发明还提供了一种检测肺癌患者血清中微小RNA的方法。 通过检测肺癌患者血清中microRNAs的变化，可以在体外诊断该疾病; 可以预测疾病的进展过程; 可以监测并发症的发生，复发率和预后; 可以分析药物的疗效和治疗效果。 本发明的方法能够广泛的检测光谱，高灵敏度，低成本，便于取样和保存。 该方法可应用于疾病综合调查，解决了以前单个标记物所遇到的低特异性和敏感性问题，并大大增加了疾病的临床检出率，这些都成为早期诊断疾病的有效手段 阶段。

    INPUT METHOD EDITOR APPLICATION PLATFORM
    8.
    发明申请
    INPUT METHOD EDITOR APPLICATION PLATFORM 有权
    输入法编辑器应用平台

    公开(公告)号：US20130346872A1

    公开(公告)日：2013-12-26

    申请号：US13586267

    申请日：2012-08-15

    申请人： Matthew Robert Scott ,  Huihua Hou ,  Xi Chen ,  Weipeng Liu ,  Rongfeng Lai ,  Xi Chen ,  Yonghong Shi

    发明人： Matthew Robert Scott ,  Huihua Hou ,  Xi Chen ,  Weipeng Liu ,  Rongfeng Lai ,  Xi Chen ,  Yonghong Shi

    IPC分类号： G06F3/048 ,  G06F15/16

    CPC分类号： G06F17/276 ,  G06F3/0237 ,  G06F3/04842 ,  G06F17/24 ,  G06F17/273 ,  G06F17/2735 ,  G06F17/30241 ,  G06F17/30477 ,  G06F17/30554 ,  G06F17/3056 ,  G06F17/3064 ,  G06F17/3087 ,  G06Q10/10 ,  G06Q50/01 ,  H04L51/10 ,  H04L51/32

    摘要： An input method editor (IME) provides a distributed platform architecture that enables associating multiple applications with the IME to provide extended functionalities. The presentations of the applications, such as skins, may be different from each other and that of the IME. The applications may be represented in a manifest file that is human-readable and editable. The IME collects multiple parameters relating to a user input into a host application including a query input by the user and a scenario of the host application, and selects one or more applications to provide candidates based on a score or ranking of the applications under the collected multiple parameters. Machine-learning may be used to improve the score or ranking. The candidates may include text candidates, rich candidates, and informative candidates.

    摘要翻译： 输入法编辑器（IME）提供了一种分布式平台架构，可将多个应用程序与IME相关联，以提供扩展功能。 应用程序的介绍（如皮肤）可能会彼此不同，也可能与IME的不同。 应用程序可以在人类可读和可编辑的清单文件中表示。 IME收集与主机应用中的用户输入有关的多个参数，包括用户输入的查询和主机应用的场景，并且根据所收集的应用程序的得分或排名选择一个或多个应用程序来提供候选者 多个参数。 机器学习可用于提高得分或排名。 候选人可以包括文本候选人，丰富的候选人和资料丰富的候选人。

    Semantic Lexicon-Based Input Method Editor
    9.
    发明申请
    Semantic Lexicon-Based Input Method Editor 有权
    基于语义词法的输入法编辑器

    公开(公告)号：US20150121290A1

    公开(公告)日：2015-04-30

    申请号：US13635274

    申请日：2012-06-29

    申请人： Chi-Ho Li ,  Weijiang Xu ,  Matthew Robert Scott ,  Weipeng Liu ,  Xi Chen ,  Xi Chen

    发明人： Chi-Ho Li ,  Weijiang Xu ,  Matthew Robert Scott ,  Weipeng Liu ,  Xi Chen ,  Xi Chen

    IPC分类号： G06F17/30 ,  G06F3/0482

    CPC分类号： G06F17/30675 ,  G06F3/0482 ,  G06F17/2785

    摘要： Some implementations provide techniques and arrangements for semantic lexicon based processing, such as in an input method editor. In some instances, a semantic label may be received that is to be defined for a semantic lexicon and at least a first term may be identified as a positive or negative example of the semantic label. In response, some examples may label at least a second term in the semantic lexicon with the semantic label based at least in part on the identification of the first term as a positive or negative example of the semantic label.

    摘要翻译： 一些实现提供了基于语义词典的处理的技术和布置，例如在输入法编辑器中。 在一些情况下，可以接收将为语义词典定义的语义标签，并且至少第一项可以被识别为语义标签的正或负例子。 作为响应，一些示例可以至少部分地基于第一术语的标识作为语义标签的正或负例示，将具有语义标签的语义词典中的至少第二项标记为语义标签。

    Personal language model for input method editor
    10.
    发明授权
    Personal language model for input method editor 有权

    公开(公告)号：US09824085B2

    公开(公告)日：2017-11-21

    申请号：US14423914

    申请日：2012-08-31

    申请人： Mu Li ,  Xi Chen

    发明人： Mu Li ,  Xi Chen

    IPC分类号： G06F17/28 ,  G06F17/22 ,  G06F17/27

    CPC分类号： G06F17/2863 ,  G06F17/2223 ,  G06F17/276

    摘要： Some examples include generating a personal language model based on linguistic characteristics of one or more files stored at one or more locations in a file system. Further, some implementations include predicting and presenting a non-Latin character string based at least in part on the personal language model, such as in response to receiving a Latin character string via an input method editor interface.